Gli3 mutation rescues the generation, but not the differentiation, of oligodendrocytes in Shh mutants

Brain Research

Volumn 1067, Issue 1, 2006, Pages 158-163

  Tan, Min ^a   Hu, Xuemei ^a   Qi, Yingchuan ^a   Park, Jinsil ^a   Cai, Jun ^a   Qiu, Mengsheng ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Development; Differentiation; Oligodendrocyte; Specification; Spinal cord

Indexed keywords

SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI3; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE MUTATION; MOUSE; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA HYBRIDIZATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; HEDGEHOG PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; OLIGODENDROGLIA; TRANS-ACTIVATORS;

ANIMALIA; ERINACEIDAE;

EID: 31144469120     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.10.041     Document Type: Article

References (20)

1. J allele generates a Gli3 fusion transcript Mamm. Genome 9 1998 676 678
2. J. Cai, Y. Qi, X. Hu, M. Tan, Z. Liu, J. Zhang, Q. Li, M. Sander, and M. Qiu Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6-regulation and Shh signaling Neuron 45 2005 41 53
3. C. Chiang, Y. Litingtung, E. Lee, K.E. Young, J.L. Corden, H. Westphal, and P.A. Beachy Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function Nature 383 1996 407 413
4. Q. Ding, J. Motoyama, S. Gasca, R. Mo, H. Sasaki, J. Rossant, and C.-C. Hui Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice Development 125 1998 2533 2543
5. J mutation contains an intragenic deletion of the Gli3 gene Nat. Genet. 3 1993 241 246
6. C.-C. Hui, D. Slusarski, K.A. Platt, R. Holmgren, and A.L. Joyner Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development Dev. Biol. 162 1994 402 413
7. Q. Lei, A.K. Zelman, E. Kuang, S. Li, and M.P. Matise Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord Development 131 2004 3593 3604
8. Y. Litingtung, and C. Chiang Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3 Nat. Neurosci. 3 2000 979 985
9. R. Liu, J. Cai, X. Hu, Y. Qi, M. Tan, M. Sander, and M. Qiu Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor Development 130 2003 6221 6231
10. M. Matise, D. Epstein, H. Park, K. Platt, and A. Joyner Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system Development 125 1998 2759 2770
11. D.M. Orentas, J.E. Hayes, K.L. Dyer, and R.H. Miller Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors Development 126 1999 2419 2429
12. H.L. Park, C. Bai, K.A. Platt, M.P. Matise, A. Beeghly, C.-C. Hui, M. Nakashima, and A.L. Joyner Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation Development 27 2000 1593 1605
13. M. Persson, D. Stamataki, P. Welscher, E. Andersson, J. Bose, U. Ruther, J. Ericson, and J. Briscoe Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity Genes Dev. 16 2002 2865 2878
14. Y. Qi, M. Tan, C.-C. Hui, and M. Qiu Gli2 activity is required for normal Shh signaling and oligodendrocyte development Mol. Cell. Neurosci. 23 2003 440 450
15. W. Richardson, H. Smith, T. Sun, N. Pringle, A. Hall, and R. Woodruff Oligodendrocyte lineage and the motor neuron connection Glia 29 2000 136 142
16. A. Ruiz, I. Altaba, V. Palma, and N. Dahmane Hedgehog-Gli signalling and the growth of the brain Nat. Rev., Neurosci. 3 2002 24 33
17. N. Schaeren-Wiemers, and A. Gerfin-Moser A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labeled cRNA probes Histochemistry 100 1993 431 440
18. C. Stolt, S. Rehberg, M. Ader, P. Lommes, D. Riethmacher, M. Schachner, U. Bartsch, and M. Wegner Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10 Genes Dev. 16 2002 165 170
19. O. Tyurina, B. Guner, E. Popova, J. Feng, A. Schier, J. Kohtz, and R. Karlstrom Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling Dev. Biol. 277 2005 537 556
20. A. Vallstedt, J.M. Klos, and J. Ericson Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain Neuron 45 2005 55 67