Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

Genes and Development

Volumn 17, Issue 21, 2003, Pages 2709-2720

  Jia, Jianhang ^a   Tong, Chao ^a   Jiang, Jin ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cos2; Development; Fu; Hh; Signaling; Smo

Indexed keywords

MEMBRANE PROTEIN; PROTEIN SMO; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL GROWTH; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TRANSGENE; WESTERN BLOTTING;

ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; KINESIN; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE DELETION; SIGNAL TRANSDUCTION;

ANIMALIA; ERINACEIDAE; INVERTEBRATA; VERTEBRATA;

EID: 0242361620     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1136603     Document Type: Article

References (52)

1. Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M., and Hooper, J.E. 1996. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal. Cell 86: 221-232.
2. Alexandre, C., Jacinto, A., and Ingham, P.W. 1996. Transcriptional activation of Hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of the zinc finger DNA-binding proteins. Genes & Dev. 10: 2003-2013.
3. Amanai, K. and Jiang, J. 2001. Distinct roles of Central missing and Dispatched in sending the Hedgehog signal. Development 128: 5119-5127.
4. Ascano Jr., M., Nybakken, K.E., Sosinski, J., Stegman, M.A., and Robbins, D.J. 2002. The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling. Mol. Cell. Biol. 22: 1555-1566.
5. Aza-Blanc, P., Ramirez-Weber, F., Laget, M., Schwartz, C., and Komberg, T. 1997. Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89: 1043-1053.
6. Aza-Blanc, P., Lin, H.Y., Ruiz i Altaba, A., and Kornberg, T.B. 2000. Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development 127: 4293-4301.
7. Basler, K. and Struhl, G. 1994. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368: 208-214.
8. Brand, A.H. and Perrimon, N. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
9. Chen, Y. and Struhl, G. 1996. Dual roles for patched in sequestering and transducing Hedgehog. Cell 87: 553-563.
10. -. 1998. In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Development 125: 4943-4948.
11. Chen, C.H., von Kessler, D.P., Park, W., Wang, B., Ma, Y., and Beachy, P.A. 1999. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell 98: 305-316.
12. Chen, Y., Cardinaux, J.R., Goodman, R.H., and Smolik, S.M. 1999. Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling. Development 126: 3607-3616.
13. Cheng, S.Y. and Bishop, J.M. 2002. Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proc. Natl. Acad. Sci. 99: 5442-5447.
14. Denef, N., Neubuser, D., Perez, L., and Cohen, S.M. 2000. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102: 521-531.
15. Ingham, P.W. and McMahon, A.P. 2001. Hedgehog signaling in animal development: Paradigms and principles. Genes & Dev. 15: 3059-3087.
16. Jia, J., Amanai, K., Wang, G., Tang, J., Wang, B., and Jiang, J. 2002. Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 416: 548-552.
17. Jiang, J. 2002. Degrading Ci: Who is Cul-pable? Genes & Dev. 16: 2315-2321.
18. Jiang, J. and Struhl, G. 1995. Protein kinase A and Hedgehog signalling in Drosophila limb development. Cell 80: 563-572.
19. -. 1998. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 391: 493-496.
20. Lecuit, T., Brook, W.J., Ng, M., Callega, M., Sun, H., and Cohen, S.M. 1996. Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381: 387-393.
21. Mao, J., Wang, J., Liu, B., Pan, W., Far III, G.H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. 2001. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol. Cell 7: 801-809.
22. Methot, N. and Basler, K. 1999. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96: 819-831.
23. -. 2000. Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development 127: 4001-4010.
24. Monnier, V., Ho, K.S., Sanial, M., Scott, M.P., and Plessis, A. 2002. Hedgehog signal transduction proteins: Contacts of the Fused kinase and Ci transcription factor with the Kinesin-related protein Costal2. BMC Dev. Biol. 2: 4.
25. Motzny, C.K. and Holmgren, R. 1995. The Drosophila cubitus interruptus protein and its role in the Mngless and hedgehog signal transduction pathways. Mech. Dev. 52: 137-150.
26. Murone, M., Rosenthal, A., and de Sauvage, F.J. 1999. Sonic hedgehog signaling by the patched-smoothened receptor complex. Curr. Biol. 9: 76-84.
27. Nellen, D., Burke, R., Struhl, G., and Basler, K. 1996. Direct and long-range action of a DPP morphogen gradient. Cell 85: 357-368.
28. Ohlmeyer, J.T. and Kalderon, D. 1997. Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes & Dev. 11: 2250-2258.
29. -. 1998. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 396: 749-753.
30. Pignoni, F., Hu, B., Zavitz, K.H., Xiao, J., Garrity, P.A., and Zipursky, S.L. 1997. The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell 91: 881-891; erratum. 1998. Cell 92: 585.
31. Pignoni, F., Hu, B., Zavitz, K.H., Xiao, J., Garrity, P.A., and Zipursky, S.L. 1997. The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell 91: 881-891; erratum. 1998. Cell 92: 585.
32. Preat, T. 1992. Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster. Genetics 132: 725-736.
33. Price, M.A. and Kalderon, D. 1999. Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. Development 126: 4331-4339.
34. -. 2002. Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by glycogen synthase kinase 3 and casein kinase 1. Cell 108: 823-835.
35. Robbins, D.J., Nybakken, K.E., Kobayashi, R., Sisson, J.C., Bishop, J.M., and Therond, P.P. 1997. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell 90: 225-234.
36. Schlessinger, J. 2000. Cell signaling by receptor tyrosine kinases. Cell 103: 211-225.
37. Sisson, J.C., Ho, K.S., Suyama, K., and Scott, M.P. 1997. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 90: 235-245.
38. Stegman, M.A., Vallance, J.E., Elangovan, G., Sosinski, J., Cheng, Y., and Robbins, D.J. 2000. Identification of a tetrameric hedgehog signaling complex. J. Biol. Chem. 275: 21809-21812.
39. Stone, D.M., Hynes, M., Armanini, M., Swanson, T.A., Gu, Q., Johnson, R.L., Scott, M.P., Pennica, D., Goddard, A., Phillips, H., et al. 1996. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384: 129-134.
40. Strigini, M. and Cohen, S.M. 1997. A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124: 4697-4705.
41. Struhl, G. and Adachi, A. 1998. Nuclear access and action of notch in vivo. Cell 93: 649-660.
42. Tabata, T. and Komberg, T.B. 1994. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76: 89-102.
43. Taipale, J. and Beachy, P.A. 2001. The Hedgehog and Wnt signalling pathways in cancer. Nature 411: 349-354.
44. van-den-Heuval, M. and Ingham, P.W. 1996. smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 382: 547-551.
45. Vegh, M. and Basler, K. 2003. A genetic screen for hedgehog targets involved in the maintenance of the Drosophila anteroposterior compartment boundary. Genetics 163: 1427-1438.
46. Villavicencio, E.H., Walterhouse, D.O., and Iannaccone, P.M. 2000. The Sonic hedgehog-Patched-gli pathway in human development and disease. Am. J. Hum. Genet. 67: 1047-1054.
47. Wang, Q.T. and Holmgren, R.A. 1999. The subcellular localization and activity of Diosophila cubitus interruptus are regulated at multiple levels. Development 126: 5097-5106.
48. -. 2000. Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development 127: 3131-3139.
49. Wang, G., Wang, B., and Jiang, J. 1999. Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes & Dev. 13: 2828-2837.
50. Wang, G., Amanai, K., Wang, B., and Jiang, J. 2000. Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes & Dev. 14: 2893-2905.
51. Xu, T. and Rubin, G.M. 1993. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.
52. Zhu, A.J., Zheng, L., Suyama, K., and Scott, M.P. 2003. Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes & Dev. 17: 1240-1252.