Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling

Development

Volumn 126, Issue 17, 1999, Pages 3915-3924

  Sasaki, Hiroshi ^a   Nishizaki, Yuriko ^a   Hui, Chi Chung ^b   Nakafuku, Masato ^c   Kondoh, Hisato ^a  

^a OSAKA UNIVERSITY   (Japan)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Gli1; Gli2; Gli3; HNF3 ; Mouse; Neural tube; Sonic hedgehog

Indexed keywords

REPRESSOR PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; GENE ACTIVATION; MOUSE; NEURAL TUBE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELLS, CULTURED; DNA PRIMERS; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; EMBRYONIC INDUCTION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NERVOUS SYSTEM; PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; XENOPUS PROTEINS; ZINC FINGERS;

EID: 0032848136     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Akimaru, H., Chen, Y., Dai, P., Hou, D.-X., Nonaka, M., Smolik, S. M., Armstrong, S., Goodman, R. H. and Ishii, S. (1997). Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature 386, 735-737.
2. Alexandre, C., Jacinto, A. and Ingham, P. W. (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev. 10, 2003-2013.
3. Aza-Blanc, P., Ramirez-Weber, F.-A., Laget, M-P., Schwanrtz, C. and Kornberg, T. B. (1997). Proteolysis that is inhibited by hedgehog targets Cubutus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.
4. Borycki, A.-G., Mendham, L. and C.P., E. J. (1998). Control of somite patterning by Sonic hedgehog and its downstream signal response genes. Development 125, 777-790.
5. Chen, Y., Gallaher, N., Goodman, R. H. and Smolik, S. M. (1998). Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. Proc. Natl. Acad. Sci. USA 95, 2349-54.
6. Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A. (1996). Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413.
7. Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M. and Ishii, S. (1999). Sonic hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274, 8143-8152.
8. Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J. and Hui, C. (1998). Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125, 2533-2543.
9. Domínguez, M., Brunner, M., Hafen, E. and Basler, K. (1996). Sending and recieveing the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science 272, 1621-1625.
10. Echelard, Y., D.J., E., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P. (1993). Sonic hedgenog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.
11. Ericson, J., Muhr, J., Placzek, M., Lints, T., Jessell, T. M, and Edlund, T. (1995). Sonic hedgehog induces the differentiation of ventral forbrain neurons: a common signal for ventral patterning within the neural tube. Cell 81, 747-756.
12. Forbes, A. J., Nakano, Y., Taylor, A. M. and Ingham, P. W. (1993). Genetic-analysis of hedgehog signalling in the Drosophila embryo. Development Supplement, 115-124.
13. Goodrich, L. V. and Scott, M. P. (1998). Hedgehog and patched in neural development and disease. Neuron 21, 1243-1257.
14. Hammerschmidt, M., Brook, A. and McMahon, A. (1997). The world according to hedgehog. Trends Genet. 13, 14-21.
15. Hogan, B. L. M., Constantini, F. and Lacy, E. (1986). Manipulating the Mouse Embryo. A Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
16. Hughes, D. C., Allen, J., Morley, G., Sutherland, K., Ahmed, W., Prosser, J., Lettice, L., Allen, G., Mattei, M. G., Farrall, M. and Hill, R. E. (1997). Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region. Genomics 39, 205-215.
17. Hui, C.-C., Slusarski, D., Platt, K. A., Holmgreen, R. and Joyner, A. L. (1994). Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2 and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol. 162, 402-413.
18. Hynes, M., Porter, J. A., Chiang, C., Chang, D., Tessier-Lavigne, M., Beachy, P. A. and Rosenthal, A. (1995). Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron 15, 35-44.
19. Hynes, M., Stone, D., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A. and Rosenthal, A. (1997). Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19, 15-26.
20. Kamachi, Y., Cheah, K. S. E. and Kondoh, H. (1999). Mechanism of regulatory target selection by the SOX high-mobility-group domain proteins as revealed by comparison of SOX1/2/3 and SOX9. Mol. Cell. Biol. (in press).
21. Karlstrom, R. O., Talbot, W. S. and Schier, A. F. (1999). Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning. Genes Dev. 13, 388-393.
22. Kinzler, K. W., Ruppert, J. M., Bigner, S. H. and Vogelstein, B. (1988). The GLI gene is a member of Krüppel family of zinc finger proteins. Nature 332, 371-374.
23. Krishnan, V., Pereira, F., Qiu, Y., Chen, C., Beachy, P., Tsai, S. and Tsai, M. (1997). Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science 278, 1947-1950.
24. Lee, J., Platt, K. A., Censullo, P. and Ruiz i Altaba, A. (1997). Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124, 1528-1537.
25. Liu, C., Yang, J., Yoon, J., Villavicencio, E., Pfendler, K., Walterhouse, D. and Iannaccone, P. (1998). Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway. Gene 209, 1-11.
26. Logan, C., Khoo, W. K., Cado, D. and Joyner, A. L. (1993) Two enchancer regions in the mouse En-2 locus direct expression to the mid/hindbrain region and mandibular myoblasts. Development 117, 905-916.
27. Marigo, V., Davey, R. A., Zuo, Y., Cunninghan, J. M. and Tabin, C. J. (1996a). Biochemical evidence that Patched is the Hedgehog receptor. Nature 384, 176-179.
28. Marigo, V., Johnson, R. L., Vortkamp, A. and Tabin, C. J. (1996b). Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol. 180, 273-283.
29. Marigo, V., Scott, M. P., Johnson, R. L., Goodrich, L. V. and Tabin, C. J. (1996c). Conservation in hedgehog signalling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development 122, 1225-1233.
30. Marti, E., Bumcrot, D. A., Takada, R. and McMahon, A. P. (1995a) Requirement of 19K form of Sonic hedgehog for inductionn of distinct ventral cell types in CNS explants. Nature 375, 322-325.
31. Marti, E., Takada, R., Bumcrot, D. A., Sasaki, H. and McMahon, A. P. (1995b). Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development 121, 2537-2547.
32. Matise, M., Epstein, D., Park, H., Platt, K. and Joyner, A. (1998). Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125, 2759-2770.
33. Nakagawa, Y., Kanako, T., Ogura, T., Suzuki, T., Torii, M., Kaibuchi, K., Arai, K.-I., Nakamura, S. and Nakafuku, M. (1996). Roles of cell-autonomous mechanisms for differential expression of region-specific transcription factors in neuroepithelial cells. Development 122, 2449-2464.
34. Ohlmeyer, T. J. and Kalderon, D. (1998). Hedgehog stimulates maturation of Cubitus interruptus into a labile transcrptional activator. Nature 396, 749-753.
35. Platt, K., Michaud, J. and Joyner, A. (1997). Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice. Mech. Dev. 62, 121-135.
36. Roelink, H., Porter, J., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A. and Jessell, T. M. (1995). Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81, 445-455.
37. Ruiz i Altaba, A. (1998). Combinatorial Gli gene function in floor plate and neural inductions by Sonic hedgehog. Development 125, 2203-2212.
38. Ruiz i Altaba, A., Placzek, M., Baldassare, M., Dodd, J. and Jessell, T. (1995). Early stages of notochord and floor plate development in the chick embryo defined by normal and induced expression of HNF-3β. Dev. Biol. 170, 299-313.
39. Ruppert, J. M., Kinzler, K. W., Wong, A. J., Bigner, S. H., Kao, F., Law, M. L., Seuanez, H. N., O'Brien, J. O. and Vogelstein, B. (1988). The GLI-Kruppel family of human genes. Mol. Cell. Biol. 8, 3104-3113.
40. Ruppert, J. M., Vogelstein, B., Arheden, K. and Kinzler, K. W. (1990). GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol. Cell. Biol. 10, 5408-5415.
41. Sasaki, H. and Hogan, B. L. M. (1994). HNF-3β as a regulator of floor plate development. Cell 76, 103-115.
42. Sasaki, H., Hui, C.-c., Nakafuku, M. and Kondoh, H. (1997). A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-1322.
43. Sekido, R., Murai, K., Kamachi, Y. and Kondoh, H. (1997). Two mechanisms in the action of repressor δEF1: binding site competition with an activator and active repression. Genes Cells 2, 771-783.
44. Stone, D. M., Hynes, M., Armanini, M., Swanson, T. A., Gu, Q., Johnson, R. L., Scott, M. P., Pennica, D., Goddard, A., Phillips, H., Noll, M., Hooper, J. E., de Sauvage, F. and Rosenthal, A. (1996). The tumour suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384, 126-134.
45. Thien, H., Buscher, D. and Ruther, U. (1996). Cloning and sequence analysis of the murine Gli3 cDNA. Biochim. Biophys. Acta. 1307, 267-169.
46. Tsuchida, T., Ensini, M., Morton, S. B., Baldassare, M., Edlund, T., Jessell, T. M. and Pfaff, S. L. (1994). Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79, 957-970.
47. Von Ohlen, T., Lessing, D., Nusse, R. and Hooper, J. E. (1997). Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc. Nat. Acad. Sci. USA 94, 2404-2409.
48. Wall, N. A., Blessing, M., Wright, C. V. E. and Hogan, B. L. M. (1993). Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (Bone Morphogenetic Protein-6). J. Cell Biol. 120, 493-502.
49. Yasui, K., Sasaki, H., Arakai, R. and Uemura, M. (1997). Distribution pattern of HNF-3β proteins in developing embryos of two mammalian species, the house shrew and the mouse. Dev. Growth Differ. 39, 667-676.
50. Yoon, J. W., Liu, C. Z., Yang, J. T., Swart, R., Iannaccone, P. and Walterhouse, D. (1998). GLI activates transcription through a helpes symplex viral protein 16-like activation domains. J. Biol. Chem. 273, 3496-3501.