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Volumn 66, Issue 14, 2006, Pages 6964-6971

Patched2 modulates tumorigenesis in Patched1 heterozygous mice

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN PATCHED 1; PROTEIN PATCHED 2; SONIC HEDGEHOG PROTEIN;

EID: 33746879125     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-0505     Document Type: Article
Times cited : (86)

References (47)
  • 2
    • 0036559186 scopus 로고    scopus 로고
    • Gli and hedgehog in cancer: Tumours, embryos and stem cells
    • Ruiz I, Altaba A, Sanchez P, Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer 2002;2:361-72.
    • (2002) Nat Rev Cancer , vol.2 , pp. 361-372
    • Ruiz, I.1    Altaba, A.2    Sanchez, P.3    Dahmane, N.4
  • 3
    • 0034927062 scopus 로고    scopus 로고
    • The developmental biology of brain tumors
    • Wechsler-Reya R, Scott MP. The developmental biology of brain tumors. Annu Rev Neurosci 2001;24:385-428.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 385-428
    • Wechsler-Reya, R.1    Scott, M.P.2
  • 4
    • 0242268525 scopus 로고    scopus 로고
    • Wide-spread requirement for hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman DM, Karhadkar SS, Maitra A, et al. Wide-spread requirement for hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003;425:846-51.
    • (2003) Nature , vol.425 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3
  • 5
    • 2942738996 scopus 로고    scopus 로고
    • The hedgehog response network: Sensors, switches, and routers
    • Lum L, Beachy PA. The hedgehog response network: sensors, switches, and routers. Science 2004;304:1755-9.
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 6
    • 0141673242 scopus 로고    scopus 로고
    • The emergent design of the neural tube: Prepattern, shh morphogen and gli code
    • Ruiz I, Altaba A, Nguyen V, Palma V. The emergent design of the neural tube: prepattern, shh morphogen and gli code. Curr Opin Genet Dev 2003;13:513-21.
    • (2003) Curr Opin Genet Dev , vol.13 , pp. 513-521
    • Ruiz, I.1    Altaba, A.2    Nguyen, V.3    Palma, V.4
  • 7
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    • Watkins DN, Berman DM, Burkholder SG, et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003;422:313-7.
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1    Berman, D.M.2    Burkholder, S.G.3
  • 8
    • 15844386165 scopus 로고    scopus 로고
    • Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    • Hahn H, Wicking C, Zaphiropoulous PG. et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996;85:841-51.
    • (1996) Cell , vol.85 , pp. 841-851
    • Hahn, H.1    Wicking, C.2    Zaphiropoulous, P.G.3
  • 9
    • 15844381336 scopus 로고    scopus 로고
    • Human homolog of patched, a candidate gene for the basal cell nevus syndrome
    • Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996;272:1668-71.
    • (1996) Science , vol.272 , pp. 1668-1671
    • Johnson, R.L.1    Rothman, A.L.2    Xie, J.3
  • 10
    • 0036648241 scopus 로고    scopus 로고
    • Mutations in sufu predispose to medulloblastoma
    • Taylor MD, Liu L, Raffel C, et al. Mutations in sufu predispose to medulloblastoma. Nat Genet 2002;31:306-10.
    • (2002) Nat Genet , vol.31 , pp. 306-310
    • Taylor, M.D.1    Liu, L.2    Raffel, C.3
  • 12
    • 0033990220 scopus 로고    scopus 로고
    • Analysis of ptch/smo/shh pathway genes in medulloblastoma
    • Zurawel RH, Allen C, Chiappa S, et al. Analysis of ptch/smo/shh pathway genes in medulloblastoma. Genes Chromosomes Cancer 2000;27:44-51.
    • (2000) Genes Chromosomes Cancer , vol.27 , pp. 44-51
    • Zurawel, R.H.1    Allen, C.2    Chiappa, S.3
  • 13
    • 0034655270 scopus 로고    scopus 로고
    • The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched
    • Wetmore C, Eberhart DE. Curran T. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched. Cancer Res 2000;60:2239-46.
    • (2000) Cancer Res , vol.60 , pp. 2239-2246
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 14
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich LV, Milenkovic L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997;277:1109-13.
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 15
    • 0141816821 scopus 로고    scopus 로고
    • A molecular fingerprint for medulloblastoma
    • Lee Y, Miller HL, Jensen P, et al. A molecular fingerprint for medulloblastoma. Cancer Res 2003;63:5428-37.
    • (2003) Cancer Res , vol.63 , pp. 5428-5437
    • Lee, Y.1    Miller, H.L.2    Jensen, P.3
  • 16
    • 27744450224 scopus 로고    scopus 로고
    • The tumor suppressors ink4c and p53 collaborate independently with patched to suppress medulloblastoma formation
    • Uziel T, Zindy F, Xie S, et al. The tumor suppressors ink4c and p53 collaborate independently with patched to suppress medulloblastoma formation. Genes Dev 2005;19:2656-67.
    • (2005) Genes Dev , vol.19 , pp. 2656-2667
    • Uziel, T.1    Zindy, F.2    Xie, S.3
  • 17
    • 13644258035 scopus 로고    scopus 로고
    • Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCR
    • Levy P, Vidaud D, Leroy K, et al. Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCR. Mol Cancer 2004;3:20.
    • (2004) Mol Cancer , vol.3 , pp. 20
    • Levy, P.1    Vidaud, D.2    Leroy, K.3
  • 18
    • 12144288863 scopus 로고    scopus 로고
    • Distinct roles of ptch2 splice variants in hedgehog signalling
    • Rahnama F, Toftgard R, Zaphiropoulos PC. Distinct roles of ptch2 splice variants in hedgehog signalling. Biochem J 2004;378:325-34.
    • (2004) Biochem J , vol.378 , pp. 325-334
    • Rahnama, F.1    Toftgard, R.2    Zaphiropoulos, P.C.3
  • 19
    • 0032898184 scopus 로고    scopus 로고
    • Isolation and characterization of human patched 2 (ptch2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32
    • Smyth I, Narang MA, Evans T, et al. Isolation and characterization of human patched 2 (ptch2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32. Hum Mol Genet 1999;8:291-7.
    • (1999) Hum Mol Genet , vol.8 , pp. 291-297
    • Smyth, I.1    Narang, M.A.2    Evans, T.3
  • 20
    • 0032146093 scopus 로고    scopus 로고
    • Identification of a consistent region of allelic loss on 1p32 in meningiomas: Correlation with increased morbidity
    • Sulman EP, Dumanski JP, White PS, et al. Identification of a consistent region of allelic loss on 1p32 in meningiomas: correlation with increased morbidity. Cancer Res 1998;58:3226-30.
    • (1998) Cancer Res , vol.58 , pp. 3226-3230
    • Sulman, E.P.1    Dumanski, J.P.2    White, P.S.3
  • 21
    • 1342280365 scopus 로고    scopus 로고
    • Genomic annotation of the meningioma tumor suppressor locus on chromosome 1p34
    • Sulman EP, White PS, Brodeur GM. Genomic annotation of the meningioma tumor suppressor locus on chromosome 1p34. Oncogene 2004;23:1014-20.
    • (2004) Oncogene , vol.23 , pp. 1014-1020
    • Sulman, E.P.1    White, P.S.2    Brodeur, G.M.3
  • 22
    • 0033557853 scopus 로고    scopus 로고
    • Ptch2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas
    • Zaphiropoulos PG, Unden AB, Rahnama F, Hollingsworth RE, Toftgard R. Ptch2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas. Cancer Res 1999;59:787-92.
    • (1999) Cancer Res , vol.59 , pp. 787-792
    • Zaphiropoulos, P.G.1    Unden, A.B.2    Rahnama, F.3    Hollingsworth, R.E.4    Toftgard, R.5
  • 23
    • 0036048904 scopus 로고    scopus 로고
    • Genomic structure and refined chromosomal localization of the mouse ptch2 gene
    • Frohlich L, Liu Z, Beier DR, Lanske B. Genomic structure and refined chromosomal localization of the mouse ptch2 gene. Cytogenet Genome Res 2002;97:106-10.
    • (2002) Cytogenet Genome Res , vol.97 , pp. 106-110
    • Frohlich, L.1    Liu, Z.2    Beier, D.R.3    Lanske, B.4
  • 24
    • 0031647943 scopus 로고    scopus 로고
    • Overlapping and non-overlapping ptch2 expression with shh during mouse embryogenesis
    • Motoyama J, Heng H, Crackower MA, et al. Overlapping and non-overlapping ptch2 expression with shh during mouse embryogenesis. Mech Dev 1998;78:81-4.
    • (1998) Mech Dev , vol.78 , pp. 81-84
    • Motoyama, J.1    Heng, H.2    Crackower, M.A.3
  • 25
    • 0031989439 scopus 로고    scopus 로고
    • Ptch2, a second mouse patched gene is co-expressed with sonic hedgehog
    • Motoyama J, Takabatake T, Takeshima K, Hui C. Ptch2, a second mouse patched gene is co-expressed with sonic hedgehog. Nat Genet 1998;18:104-6.
    • (1998) Nat Genet , vol.18 , pp. 104-106
    • Motoyama, J.1    Takabatake, T.2    Takeshima, K.3    Hui, C.4
  • 26
    • 0032506115 scopus 로고    scopus 로고
    • Characterization of two patched receptors for the vertebrate hedgehog protein family
    • Carpenter D, Stone DM, Brush J, et al. Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci U S A 1998;95:13630-4.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13630-13634
    • Carpenter, D.1    Stone, D.M.2    Brush, J.3
  • 27
    • 0035863498 scopus 로고    scopus 로고
    • Loss of p53 but not arf accelerates medulloblastoma in mice heterozygous for patched
    • Wetmore C, Eberhart DE, Curran T. Loss of p53 but not arf accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 2001;61:513-6.
    • (2001) Cancer Res , vol.61 , pp. 513-516
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 28
    • 33645002415 scopus 로고    scopus 로고
    • Ptc1 heterozygous knockout mice as a model of multi-organ tumorigenesis
    • Pazzaglia S. Ptc1 heterozygous knockout mice as a model of multi-organ tumorigenesis. Cancer Lett 2006;234:124-34.
    • (2006) Cancer Lett , vol.234 , pp. 124-134
    • Pazzaglia, S.1
  • 29
    • 0031837454 scopus 로고    scopus 로고
    • Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
    • Hahn H, Wojnowski L, Zimmer AM, et al. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med 1998;4:619-22.
    • (1998) Nat Med , vol.4 , pp. 619-622
    • Hahn, H.1    Wojnowski, L.2    Zimmer, A.M.3
  • 30
    • 21044435675 scopus 로고    scopus 로고
    • Loss of patched and disruption of granule cell development in a preneoplastic stage of medulloblastoma
    • Oliver TG, Read TA, Kessler JD, et al. Loss of patched and disruption of granule cell development in a preneoplastic stage of medulloblastoma. Development 2005;132:2425-39.
    • (2005) Development , vol.132 , pp. 2425-2439
    • Oliver, T.G.1    Read, T.A.2    Kessler, J.D.3
  • 31
    • 0029777408 scopus 로고    scopus 로고
    • Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function
    • Chiang C, Litingtung Y, Lee E, et al. Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function. Nature 1996;383:407-13.
    • (1996) Nature , vol.383 , pp. 407-413
    • Chiang, C.1    Litingtung, Y.2    Lee, E.3
  • 32
    • 0031711075 scopus 로고    scopus 로고
    • Sonic hedgehog is essential to foregut development
    • Litingtung Y, Lei L, Westphal H, Chiang C. Sonic hedgehog is essential to foregut development. Nat Genet 1998;20:58-61.
    • (1998) Nat Genet , vol.20 , pp. 58-61
    • Litingtung, Y.1    Lei, L.2    Westphal, H.3    Chiang, C.4
  • 33
    • 16144368562 scopus 로고    scopus 로고
    • Identification of sonic hedgehog as a candidate gene responsible for holoprosencephaly
    • Belloni E, Muenke M, Roessler E, et al. Identification of sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat Genet 1996;14:353-6.
    • (1996) Nat Genet , vol.14 , pp. 353-356
    • Belloni, E.1    Muenke, M.2    Roessler, E.3
  • 34
    • 0030294408 scopus 로고    scopus 로고
    • Mutations in the human sonic hedgehog gene cause holoprosencephaly
    • Roessler E, Belloni E, Gaudenz K, et al. Mutations in the human sonic hedgehog gene cause holoprosencephaly. Nat Genet 1996;14:357-60.
    • (1996) Nat Genet , vol.14 , pp. 357-360
    • Roessler, E.1    Belloni, E.2    Gaudenz, K.3
  • 35
    • 0036556309 scopus 로고    scopus 로고
    • Mutations in patched-1, the receptor for sonic hedgehog, are associated with holoprosencephaly
    • Ming JE, Kaupas ME, Roessler E, et al. Mutations in patched-1, the receptor for sonic hedgehog, are associated with holoprosencephaly. Hum Genet 2002;110:297-301.
    • (2002) Hum Genet , vol.110 , pp. 297-301
    • Ming, J.E.1    Kaupas, M.E.2    Roessler, E.3
  • 36
    • 27644584608 scopus 로고    scopus 로고
    • Cardiac and ens defects in a mouse with targeted disruption of suppressor of fused
    • Cooper AF, Yu KP, Brueckner M, et al. Cardiac and ens defects in a mouse with targeted disruption of suppressor of fused. Development 2005;132:4407-17.
    • (2005) Development , vol.132 , pp. 4407-4417
    • Cooper, A.F.1    Yu, K.P.2    Brueckner, M.3
  • 37
    • 0030111258 scopus 로고    scopus 로고
    • Sertoli cell signaling by desert hedgehog regulates the male germline
    • Bitgood MJ, Shen L, McMahon AP. Sertoli cell signaling by desert hedgehog regulates the male germline. Curr Biol 1996;6:298-304.
    • (1996) Curr Biol , vol.6 , pp. 298-304
    • Bitgood, M.J.1    Shen, L.2    McMahon, A.P.3
  • 38
    • 32044455785 scopus 로고    scopus 로고
    • Desert hedgehog-patched 2 expression in peripheral nerves during wallerian degeneration and regeneration
    • Bajestan SN, Umehara F, Shirahama Y, et al. Desert hedgehog-patched 2 expression in peripheral nerves during wallerian degeneration and regeneration. J Neurobiol 2006;66:243-55.
    • (2006) J Neurobiol , vol.66 , pp. 243-255
    • Bajestan, S.N.1    Umehara, F.2    Shirahama, Y.3
  • 39
    • 0037219382 scopus 로고    scopus 로고
    • Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice
    • Tong WM, Ohgaki H, Huang H, et al. Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice. Am J Pathol 2003;162:343-52.
    • (2003) Am J Pathol , vol.162 , pp. 343-352
    • Tong, W.M.1    Ohgaki, H.2    Huang, H.3
  • 40
    • 0037112505 scopus 로고    scopus 로고
    • DNA ligase iv suppresses medulloblastoma formation
    • Lee Y, McKinnon PJ. DNA ligase iv suppresses medulloblastoma formation. Cancer Res 2002;62:6395-9.
    • (2002) Cancer Res , vol.62 , pp. 6395-6399
    • Lee, Y.1    McKinnon, P.J.2
  • 41
    • 0037168206 scopus 로고    scopus 로고
    • High incidence of medulloblastoma following X-ray-irradiation of newborn ptc1 heterozygous mice
    • Pazzaglia S, Mancuso M, Atkinson MJ, et al. High incidence of medulloblastoma following X-ray-irradiation of newborn ptc1 heterozygous mice. Oncogene 2002;21:7580-4.
    • (2002) Oncogene , vol.21 , pp. 7580-7584
    • Pazzaglia, S.1    Mancuso, M.2    Atkinson, M.J.3
  • 42
    • 10744221671 scopus 로고    scopus 로고
    • Basal cell carcinoma and its development: Insights from radiation-induced tumors in ptch1-deficient mice
    • Mancuso M, Pazzaglia S, Tanori M, et al. Basal cell carcinoma and its development: insights from radiation-induced tumors in ptch1-deficient mice. Cancer Res 2004;64:934-41.
    • (2004) Cancer Res , vol.64 , pp. 934-941
    • Mancuso, M.1    Pazzaglia, S.2    Tanori, M.3
  • 43
    • 0030825508 scopus 로고    scopus 로고
    • Chromosomal imbalance maps of malignant solid tumors: A cytogenetic survey of 3185 neoplasms
    • Mertens F, Johansson B, Hoglund M, Mitelman F. Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms. Cancer Res 1997;57:2765-80.
    • (1997) Cancer Res , vol.57 , pp. 2765-2780
    • Mertens, F.1    Johansson, B.2    Hoglund, M.3    Mitelman, F.4
  • 44
    • 0028786695 scopus 로고
    • Deletion of 1p loci and microsatellite instability in colorectal polyps
    • Lothe RA, Andersen SN, Hofstad B, et al. Deletion of 1p loci and microsatellite instability in colorectal polyps. Genes Chromosomes Cancer 1995;14:182-8.
    • (1995) Genes Chromosomes Cancer , vol.14 , pp. 182-188
    • Lothe, R.A.1    Andersen, S.N.2    Hofstad, B.3
  • 45
    • 0030878418 scopus 로고    scopus 로고
    • Clinical investigation of neuroblastoma with partial deletion in the short arm of chromosome 1
    • Ohtsu K, Hiyama E, Ichikawa T, Matsuura Y, Yokoyama T. Clinical investigation of neuroblastoma with partial deletion in the short arm of chromosome 1. Clin Cancer Res 1997;3:1221-8.
    • (1997) Clin Cancer Res , vol.3 , pp. 1221-1228
    • Ohtsu, K.1    Hiyama, E.2    Ichikawa, T.3    Matsuura, Y.4    Yokoyama, T.5
  • 46
    • 0031964896 scopus 로고    scopus 로고
    • Molecular cytogenetic analysis of adult testicular germ cell tumours and identification of regions of consensus copy number change
    • Summersgill B, Goker H, Weber-Hall S, et al. Molecular cytogenetic analysis of adult testicular germ cell tumours and identification of regions of consensus copy number change. Br J Cancer 1998;77:305-13.
    • (1998) Br J Cancer , vol.77 , pp. 305-313
    • Summersgill, B.1    Goker, H.2    Weber-Hall, S.3


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