The full-length unprocessed hedgehog protein is an active signaling molecule

Journal of Biological Chemistry

Volumn 285, Issue 4, 2010, Pages 2562-2568

  Tokhunts, Robert ^a   Singh, Samer ^a   Chu, Tehyen ^c   D'Angelo, Gisela ^f   Baubet, Valerie ^d   Goetz, John A ^a   Huang, Zhen ^a   Yuan, Ziqiang ^a   Ascano, Manuel ^a   Zavros, Yana ^e   Thérond, Pascal P ^f   Kunes, Sam ^c   Dahmane, Nadia ^d   Robbins, David J ^a,b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^c HARVARD UNIVERSITY   (United States)

^d WISTAR INSTITUTE   (United States)

^e UNIVERSITY OF CINCINNATI   (United States)

^f UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CLEAVAGE PRODUCTS; FULL-LENGTH PROTEINS; IN-CELL; IN-VITRO; METAZOAN DEVELOPMENT; PLASMA MEMBRANES; SIGNALING EVENTS; SIGNALING MOLECULES;

CELL MEMBRANES; CHOLESTEROL; SIGNALING;

PROTEINS;

SONIC HEDGEHOG PROTEIN; CELL SURFACE RECEPTOR; DROSOPHILA PROTEIN; HEDGEHOG PROTEIN, DROSOPHILA; PATCHED RECEPTORS; SHH PROTEIN, HUMAN;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELL TRANSPORT; CHICKEN; CONTROLLED STUDY; DROSOPHILA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN TRANSPORT; RABBIT; SIGNAL TRANSDUCTION; ANIMAL; CELL COMMUNICATION; CHEMISTRY; CHICK EMBRYO; GENE EXPRESSION REGULATION; GENETICS; HOLOPROSENCEPHALY; METABOLISM; MOLECULAR EVOLUTION; NEURAL TUBE; PATHOPHYSIOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ERINACEIDAE; METAZOA;

ANIMALS; CELL COMMUNICATION; CHICK EMBRYO; CHICKENS; DROSOPHILA; DROSOPHILA PROTEINS; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HOLOPROSENCEPHALY; HUMANS; MUTAGENESIS, SITE-DIRECTED; NEURAL TUBE; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RABBITS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77449105629     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.078626     Document Type: Article

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