메뉴 건너뛰기




Volumn 316, Issue 4, 2010, Pages 627-637

Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway

Author keywords

Fused; Gli proteins; Phosphorylation; Signaling; Sonic Hedgehog (Shh); unc 51 like kinase 3 (ULK3)

Indexed keywords

PROTEIN SERINE THREONINE KINASE; SONIC HEDGEHOG PROTEIN; UNC 51 LIKE KINASE 3; UNCLASSIFIED DRUG; GLI PROTEIN; MESSENGER RNA; ONCOPROTEIN; SHH PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; ULK3 PROTEIN, HUMAN;

EID: 77449084158     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2009.10.018     Document Type: Article
Times cited : (67)

References (51)
  • 2
    • 0002452569 scopus 로고    scopus 로고
    • Developmental roles and clinical significance of hedgehog signaling
    • [2] McMahon, A.P., Ingham, P.W., Tabin, C.J., Developmental roles and clinical significance of hedgehog signaling. Curr. Top. Dev. Biol. 53 (2003), 1–114.
    • (2003) Curr. Top. Dev. Biol. , vol.53 , pp. 1-114
    • McMahon, A.P.1    Ingham, P.W.2    Tabin, C.J.3
  • 3
    • 33645734474 scopus 로고    scopus 로고
    • Hedgehog signalling: how to get from Smo to Ci and Gli
    • [3] Osterlund, T., Kogerman, P., Hedgehog signalling: how to get from Smo to Ci and Gli. Trends Cell Biol. 16 (2006), 176–180.
    • (2006) Trends Cell Biol. , vol.16 , pp. 176-180
    • Osterlund, T.1    Kogerman, P.2
  • 4
    • 31744436876 scopus 로고    scopus 로고
    • Divergence of hedgehog signal transduction mechanism between Drosophila and mammals
    • [4] Varjosalo, M., Li, S.P., Taipale, J., Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev. Cell 10 (2006), 177–186.
    • (2006) Dev. Cell , vol.10 , pp. 177-186
    • Varjosalo, M.1    Li, S.P.2    Taipale, J.3
  • 5
    • 23844552405 scopus 로고    scopus 로고
    • Cooperative requirement of the Gli proteins in neurogenesis
    • [5] Nguyen, V., Chokas, A.L., Stecca, B., Ruiz i Altaba, A., Cooperative requirement of the Gli proteins in neurogenesis. Development 132 (2005), 3267–3279.
    • (2005) Development , vol.132 , pp. 3267-3279
    • Nguyen, V.1    Chokas, A.L.2    Stecca, B.3    Ruiz i Altaba, A.4
  • 6
    • 2942738996 scopus 로고    scopus 로고
    • The Hedgehog response network: sensors, switches, and routers
    • [6] Lum, L., Beachy, P.A., The Hedgehog response network: sensors, switches, and routers. Science 304 (2004), 1755–1759.
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 9
    • 31544461492 scopus 로고    scopus 로고
    • Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling
    • [9] Riobo, N.A., Haines, G.M., Emerson, C.P. Jr, Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling. Cancer Res. 66 (2006), 839–845.
    • (2006) Cancer Res. , vol.66 , pp. 839-845
    • Riobo, N.A.1    Haines, G.M.2    Emerson, C.P.3
  • 10
    • 33645220566 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
    • [10] Riobo, N.A., Lu, K., Ai, X., Haines, G.M., Emerson, C.P. Jr, Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc. Natl. Acad. Sci. U. S. A. 103 (2006), 4505–4510.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 4505-4510
    • Riobo, N.A.1    Lu, K.2    Ai, X.3    Haines, G.M.4    Emerson, C.P.5
  • 12
  • 13
    • 0037041470 scopus 로고    scopus 로고
    • Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
    • [13] Jia, J., Amanai, K., Wang, G., Tang, J., Wang, B., Jiang, J., Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 416 (2002), 548–552.
    • (2002) Nature , vol.416 , pp. 548-552
    • Jia, J.1    Amanai, K.2    Wang, G.3    Tang, J.4    Wang, B.5    Jiang, J.6
  • 14
    • 0033846864 scopus 로고    scopus 로고
    • Transcriptional activity of GLI1 is negatively regulated by protein kinase A
    • [14] Kaesler, S., Luscher, B., Ruther, U., Transcriptional activity of GLI1 is negatively regulated by protein kinase A. Biol. Chem. 381 (2000), 545–551.
    • (2000) Biol. Chem. , vol.381 , pp. 545-551
    • Kaesler, S.1    Luscher, B.2    Ruther, U.3
  • 16
    • 0027383291 scopus 로고
    • Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a suppressor of fused background reveals interaction with costal-2
    • [16] Preat, T., Therond, P., Limbourg-Bouchon, B., Pham, A., Tricoire, H., Busson, D., Lamour-Isnard, C., Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a suppressor of fused background reveals interaction with costal-2. Genetics 135 (1993), 1047–1062.
    • (1993) Genetics , vol.135 , pp. 1047-1062
    • Preat, T.1    Therond, P.2    Limbourg-Bouchon, B.3    Pham, A.4    Tricoire, H.5    Busson, D.6    Lamour-Isnard, C.7
  • 18
    • 0036173545 scopus 로고    scopus 로고
    • The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling
    • [18] Ascano, M. Jr., Nybakken, K.E., Sosinski, J., Stegman, M.A., Robbins, D.J., The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling. Mol. Cell Biol. 22 (2002), 1555–1566.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 1555-1566
    • Ascano, M.1    Nybakken, K.E.2    Sosinski, J.3    Stegman, M.A.4    Robbins, D.J.5
  • 19
    • 33846924332 scopus 로고    scopus 로고
    • The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway
    • [19] Malpel, S., Claret, S., Sanial, M., Brigui, A., Piolot, T., Daviet, L., Martin-Lanneree, S., Plessis, A., The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway. Dev. Biol. 303 (2007), 121–133.
    • (2007) Dev. Biol. , vol.303 , pp. 121-133
    • Malpel, S.1    Claret, S.2    Sanial, M.3    Brigui, A.4    Piolot, T.5    Daviet, L.6    Martin-Lanneree, S.7    Plessis, A.8
  • 20
    • 0032492995 scopus 로고    scopus 로고
    • Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway
    • [20] Monnier, V., Dussillol, F., Alves, G., Lamour-Isnard, C., Plessis, A., Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway. Curr. Biol. 8 (1998), 583–586.
    • (1998) Curr. Biol. , vol.8 , pp. 583-586
    • Monnier, V.1    Dussillol, F.2    Alves, G.3    Lamour-Isnard, C.4    Plessis, A.5
  • 21
    • 34547608994 scopus 로고    scopus 로고
    • Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused
    • [21] Claret, S., Sanial, M., Plessis, A., Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused. Curr. Biol. 17 (2007), 1326–1333.
    • (2007) Curr. Biol. , vol.17 , pp. 1326-1333
    • Claret, S.1    Sanial, M.2    Plessis, A.3
  • 22
    • 10744233219 scopus 로고    scopus 로고
    • Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
    • [22] Lum, L., Zhang, C., Oh, S., Mann, R.K., von Kessler, D.P., Taipale, J., Weis-Garcia, F., Gong, R., Wang, B., Beachy, P.A., Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol. Cell 12 (2003), 1261–1274.
    • (2003) Mol. Cell , vol.12 , pp. 1261-1274
    • Lum, L.1    Zhang, C.2    Oh, S.3    Mann, R.K.4    von Kessler, D.P.5    Taipale, J.6    Weis-Garcia, F.7    Gong, R.8    Wang, B.9    Beachy, P.A.10
  • 23
    • 0141728540 scopus 로고    scopus 로고
    • Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
    • [23] Ruel, L., Rodriguez, R., Gallet, A., Lavenant-Staccini, L., Therond, P.P., Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Nat. Cell Biol 5 (2003), 907–913.
    • (2003) Nat. Cell Biol , vol.5 , pp. 907-913
    • Ruel, L.1    Rodriguez, R.2    Gallet, A.3    Lavenant-Staccini, L.4    Therond, P.P.5
  • 24
    • 0037025382 scopus 로고    scopus 로고
    • Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused
    • [24] Nybakken, K.E., Turck, C.W., Robbins, D.J., Bishop, J.M., Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused. J. Biol. Chem. 277 (2002), 24638–24647.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24638-24647
    • Nybakken, K.E.1    Turck, C.W.2    Robbins, D.J.3    Bishop, J.M.4
  • 28
    • 57749205263 scopus 로고    scopus 로고
    • A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation
    • [28] Maloveryan, A., Finta, C., Osterlund, T., Kogerman, P., A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. J. Cell Commun. Signal. 1 (2007), 165–173.
    • (2007) J. Cell Commun. Signal. , vol.1 , pp. 165-173
    • Maloveryan, A.1    Finta, C.2    Osterlund, T.3    Kogerman, P.4
  • 29
    • 18644383201 scopus 로고    scopus 로고
    • Expression of the human FUSED protein in Drosophila
    • [29] Daoud, F., Blanchet-Tournier, M.F., Expression of the human FUSED protein in Drosophila. Dev. Genes Evol. 215 (2005), 230–237.
    • (2005) Dev. Genes Evol. , vol.215 , pp. 230-237
    • Daoud, F.1    Blanchet-Tournier, M.F.2
  • 30
    • 23344453462 scopus 로고    scopus 로고
    • Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development
    • [30] Chen, M.H., Gao, N., Kawakami, T., Chuang, P.T., Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Mol. Cell. Biol. 25 (2005), 7042–7053.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 7042-7053
    • Chen, M.H.1    Gao, N.2    Kawakami, T.3    Chuang, P.T.4
  • 32
    • 31744451535 scopus 로고    scopus 로고
    • Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
    • [32] Svard, J., Heby-Henricson, K., Persson-Lek, M., Rozell, B., Lauth, M., Bergstrom, A., Ericson, J., Toftgard, R., Teglund, S., Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev. Cell 10 (2006), 187–197.
    • (2006) Dev. Cell , vol.10 , pp. 187-197
    • Svard, J.1    Heby-Henricson, K.2    Persson-Lek, M.3    Rozell, B.4    Lauth, M.5    Bergstrom, A.6    Ericson, J.7    Toftgard, R.8    Teglund, S.9
  • 33
    • 0038813753 scopus 로고    scopus 로고
    • Characterization of the physical interaction of Gli proteins with SUFU proteins
    • [33] Dunaeva, M., Michelson, P., Kogerman, P., Toftgard, R., Characterization of the physical interaction of Gli proteins with SUFU proteins. J. Biol. Chem. 278 (2003), 5116–5122.
    • (2003) J. Biol. Chem. , vol.278 , pp. 5116-5122
    • Dunaeva, M.1    Michelson, P.2    Kogerman, P.3    Toftgard, R.4
  • 35
    • 33645763522 scopus 로고    scopus 로고
    • A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues
    • [35] Speek, M., Njunkova, O., Pata, I., Valdre, E., Kogerman, P., A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues. BMC Mol. Biol., 7, 2006, 13.
    • (2006) BMC Mol. Biol. , vol.7 , pp. 13
    • Speek, M.1    Njunkova, O.2    Pata, I.3    Valdre, E.4    Kogerman, P.5
  • 37
    • 0029004233 scopus 로고
    • Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
    • [37] Roelink, H., Porter, J.A., Chiang, C., Tanabe, Y., Chang, D.T., Beachy, P.A., Jessell, T.M., Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 81 (1995), 445–455.
    • (1995) Cell , vol.81 , pp. 445-455
    • Roelink, H.1    Porter, J.A.2    Chiang, C.3    Tanabe, Y.4    Chang, D.T.5    Beachy, P.A.6    Jessell, T.M.7
  • 39
    • 33644849523 scopus 로고    scopus 로고
    • Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal
    • [39] Sheng, T., Chi, S., Zhang, X., Xie, J., Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal. J. Biol. Chem. 281 (2006), 9–12.
    • (2006) J. Biol. Chem. , vol.281 , pp. 9-12
    • Sheng, T.1    Chi, S.2    Zhang, X.3    Xie, J.4
  • 40
    • 0034651750 scopus 로고    scopus 로고
    • Multiple probing of an immunoblot membrane using a non-block technique: advantages in speed and sensitivity
    • [40] Sadra, A., Cinek, T., Imboden, J.B., Multiple probing of an immunoblot membrane using a non-block technique: advantages in speed and sensitivity. Anal. Biochem. 278 (2000), 235–237.
    • (2000) Anal. Biochem. , vol.278 , pp. 235-237
    • Sadra, A.1    Cinek, T.2    Imboden, J.B.3
  • 42
    • 0033377776 scopus 로고    scopus 로고
    • A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons
    • [42] Tomoda, T., Bhatt, R.S., Kuroyanagi, H., Shirasawa, T., Hatten, M.E., A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons. Neuron 24 (1999), 833–846.
    • (1999) Neuron , vol.24 , pp. 833-846
    • Tomoda, T.1    Bhatt, R.S.2    Kuroyanagi, H.3    Shirasawa, T.4    Hatten, M.E.5
  • 43
    • 33748951151 scopus 로고    scopus 로고
    • Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
    • [43] Fuccillo, M., Joyner, A.L., Fishell, G., Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development. Nat. Rev. Neurosci. 7 (2006), 772–783.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 772-783
    • Fuccillo, M.1    Joyner, A.L.2    Fishell, G.3
  • 44
    • 41549118422 scopus 로고    scopus 로고
    • The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer
    • [44] Omenetti, A., Diehl, A.M., The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer. Am. J. Physiol. Gastrointest. Liver Physiol. 294 (2008), G595–G598.
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.294 , pp. G595-G598
    • Omenetti, A.1    Diehl, A.M.2
  • 45
    • 0037218819 scopus 로고    scopus 로고
    • Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
    • [45] Lai, K., Kaspar, B.K., Gage, F.H., Schaffer, D.V., Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat. Neurosci. 6 (2003), 21–27.
    • (2003) Nat. Neurosci. , vol.6 , pp. 21-27
    • Lai, K.1    Kaspar, B.K.2    Gage, F.H.3    Schaffer, D.V.4
  • 46
    • 0032765804 scopus 로고    scopus 로고
    • A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve
    • [46] Wallace, V.A., Raff, M.C., A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve. Development 126 (1999), 2901–2909.
    • (1999) Development , vol.126 , pp. 2901-2909
    • Wallace, V.A.1    Raff, M.C.2
  • 48
    • 0034681266 scopus 로고    scopus 로고
    • Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    • [48] Wang, B., Fallon, J.F., Beachy, P.A., Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100 (2000), 423–434.
    • (2000) Cell , vol.100 , pp. 423-434
    • Wang, B.1    Fallon, J.F.2    Beachy, P.A.3
  • 49
    • 33646270662 scopus 로고    scopus 로고
    • Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
    • [49] Pan, Y., Bai, C.B., Joyner, A.L., Wang, B., Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 26 (2006), 3365–3377.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 3365-3377
    • Pan, Y.1    Bai, C.B.2    Joyner, A.L.3    Wang, B.4
  • 50
    • 58549117286 scopus 로고    scopus 로고
    • Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development
    • [50] Pan, Y., Wang, C., Wang, B., Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev. Biol. 326 (2009), 177–189.
    • (2009) Dev. Biol. , vol.326 , pp. 177-189
    • Pan, Y.1    Wang, C.2    Wang, B.3
  • 51
    • 30444437000 scopus 로고    scopus 로고
    • Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing
    • [51] Wang, B., Li, Y., Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proc. Natl. Acad. Sci. U. S. A. 103 (2006), 33–38.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 33-38
    • Wang, B.1    Li, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.