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Volumn 164, Issue 6, 2011, Pages 500-514

Liver X Receptor: An oxysterol sensor and a major player in the control of lipogenesis

Author keywords

Fatty acid; Lipogenesis; Liver X Receptor (LXR); Oxysterol

Indexed keywords

BILE ACID; CARNITINE PALMITOYLTRANSFERASE I; CELL NUCLEUS RECEPTOR; CERAMIDE; CHOLINEPHOSPHOTRANSFERASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIACYLGLYCEROL; FARNESOID X RECEPTOR; FATTY ACID; GLUCAGON; HIGH DENSITY LIPOPROTEIN; HISTONE DEACETYLASE 1; HORMONE; INSULIN; INSULIN RECEPTOR; LIVER X RECEPTOR; OXYSTEROL; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; RETINOID X RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; SULFOTRANSFERASE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 80051474745     PISSN: 00093084     EISSN: 18732941     Source Type: Journal    
DOI: 10.1016/j.chemphyslip.2011.06.004     Document Type: Review
Times cited : (56)

References (221)
  • 2
    • 0030939116 scopus 로고    scopus 로고
    • Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms
    • L. Abu-Elheiga, D.B. Almarza-Ortega, A. Baldini, and S.J. Wakil Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms J. Biol. Chem. 272 1997 10669 10677
    • (1997) J. Biol. Chem. , vol.272 , pp. 10669-10677
    • Abu-Elheiga, L.1    Almarza-Ortega, D.B.2    Baldini, A.3    Wakil, S.J.4
  • 5
    • 0035970805 scopus 로고    scopus 로고
    • Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-coa carboxylase 2
    • DOI 10.1126/science.1056843
    • L. Abu-Elheiga, M.M. Matzuk, K.A. Abo-Hashema, and S.J. Wakil Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2 Science 291 2001 2613 2616 (Pubitemid 32249687)
    • (2001) Science , vol.291 , Issue.5513 , pp. 2613-2616
    • Abu-Elheiga, L.1    Matzuk, M.M.2    Abo-Hashema, K.A.H.3    Wakil, S.J.4
  • 8
    • 33748182901 scopus 로고    scopus 로고
    • Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease
    • DOI 10.1016/j.neurobiolaging.2005.08.010, PII S0197458005002393
    • O. Adighibe, S. Arepalli, J. Duckworth, J. Hardy, and F. Wavrant-De Vrieze Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease Neurobiol. Aging 27 2006 1431 1434 (Pubitemid 44313874)
    • (2006) Neurobiology of Aging , vol.27 , Issue.10 , pp. 1431-1434
    • Adighibe, O.1    Arepalli, S.2    Duckworth, J.3    Hardy, J.4    Wavrant-De Vrieze, F.5
  • 9
    • 33646145315 scopus 로고    scopus 로고
    • Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: Cloning, tissue distribution, gene structure, and enzymatic activity
    • A.K. Agarwal, R.I. Barnes, and A. Garg Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity Arch. Biochem. Biophys. 449 2006 64 76
    • (2006) Arch. Biochem. Biophys. , vol.449 , pp. 64-76
    • Agarwal, A.K.1    Barnes, R.I.2    Garg, A.3
  • 10
    • 34447104351 scopus 로고    scopus 로고
    • Functional characterization of human 1-acylglycerol-3-phosphate-O- acyltransferase isoform 9: Cloning, tissue distribution, gene structure, and enzymatic activity
    • DOI 10.1677/JOE-07-0027
    • A.K. Agarwal, S. Sukumaran, R. Bartz, R.I. Barnes, and A. Garg Functional characterization of human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 9: cloning, tissue distribution, gene structure, and enzymatic activity J. Endocrinol. 193 2007 445 457 (Pubitemid 47028695)
    • (2007) Journal of Endocrinology , vol.193 , Issue.3 , pp. 445-457
    • Agarwal, A.K.1    Sukumaran, S.2    Bartz, R.3    Barnes, R.I.4    Garg, A.5
  • 11
    • 1842584446 scopus 로고    scopus 로고
    • Do polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREPB-1 suppression or by correcting essential fatty acid deficiency
    • author reply 1177-1178
    • I.P. Alwayn, P.J. Javid, K.M. Gura, V. Nose, M. Ollero, and M. Puder Do polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREPB-1 suppression or by correcting essential fatty acid deficiency Hepatology 39 2004 1176 1177 author reply 1177-1178
    • (2004) Hepatology , vol.39 , pp. 1176-1177
    • Alwayn, I.P.1    Javid, P.J.2    Gura, K.M.3    Nose, V.4    Ollero, M.5    Puder, M.6
  • 12
    • 0030747895 scopus 로고    scopus 로고
    • Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: No alteration in adipose tissue of obese and NIDDM patients
    • D. Auboeuf, J. Rieusset, L. Fajas, P. Vallier, V. Frering, J.P. Riou, B. Staels, J. Auwerx, M. Laville, and H. Vidal Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients Diabetes 46 1997 1319 1327 (Pubitemid 27315281)
    • (1997) Diabetes , vol.46 , Issue.8 , pp. 1319-1327
    • Auboeuf, D.1    Rieusset, J.2    Fajas, L.3    Vallier, P.4    Frering, V.5    Riou, J.P.6    Staels, B.7    Auwerx, J.8    Laville, M.9    Vidal, H.10
  • 13
    • 79151476474 scopus 로고    scopus 로고
    • Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells
    • Q. Bai, L. Xu, G. Kakiyama, M.A. Runge-Morris, P.B. Hylemon, L. Yin, W.M. Pandak, and S. Ren Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells Atherosclerosis 214 2010 350 356
    • (2010) Atherosclerosis , vol.214 , pp. 350-356
    • Bai, Q.1    Xu, L.2    Kakiyama, G.3    Runge-Morris, M.A.4    Hylemon, P.B.5    Yin, L.6    Pandak, W.M.7    Ren, S.8
  • 15
    • 78649944880 scopus 로고    scopus 로고
    • Identification of 5alpha, 6alpha-epoxycholesterol as a novel modulator of liver X receptor activity
    • T.J. Berrodin, Q. Shen, E.M. Quinet, M.R. Yudt, L.P. Freedman, and S. Nagpal Identification of 5alpha, 6alpha-epoxycholesterol as a novel modulator of liver X receptor activity Mol. Pharmacol. 78 2010 1046 1058
    • (2010) Mol. Pharmacol. , vol.78 , pp. 1046-1058
    • Berrodin, T.J.1    Shen, Q.2    Quinet, E.M.3    Yudt, M.R.4    Freedman, L.P.5    Nagpal, S.6
  • 16
    • 34247139296 scopus 로고    scopus 로고
    • Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol
    • DOI 10.1074/jbc.M611063200
    • M.M. Beyea, C.L. Heslop, C.G. Sawyez, J.Y. Edwards, J.G. Markle, R.A. Hegele, and M.W. Huff Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol J. Biol. Chem. 282 2007 5207 5216 (Pubitemid 47093759)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.8 , pp. 5207-5216
    • Beyea, M.M.1    Heslop, C.L.2    Sawyez, C.G.3    Edwards, J.Y.4    Markle, J.G.5    Hegele, R.A.6    Huff, M.W.7
  • 17
    • 0037323903 scopus 로고    scopus 로고
    • Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors
    • K.U. Birkenkamp, and P.J. Coffer Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors Biochem. Soc. Trans. 31 2003 292 297 (Pubitemid 36241447)
    • (2003) Biochemical Society Transactions , vol.31 , Issue.1 , pp. 292-297
    • Birkenkamp, K.U.1    Coffer, P.J.2
  • 18
    • 33947706821 scopus 로고    scopus 로고
    • Rediscovery of cerebrosterol
    • DOI 10.1007/s11745-006-1003-2
    • I. Bjorkhem Rediscovery of cerebrosterol Lipids 42 2007 5 14 (Pubitemid 46490739)
    • (2007) Lipids , vol.42 , Issue.1 , pp. 5-14
    • Bjorkhem, I.1
  • 19
    • 0026438895 scopus 로고
    • Preferential cyclization of 2,3(S):22(S),23-dioxidosqualene by mammalian 2,3-oxidosqualene-lanosterol cyclase
    • O. Boutaud, D. Dolis, and F. Schuber Preferential cyclization of 2,3(S):22(S),23-dioxidosqualene by mammalian 2,3-oxidosqualene-lanosterol cyclase Biochem. Biophys. Res. Commun. 188 1992 898 904
    • (1992) Biochem. Biophys. Res. Commun. , vol.188 , pp. 898-904
    • Boutaud, O.1    Dolis, D.2    Schuber, F.3
  • 20
    • 0036716912 scopus 로고    scopus 로고
    • The small heterodimer partner interacts with the liver X receptor α and represses its transcriptional activity
    • DOI 10.1210/me.2001-0194
    • C. Brendel, K. Schoonjans, O.A. Botrugno, E. Treuter, and J. Auwerx The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity Mol. Endocrinol. 16 2002 2065 2076 (Pubitemid 35013455)
    • (2002) Molecular Endocrinology , vol.16 , Issue.9 , pp. 2065-2076
    • Brendel, C.1    Schoonjans, K.2    Botrugno, O.A.3    Treuter, E.4    Auwerx, J.5
  • 21
    • 78649855297 scopus 로고    scopus 로고
    • Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice
    • J. Bricambert, J. Miranda, F. Benhamed, J. Girard, C. Postic, and R. Dentin Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice J. Clin. Invest. 120 2010 4316 4331
    • (2010) J. Clin. Invest. , vol.120 , pp. 4316-4331
    • Bricambert, J.1    Miranda, J.2    Benhamed, F.3    Girard, J.4    Postic, C.5    Dentin, R.6
  • 22
    • 67349268463 scopus 로고    scopus 로고
    • Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis
    • A.J. Brown, and W. Jessup Oxysterols: sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis Mol. Aspects Med. 30 2009 111 122
    • (2009) Mol. Aspects Med. , vol.30 , pp. 111-122
    • Brown, A.J.1    Jessup, W.2
  • 23
    • 69249136669 scopus 로고    scopus 로고
    • Working towards an exegesis for lipids in biology
    • H.A. Brown, and R.C. Murphy Working towards an exegesis for lipids in biology Nat. Chem. Biol. 5 2009 602 606
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 602-606
    • Brown, H.A.1    Murphy, R.C.2
  • 24
    • 66349134748 scopus 로고    scopus 로고
    • Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL
    • M.S. Brown, and J.L. Goldstein Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL J. Lipid Res. 50 Suppl. 2009 S15 S27
    • (2009) J. Lipid Res. , vol.50 , Issue.SUPPL.
    • Brown, M.S.1    Goldstein, J.L.2
  • 25
    • 77955129487 scopus 로고    scopus 로고
    • Liver X receptor signaling pathways and atherosclerosis
    • A.C. Calkin, and P. Tontonoz Liver X receptor signaling pathways and atherosclerosis Arterioscler. Thromb. Vasc. Biol. 30 2010 1513 1518
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 1513-1518
    • Calkin, A.C.1    Tontonoz, P.2
  • 26
    • 51549107903 scopus 로고    scopus 로고
    • Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
    • H. Cao, K. Gerhold, J.R. Mayers, M.M. Wiest, S.M. Watkins, and G.S. Hotamisligil Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism Cell 134 2008 933 944
    • (2008) Cell , vol.134 , pp. 933-944
    • Cao, H.1    Gerhold, K.2    Mayers, J.R.3    Wiest, M.M.4    Watkins, S.M.5    Hotamisligil, G.S.6
  • 27
    • 33947104623 scopus 로고    scopus 로고
    • Catalytic properties of MGAT3, a putative triacylgycerol synthase
    • DOI 10.1194/jlr.M600331-JLR200
    • J. Cao, L. Cheng, and Y. Shi Catalytic properties of MGAT3, a putative triacylgycerol synthase J. Lipid Res. 48 2007 583 591 (Pubitemid 46397461)
    • (2007) Journal of Lipid Research , vol.48 , Issue.3 , pp. 583-591
    • Cao, J.1    Cheng, L.2    Shi, Y.3
  • 29
    • 59149106049 scopus 로고    scopus 로고
    • Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis
    • G.M. Carman, and G.S. Han Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis J. Biol. Chem. 284 2009 2593 2597
    • (2009) J. Biol. Chem. , vol.284 , pp. 2593-2597
    • Carman, G.M.1    Han, G.S.2
  • 32
    • 33847006599 scopus 로고    scopus 로고
    • The Liver X Receptor (LXR) and hepatic lipogenesis: The carbohydrate-response element-binding protein is a target gene of LXR
    • DOI 10.1074/jbc.M605023200
    • J.Y. Cha, and J.J. Repa The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR J. Biol. Chem. 282 2007 743 751 (Pubitemid 47076632)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.1 , pp. 743-751
    • Cha, J.-Y.1    Repa, J.J.2
  • 34
    • 22544480378 scopus 로고    scopus 로고
    • "New" hepatic fat activates PPARα to maintain glucose, lipid, and cholesterol homeostasis
    • DOI 10.1016/j.cmet.2005.04.002, PII S1550413105001105
    • M.V. Chakravarthy, Z. Pan, Y. Zhu, K. Tordjman, J.G. Schneider, T. Coleman, J. Turk, and C.F. Semenkovich "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis Cell Metab. 1 2005 309 322 (Pubitemid 43977168)
    • (2005) Cell Metabolism , vol.1 , Issue.5 , pp. 309-322
    • Chakravarthy, M.V.1    Pan, Z.2    Zhu, Y.3    Tordjman, K.4    Schneider, J.G.5    Coleman, T.6    Turk, J.7    Semenkovich, C.F.8
  • 36
    • 33845587711 scopus 로고    scopus 로고
    • Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice
    • DOI 10.1016/j.cmet.2006.11.012, PII S1550413106003950
    • W. Chen, G. Chen, D.L. Head, D.J. Mangelsdorf, and D.W. Russell Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice Cell Metab. 5 2007 73 79 (Pubitemid 44933109)
    • (2007) Cell Metabolism , vol.5 , Issue.1 , pp. 73-79
    • Chen, W.1    Chen, G.2    Head, D.L.3    Mangelsdorf, D.J.4    Russell, D.W.5
  • 38
    • 0035834868 scopus 로고    scopus 로고
    • Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα)
    • DOI 10.1016/S0378-1119(00)00518-7, PII S0378111900005187
    • J.Y. Chiang, R. Kimmel, and D. Stroup Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha) Gene 262 2001 257 265 (Pubitemid 32155357)
    • (2001) Gene , vol.262 , Issue.1-2 , pp. 257-265
    • Chiang, J.Y.L.1    Kimmel, R.2    Stroup, D.3
  • 41
    • 12344283741 scopus 로고    scopus 로고
    • Structure and function of animal fatty acid synthase
    • DOI 10.1007/s11745-004-1329-9
    • S.S. Chirala, and S.J. Wakil Structure and function of animal fatty acid synthase Lipids 39 2004 1045 1053 (Pubitemid 40129046)
    • (2004) Lipids , vol.39 , Issue.11 , pp. 1045-1053
    • Chirala, S.S.1    Wakil, S.J.2
  • 42
    • 33748655454 scopus 로고    scopus 로고
    • Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
    • DOI 10.1128/MCB.00077-06
    • K. Chu, M. Miyazaki, W.C. Man, and J.M. Ntambi Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation Mol. Cell. Biol. 26 2006 6786 6798 (Pubitemid 44387629)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.18 , pp. 6786-6798
    • Chu, K.1    Miyazaki, M.2    Man, W.C.3    Ntambi, J.M.4
  • 45
    • 0345171460 scopus 로고    scopus 로고
    • Enzymes of triacylglycerol synthesis and their regulation
    • DOI 10.1016/S0163-7827(03)00051-1
    • R.A. Coleman, and D.P. Lee Enzymes of triacylglycerol synthesis and their regulation Prog. Lipid Res. 43 2004 134 176 (Pubitemid 37492937)
    • (2004) Progress in Lipid Research , vol.43 , Issue.2 , pp. 134-176
    • Coleman, R.A.1    Lee, D.P.2
  • 48
    • 0034623288 scopus 로고    scopus 로고
    • Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
    • P. Costet, Y. Luo, N. Wang, and A.R. Tall Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor J. Biol. Chem. 275 2000 28240 28245
    • (2000) J. Biol. Chem. , vol.275 , pp. 28240-28245
    • Costet, P.1    Luo, Y.2    Wang, N.3    Tall, A.R.4
  • 53
    • 43649094366 scopus 로고    scopus 로고
    • Carbohydrate responsive element binding protein and lipid homeostasis
    • DOI 10.1097/MOL.0b013e3282ffafaa, PII 0004143320080600000014
    • P.D. Denechaud, J. Girard, and C. Postic Carbohydrate responsive element binding protein and lipid homeostasis Curr. Opin. Lipidol. 19 2008 301 306 (Pubitemid 351681558)
    • (2008) Current Opinion in Lipidology , vol.19 , Issue.3 , pp. 301-306
    • Denechaud, P.-D.1    Girard, J.2    Postic, C.3
  • 54
    • 26444434340 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation
    • DOI 10.1172/JCI25256
    • R. Dentin, F. Benhamed, J.P. Pegorier, F. Foufelle, B. Viollet, S. Vaulont, J. Girard, and C. Postic Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation J. Clin. Invest. 115 2005 2843 2854 (Pubitemid 41434411)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.10 , pp. 2843-2854
    • Dentin, R.1    Benhamed, F.2    Pegorier, J.-P.3    Foufelle, F.4    Viollet, B.5    Vaulont, S.6    Girard, J.7    Postic, C.8
  • 56
    • 0027968653 scopus 로고
    • Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2
    • D. Dollis, and F. Schuber Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2 Biochem. Pharmacol. 48 1994 49 57
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 49-57
    • Dollis, D.1    Schuber, F.2
  • 57
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • DOI 10.1172/JCI200523621
    • K.L. Donnelly, C.I. Smith, S.J. Schwarzenberg, J. Jessurun, M.D. Boldt, and E.J. Parks Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease J. Clin. Invest. 115 2005 1343 1351 (Pubitemid 40629054)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.5 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 58
    • 0030789284 scopus 로고    scopus 로고
    • Human lysophosphatidic acid acyltransferase: cDNA cloning, expression, and localization to chromosome 9q34.3
    • DOI 10.1074/jbc.272.32.20299
    • C. Eberhardt, P.W. Gray, and L.W. Tjoelker Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3 J. Biol. Chem. 272 1997 20299 20305 (Pubitemid 27340144)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.32 , pp. 20299-20305
    • Eberhardt, C.1    Gray, P.W.2    Tjoelker, L.W.3
  • 60
    • 35548996710 scopus 로고    scopus 로고
    • DisSIRTing on LXR and cholesterol metabolism
    • DOI 10.1016/j.cmet.2007.10.003, PII S1550413107002963
    • J.N. Feige, and J. Auwerx DisSIRTing on LXR and cholesterol metabolism Cell Metab. 6 2007 343 345 (Pubitemid 350012003)
    • (2007) Cell Metabolism , vol.6 , Issue.5 , pp. 343-345
    • Feige, J.N.1    Auwerx, J.2
  • 61
    • 77957302090 scopus 로고    scopus 로고
    • Hepatic steatosis: A role for de novo lipogenesis and the transcription factor SREBP-1c
    • P. Ferre, and F. Foufelle Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c Diabetes Obes. Metab. 12 Suppl. 2 2010 83 92
    • (2010) Diabetes Obes. Metab. , vol.12 , Issue.SUPPL. 2 , pp. 83-92
    • Ferre, P.1    Foufelle, F.2
  • 64
    • 53149118574 scopus 로고    scopus 로고
    • Sterol regulators of cholesterol homeostasis and beyond: The oxysterol hypothesis revisited and revised
    • S. Gill, R. Chow, and A.J. Brown Sterol regulators of cholesterol homeostasis and beyond: the oxysterol hypothesis revisited and revised Prog. Lipid Res. 47 2008 391 404
    • (2008) Prog. Lipid Res. , vol.47 , pp. 391-404
    • Gill, S.1    Chow, R.2    Brown, A.J.3
  • 65
    • 79952174597 scopus 로고    scopus 로고
    • Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase
    • S. Gill, J. Stevenson, I. Kristiana, and A.J. Brown Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase Cell Metab. 13 2011 260 273
    • (2011) Cell Metab. , vol.13 , pp. 260-273
    • Gill, S.1    Stevenson, J.2    Kristiana, I.3    Brown, A.J.4
  • 66
    • 66849089864 scopus 로고    scopus 로고
    • Thematic review series: Glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: New genes for an old activity
    • R.E. Gimeno, and J. Cao Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity J. Lipid Res. 49 2008 2079 2088
    • (2008) J. Lipid Res. , vol.49 , pp. 2079-2088
    • Gimeno, R.E.1    Cao, J.2
  • 67
    • 0034650893 scopus 로고    scopus 로고
    • The coregulator exchange in transcriptional functions of nuclear receptors
    • C.K. Glass, and M.G. Rosenfeld The coregulator exchange in transcriptional functions of nuclear receptors Genes Dev. 14 2000 121 141 (Pubitemid 30070977)
    • (2000) Genes and Development , vol.14 , Issue.2 , pp. 121-141
    • Glass, C.K.1    Rosenfeld, M.G.2
  • 68
    • 0039302500 scopus 로고    scopus 로고
    • A branched metabolic pathway in animal cells converts 2-monoacylglycerol into sn-1-stearoyl-2-arachidonoyl phosphatidylinositol and other phosphoglycerides
    • R.W. Gross, Elsevier St. Louis, MO
    • J.A. Glosset A branched metabolic pathway in animal cells converts 2-monoacylglycerol into sn-1-stearoyl-2-arachidonoyl phosphatidylinositol and other phosphoglycerides R.W. Gross, Advances in Lipobiology vol. 1 1996 Elsevier St. Louis, MO 61 100
    • (1996) Advances in Lipobiology , vol.1 , pp. 61-100
    • Glosset, J.A.1
  • 71
    • 0026551309 scopus 로고
    • Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor
    • M. Gottlicher, E. Widmark, Q. Li, and J.A. Gustafsson Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor Proc. Natl. Acad. Sci. U.S.A. 89 1992 4653 4657
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 4653-4657
    • Gottlicher, M.1    Widmark, E.2    Li, Q.3    Gustafsson, J.A.4
  • 73
    • 76749132709 scopus 로고    scopus 로고
    • The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice
    • H. Guillou, D. Zadravec, P.G. Martin, and A. Jacobsson The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice Prog. Lipid Res. 49 2010 186 199
    • (2010) Prog. Lipid Res. , vol.49 , pp. 186-199
    • Guillou, H.1    Zadravec, D.2    Martin, P.G.3    Jacobsson, A.4
  • 74
    • 0036889152 scopus 로고    scopus 로고
    • Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition
    • DOI 10.1128/MCB.22.23.8204-8214.2002
    • L.E. Hammond, P.A. Gallagher, S. Wang, S. Hiller, K.D. Kluckman, E.L. Posey-Marcos, N. Maeda, and R.A. Coleman Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition Mol. Cell. Biol. 22 2002 8204 8214 (Pubitemid 35304054)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.23 , pp. 8204-8214
    • Hammond, L.E.1    Gallagher, P.A.2    Wang, S.3    Hiller, S.4    Kluckman, K.D.5    Posey-Marcos, E.L.6    Maeda, N.7    Coleman, R.A.8
  • 77
    • 0035830840 scopus 로고    scopus 로고
    • Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells
    • V.C. Hannah, J. Ou, A. Luong, J.L. Goldstein, and M.S. Brown Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells J. Biol. Chem. 276 2001 4365 4372
    • (2001) J. Biol. Chem. , vol.276 , pp. 4365-4372
    • Hannah, V.C.1    Ou, J.2    Luong, A.3    Goldstein, J.L.4    Brown, M.S.5
  • 80
    • 35649023189 scopus 로고    scopus 로고
    • The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor
    • DOI 10.1210/me.2007-0213
    • B. Herzog, M. Hallberg, A. Seth, A. Woods, R. White, and M.G. Parker The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor Mol. Endocrinol. 21 2007 2687 2697 (Pubitemid 350035151)
    • (2007) Molecular Endocrinology , vol.21 , Issue.11 , pp. 2687-2697
    • Herzog, B.1    Hallberg, M.2    Seth, A.3    Woods, A.4    White, R.5    Parker, M.G.6
  • 83
    • 79953177493 scopus 로고    scopus 로고
    • Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: Identification of ARL7 as a direct target
    • C. Hong, R. Walczak, H. Dhamko, M.N. Bradley, C. Marathe, R. Boyadjian, J.V. Salazar, and P. Tontonoz Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target J. Lipid Res. 52 2011 531 539
    • (2011) J. Lipid Res. , vol.52 , pp. 531-539
    • Hong, C.1    Walczak, R.2    Dhamko, H.3    Bradley, M.N.4    Marathe, C.5    Boyadjian, R.6    Salazar, J.V.7    Tontonoz, P.8
  • 84
    • 0032104180 scopus 로고    scopus 로고
    • Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2
    • J.D. Horton, I. Shimomura, M.S. Brown, R.E. Hammer, J.L. Goldstein, and H. Shimano Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2 J. Clin. Invest. 101 1998 2331 2339 (Pubitemid 28270427)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.11 , pp. 2331-2339
    • Norton, J.D.1    Shimomura, I.2    Brown, M.S.3    Hammer, R.E.4    Goldstein, J.L.5    Shimano, H.6
  • 87
    • 73949159619 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRalpha
    • G. Howell III, X. Deng, C. Yellaturu, E.A. Park, H.G. Wilcox, R. Raghow, and M.B. Elam N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRalpha Biochim. Biophys. Acta 1791 2009 1190 1196
    • (2009) Biochim. Biophys. Acta , vol.1791 , pp. 1190-1196
    • Howell Iii, G.1    Deng, X.2    Yellaturu, C.3    Park, E.A.4    Wilcox, H.G.5    Raghow, R.6    Elam, M.B.7
  • 88
    • 0038517917 scopus 로고    scopus 로고
    • Liver X receptors interact with corepressors to regulate gene expression
    • DOI 10.1210/me.2002-0399
    • X. Hu, S. Li, J. Wu, C. Xia, and D.S. Lala Liver X receptors interact with corepressors to regulate gene expression Mol. Endocrinol. 17 2003 1019 1026 (Pubitemid 36683710)
    • (2003) Molecular Endocrinology , vol.17 , Issue.6 , pp. 1019-1026
    • Hu, X.1    Li, S.2    Wu, J.3    Xia, C.4    Lala, D.S.5
  • 92
    • 70649093097 scopus 로고    scopus 로고
    • Lipidomics: A mass spectrometry based systems level analysis of cellular lipids
    • P.T. Ivanova, S.B. Milne, D.S. Myers, and H.A. Brown Lipidomics: a mass spectrometry based systems level analysis of cellular lipids Curr. Opin. Chem. Biol. 13 2009 526 531
    • (2009) Curr. Opin. Chem. Biol. , vol.13 , pp. 526-531
    • Ivanova, P.T.1    Milne, S.B.2    Myers, D.S.3    Brown, H.A.4
  • 94
    • 0035976936 scopus 로고    scopus 로고
    • The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols
    • B.A. Janowski, B. Shan, and D.W. Russell The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols J. Biol. Chem. 276 2001 45408 45416
    • (2001) J. Biol. Chem. , vol.276 , pp. 45408-45416
    • Janowski, B.A.1    Shan, B.2    Russell, D.W.3
  • 95
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXRα
    • DOI 10.1038/383728a0
    • B.A. Janowski, P.J. Willy, T.R. Devi, J.R. Falck, and D.J. Mangelsdorf An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha Nature 383 1996 728 731 (Pubitemid 26360651)
    • (1996) Nature , vol.383 , Issue.6602 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3    Falck, J.R.4    Mangelsdorf, D.J.5
  • 96
    • 33845595443 scopus 로고    scopus 로고
    • Regulation of ABCA1 expression in human keratinocytes and murine epidermis
    • DOI 10.1194/jlr.M600163-JLR200
    • Y.J. Jiang, B. Lu, P. Kim, P.M. Elias, and K.R. Feingold Regulation of ABCA1 expression in human keratinocytes and murine epidermis J. Lipid Res. 47 2006 2248 2258 (Pubitemid 44936135)
    • (2006) Journal of Lipid Research , vol.47 , Issue.10 , pp. 2248-2258
    • Jiang, Y.J.1    Lu, B.2    Kim, P.3    Elias, P.M.4    Feingold, K.R.5
  • 97
    • 0035937783 scopus 로고    scopus 로고
    • Multiple N-CoR complexes contain distinct histone deacetylases
    • P.L. Jones, L.M. Sachs, N. Rouse, P.A. Wade, and Y.B. Shi Multiple N-CoR complexes contain distinct histone deacetylases J. Biol. Chem. 276 2001 8807 8811
    • (2001) J. Biol. Chem. , vol.276 , pp. 8807-8811
    • Jones, P.L.1    Sachs, L.M.2    Rouse, N.3    Wade, P.A.4    Shi, Y.B.5
  • 99
    • 0032814457 scopus 로고    scopus 로고
    • Regulation of gene expression by dietary fat
    • DOI 10.1146/annurev.nutr.19.1.63
    • D.B. Jump, and S.D. Clarke Regulation of gene expression by dietary fat Annu. Rev. Nutr. 19 1999 63 90 (Pubitemid 29380597)
    • (1999) Annual Review of Nutrition , vol.19 , pp. 63-90
    • Jump, D.B.1    Clarke, S.D.2
  • 101
    • 0024427057 scopus 로고
    • Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase
    • K.H. Kaestner, J.M. Ntambi, T.J. Kelly Jr., and M.D. Lane Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase J. Biol. Chem. 264 1989 14755 14761 (Pubitemid 19237293)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.25 , pp. 14755-14761
    • Kaestner, K.H.1    Ntambi, J.M.2    Kelly Jr., T.J.3    Lane, M.D.4
  • 103
    • 66449137379 scopus 로고    scopus 로고
    • GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    • H.L. Kammoun, H. Chabanon, I. Hainault, S. Luquet, C. Magnan, T. Koike, P. Ferre, and F. Foufelle GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice J. Clin. Invest. 119 2009 1201 1215
    • (2009) J. Clin. Invest. , vol.119 , pp. 1201-1215
    • Kammoun, H.L.1    Chabanon, H.2    Hainault, I.3    Luquet, S.4    Magnan, C.5    Koike, T.6    Ferre, P.7    Foufelle, F.8
  • 104
    • 0141481039 scopus 로고    scopus 로고
    • Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist
    • DOI 10.1074/jbc.M304153200
    • E. Kaneko, M. Matsuda, Y. Yamada, Y. Tachibana, I. Shimomura, and M. Makishima Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist J. Biol. Chem. 278 2003 36091 36098 (Pubitemid 37139930)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.38 , pp. 36091-36098
    • Kaneko, E.1    Matsuda, M.2    Yamada, Y.3    Tachibana, Y.4    Shimomura, I.5    Makishima, M.6
  • 105
    • 0347034082 scopus 로고    scopus 로고
    • Characterization of the human ABCG1 gene. Liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein
    • DOI 10.1074/jbc.M105863200
    • M.A. Kennedy, A. Venkateswaran, P.T. Tarr, I. Xenarios, J. Kudoh, N. Shimizu, and P.A. Edwards Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein J. Biol. Chem. 276 2001 39438 39447 (Pubitemid 37371322)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.42 , pp. 39438-39447
    • Kennedy, M.A.1    Venkateswaran, A.2    Tarr, P.T.3    Xenarios, I.4    Kudoh, J.5    Shimizu, N.6    Edwards, P.A.7
  • 111
    • 0035914412 scopus 로고    scopus 로고
    • DGAT2 is a new diacylglycerol acyltransferase gene family: Purification, cloning, and expression in insect cells of two polypeptides from Mortierella ramanniana with diacylglycerol acyltransferase activity
    • K.D. Lardizabal, J.T. Mai, N.W. Wagner, A. Wyrick, T. Voelker, and D.J. Hawkins DGAT2 is a new diacylglycerol acyltransferase gene family: purification, cloning, and expression in insect cells of two polypeptides from Mortierella ramanniana with diacylglycerol acyltransferase activity J. Biol. Chem. 276 2001 38862 38869
    • (2001) J. Biol. Chem. , vol.276 , pp. 38862-38869
    • Lardizabal, K.D.1    Mai, J.T.2    Wagner, N.W.3    Wyrick, A.4    Voelker, T.5    Hawkins, D.J.6
  • 112
    • 12944259150 scopus 로고    scopus 로고
    • Nutritional regulation of the fatty acid synthase promoter in vivo: Sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element
    • M.J. Latasa, Y.S. Moon, K.H. Kim, and H.S. Sul Nutritional regulation of the fatty acid synthase promoter in vivo: sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element Proc. Natl. Acad. Sci. U.S.A. 97 2000 10619 10624
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 10619-10624
    • Latasa, M.J.1    Moon, Y.S.2    Kim, K.H.3    Sul, H.S.4
  • 113
    • 44649177124 scopus 로고    scopus 로고
    • Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors
    • DOI 10.1210/me.2008-0012
    • S. Lee, J. Lee, S.K. Lee, and J.W. Lee Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors Mol. Endocrinol. 22 2008 1312 1319 (Pubitemid 351786992)
    • (2008) Molecular Endocrinology , vol.22 , Issue.6 , pp. 1312-1319
    • Lee, S.1    Lee, J.2    Lee, S.-K.3    Lee, J.W.4
  • 115
    • 0010044876 scopus 로고    scopus 로고
    • The structure and functions of human lysophosphatidic acid acyltransferases
    • D.W. Leung The structure and functions of human lysophosphatidic acid acyltransferases Front. Biosci. 6 2001 D944 953
    • (2001) Front. Biosci. , vol.6 , pp. 944-953
    • Leung, D.W.1
  • 116
    • 1842741311 scopus 로고    scopus 로고
    • Identification of a New Glycerol-3-phosphate Acyltransferase Isoenzyme, mtGPAT2, in Mitochondria
    • DOI 10.1074/jbc.M314032200
    • T.M. Lewin, N.M. Schwerbrock, D.P. Lee, and R.A. Coleman Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria J. Biol. Chem. 279 2004 13488 13495 (Pubitemid 38468873)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.14 , pp. 13488-13495
    • Lewin, T.M.1    Schwerbrock, N.M.J.2    Lee, D.P.3    Coleman, R.A.4
  • 117
    • 0141644278 scopus 로고    scopus 로고
    • Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family
    • DOI 10.1007/s10038-003-0045-z
    • D. Li, L. Yu, H. Wu, Y. Shan, J. Guo, Y. Dang, Y. Wei, and S. Zhao Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family J. Hum. Genet. 48 2003 438 442 (Pubitemid 37221560)
    • (2003) Journal of Human Genetics , vol.48 , Issue.8 , pp. 438-442
    • Li, D.1    Yu, L.2    Wu, H.3    Shan, Y.4    Guo, J.5    Dang, Y.6    Wei, Y.7    Zhao, S.8
  • 118
    • 33745297834 scopus 로고    scopus 로고
    • Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module
    • DOI 10.2337/db05-0822
    • M.V. Li, B. Chang, M. Imamura, N. Poungvarin, and L. Chan Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module Diabetes 55 2006 1179 1189 (Pubitemid 44195353)
    • (2006) Diabetes , vol.55 , Issue.5 , pp. 1179-1189
    • Li, M.V.1    Chang, B.2    Imamura, M.3    Poungvarin, N.4    Chan, L.5
  • 120
    • 37249016419 scopus 로고    scopus 로고
    • Biosynthesis of the regulatory oxysterol, 5-cholesten-3β,25-diol 3-sulfate, in hepatocytes
    • DOI 10.1194/jlr.M700301-JLR200
    • X. Li, W.M. Pandak, S.K. Erickson, Y. Ma, L. Yin, P. Hylemon, and S. Ren Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta, 25-diol 3-sulfate, in hepatocytes J. Lipid Res. 48 2007 2587 2596 (Pubitemid 350272843)
    • (2007) Journal of Lipid Research , vol.48 , Issue.12 , pp. 2587-2596
    • Li, X.1    Pandak, W.M.2    Erickson, S.K.3    Ma, Y.4    Yin, L.5    Hylemon, P.6    Ren, S.7
  • 121
    • 34948883324 scopus 로고    scopus 로고
    • SIRT1 deacetylates and positively regulates the nuclear receptor LXR
    • DOI 10.1016/j.molcel.2007.07.032, PII S109727650700620X
    • X. Li, S. Zhang, G. Blander, J.G. Tse, M. Krieger, and L. Guarente SIRT1 deacetylates and positively regulates the nuclear receptor LXR Mol. Cell 28 2007 91 106 (Pubitemid 47531974)
    • (2007) Molecular Cell , vol.28 , Issue.1 , pp. 91-106
    • Li, X.1    Zhang, S.2    Blander, G.3    Tse, J.G.4    Krieger, M.5    Guarente, L.6
  • 122
    • 0037088683 scopus 로고    scopus 로고
    • Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
    • DOI 10.1074/jbc.M111421200
    • G. Liang, J. Yang, J.D. Horton, R.E. Hammer, J.L. Goldstein, and M.S. Brown Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c J. Biol. Chem. 277 2002 9520 9528 (Pubitemid 34953041)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.11 , pp. 9520-9528
    • Liang, G.1    Yang, J.2    Horton, J.D.3    Hammer, R.E.4    Goldstein, J.L.5    Brown, M.S.6
  • 124
    • 77957769750 scopus 로고    scopus 로고
    • FoxO1 represses LXRalpha-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells
    • X. Liu, A. Qiao, Y. Ke, X. Kong, J. Liang, R. Wang, X. Ouyang, J. Zuo, Y. Chang, and F. Fang FoxO1 represses LXRalpha-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells FEBS Lett. 584 2010 4330 4334
    • (2010) FEBS Lett. , vol.584 , pp. 4330-4334
    • Liu, X.1    Qiao, A.2    Ke, Y.3    Kong, X.4    Liang, J.5    Wang, R.6    Ouyang, X.7    Zuo, J.8    Chang, Y.9    Fang, F.10
  • 127
    • 78650520909 scopus 로고    scopus 로고
    • Lipoexpediency: De novo lipogenesis as a metabolic signal transmitter
    • I.J. Lodhi, X. Wei, and C.F. Semenkovich Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter Trends Endocrinol. Metab. 22 2011 1 8
    • (2011) Trends Endocrinol. Metab. , vol.22 , pp. 1-8
    • Lodhi, I.J.1    Wei, X.2    Semenkovich, C.F.3
  • 129
    • 12844249385 scopus 로고    scopus 로고
    • Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARα in murine heart
    • DOI 10.1042/BJ20041348
    • B. Lu, Y.J. Jiang, Y. Zhou, F.Y. Xu, G.M. Hatch, and P.C. Choy Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart Biochem. J. 385 2005 469 477 (Pubitemid 40165080)
    • (2005) Biochemical Journal , vol.385 , Issue.2 , pp. 469-477
    • Lu, B.1    Jiang, Y.J.2    Zhou, Y.3    Xu, F.Y.4    Hatch, G.M.5    Choy, P.C.6
  • 130
    • 33749407193 scopus 로고    scopus 로고
    • ChREBP·Mlx is the principal mediator of glucose-induced gene expression in the liver
    • DOI 10.1074/jbc.M601576200
    • L. Ma, L.N. Robinson, and H.C. Towle ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver J. Biol. Chem. 281 2006 28721 28730 (Pubitemid 44507014)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.39 , pp. 28721-28730
    • Ma, L.1    Robinson, L.N.2    Towle, H.C.3
  • 136
    • 0031043030 scopus 로고    scopus 로고
    • The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
    • J.D. McGarry, and N.F. Brown The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis Eur. J. Biochem. 244 1997 1 14 (Pubitemid 27079689)
    • (1997) European Journal of Biochemistry , vol.244 , Issue.1 , pp. 1-14
    • McGarry, J.D.1    Brown, N.F.2
  • 137
    • 0031568872 scopus 로고    scopus 로고
    • Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2)
    • DOI 10.1006/geno.1996.4525
    • A.R. Miserez, G. Cao, L.C. Probst, and H.H. Hobbs Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2) Genomics 40 1997 31 40 (Pubitemid 27108244)
    • (1997) Genomics , vol.40 , Issue.1 , pp. 31-40
    • Miserez, A.R.1    Cao, G.2    Probst, L.C.3    Hobbs, H.H.4
  • 138
    • 34247093820 scopus 로고    scopus 로고
    • T0901317 is a potent PXR ligand: Implications for the biology ascribed to LXR
    • DOI 10.1016/j.febslet.2007.03.047, PII S0014579307003195
    • N. Mitro, L. Vargas, R. Romeo, A. Koder, and E. Saez T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR FEBS Lett. 581 2007 1721 1726 (Pubitemid 46602262)
    • (2007) FEBS Letters , vol.581 , Issue.9 , pp. 1721-1726
    • Mitro, N.1    Vargas, L.2    Romeo, R.3    Koder, A.4    Saez, E.5
  • 139
    • 36448991861 scopus 로고    scopus 로고
    • Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis
    • DOI 10.1016/j.cmet.2007.10.014, PII S155041310700335X
    • M. Miyazaki, M.T. Flowers, H. Sampath, K. Chu, C. Otzelberger, X. Liu, and J.M. Ntambi Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis Cell Metab. 6 2007 484 496 (Pubitemid 350163054)
    • (2007) Cell Metabolism , vol.6 , Issue.6 , pp. 484-496
    • Miyazaki, M.1    Flowers, M.T.2    Sampath, H.3    Chu, K.4    Otzelberger, C.5    Liu, X.6    Ntambi, J.M.7
  • 140
    • 0141780830 scopus 로고    scopus 로고
    • Identification and Characterization of Murine SCD4, a Novel Heart-specific Stearoyl-CoA Desaturase Isoform Regulated by Leptin and Dietary Factors
    • DOI 10.1074/jbc.M304724200
    • M. Miyazaki, M.J. Jacobson, W.C. Man, P. Cohen, E. Asilmaz, J.M. Friedman, and J.M. Ntambi Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors J. Biol. Chem. 278 2003 33904 33911 (Pubitemid 37553224)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.36 , pp. 33904-33911
    • Miyazaki, M.1    Jacobson, M.J.2    Man, W.C.3    Cohen, P.4    Asilmaz, E.5    Friedman, J.M.6    Ntambi, J.M.7
  • 141
    • 64149083800 scopus 로고    scopus 로고
    • Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice
    • Y.A. Moon, R.E. Hammer, and J.D. Horton Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice J. Lipid Res. 50 2009 412 423
    • (2009) J. Lipid Res. , vol.50 , pp. 412-423
    • Moon, Y.A.1    Hammer, R.E.2    Horton, J.D.3
  • 142
    • 0035977004 scopus 로고    scopus 로고
    • Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins
    • Y.A. Moon, N.A. Shah, S. Mohapatra, J.A. Warrington, and J.D. Horton Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins J. Biol. Chem. 276 2001 45358 45366
    • (2001) J. Biol. Chem. , vol.276 , pp. 45358-45366
    • Moon, Y.A.1    Shah, N.A.2    Mohapatra, S.3    Warrington, J.A.4    Horton, J.D.5
  • 143
    • 0030615072 scopus 로고    scopus 로고
    • Ro 48-8071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: Comparison to simvastatin
    • O.H. Morand, J.D. Aebi, H. Dehmlow, Y.H. Ji, N. Gains, H. Lengsfeld, and J. Himber Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin J. Lipid Res. 38 1997 373 390 (Pubitemid 27118049)
    • (1997) Journal of Lipid Research , vol.38 , Issue.2 , pp. 373-390
    • Morand, O.H.1    Aebi, J.D.2    Dehmlow, H.3    Ji, Y.-H.4    Gains, N.5    Lengsfeld, H.6    Himber, J.7
  • 145
    • 44949176737 scopus 로고    scopus 로고
    • Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice
    • C.A. Nagle, L. Vergnes, H. Dejong, S. Wang, T.M. Lewin, K. Reue, and R.A. Coleman Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice J. Lipid Res. 49 2008 823 831
    • (2008) J. Lipid Res. , vol.49 , pp. 823-831
    • Nagle, C.A.1    Vergnes, L.2    Dejong, H.3    Wang, S.4    Lewin, T.M.5    Reue, K.6    Coleman, R.A.7
  • 146
    • 0019420840 scopus 로고
    • Biosynthesis of 24,25-epoxycholesterol from squalene 2,3;22,23-dioxide
    • J.A. Nelson, S.R. Steckbeck, and T.A. Spencer Biosynthesis of 24,25-epoxycholesterol from squalene 2,3;22,23-dioxide J. Biol. Chem. 256 1981 1067 1068 (Pubitemid 11157204)
    • (1981) Journal of Biological Chemistry , vol.256 , Issue.3 , pp. 1067-1068
    • Nelson, J.A.1    Steckbeck, S.R.2    Spencer, T.A.3
  • 148
    • 0032871502 scopus 로고    scopus 로고
    • Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol
    • J.M. Ntambi Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol J. Lipid Res. 40 1999 1549 1558 (Pubitemid 29418696)
    • (1999) Journal of Lipid Research , vol.40 , Issue.9 , pp. 1549-1558
    • Ntambi, J.M.1
  • 149
    • 0024297268 scopus 로고
    • Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase
    • J.M. Ntambi, S.A. Buhrow, K.H. Kaestner, R.J. Christy, E. Sibley, T.J. Kelly Jr., and M.D. Lane Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase J. Biol. Chem. 263 1988 17291 17300
    • (1988) J. Biol. Chem. , vol.263 , pp. 17291-17300
    • Ntambi, J.M.1    Buhrow, S.A.2    Kaestner, K.H.3    Christy, R.J.4    Sibley, E.5    Kelly, Jr.T.J.6    Lane, M.D.7
  • 151
    • 0035844297 scopus 로고    scopus 로고
    • Glucose regulation of the acetyl-CoA carboxylase promoter PI in rat hepatocytes
    • B.L. O'Callaghan, S.H. Koo, Y. Wu, H.C. Freake, and H.C. Towle Glucose regulation of the acetyl-CoA carboxylase promoter PI in rat hepatocytes J. Biol. Chem. 276 2001 16033 16039
    • (2001) J. Biol. Chem. , vol.276 , pp. 16033-16039
    • O'Callaghan, B.L.1    Koo, S.H.2    Wu, Y.3    Freake, H.C.4    Towle, H.C.5
  • 152
    • 0032500641 scopus 로고    scopus 로고
    • Characterization of two human genes encoding acyl coenzyme A: Cholesterol acyltransferase-related enzymes
    • DOI 10.1074/jbc.273.41.26765
    • P. Oelkers, A. Behari, D. Cromley, J.T. Billheimer, and S.L. Sturley Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes J. Biol. Chem. 273 1998 26765 26771 (Pubitemid 28471693)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.41 , pp. 26765-26771
    • Oelkers, P.1    Behari, A.2    Cromley, D.3    Billheimer, J.T.4    Sturleyt, S.L.5
  • 154
    • 79953737607 scopus 로고    scopus 로고
    • MicroRNA hsa-miR-613 targets the human LXR{alpha} gene and mediates a feedback loop of LXR{alpha} autoregulation
    • Z. Ou, T. Wada, R. Gramignoli, S. Li, S.C. Strom, M. Huang, and W. Xie MicroRNA hsa-miR-613 targets the human LXR{alpha} gene and mediates a feedback loop of LXR{alpha} autoregulation Mol. Endocrinol. 25 2011 584 596
    • (2011) Mol. Endocrinol. , vol.25 , pp. 584-596
    • Ou, Z.1    Wada, T.2    Gramignoli, R.3    Li, S.4    Strom, S.C.5    Huang, M.6    Xie, W.7
  • 155
    • 0022905095 scopus 로고
    • Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols
    • S.R. Panini, R.C. Sexton, A.K. Gupta, E.J. Parish, S. Chitrakorn, and H. Rudney Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols J. Lipid Res. 27 1986 1190 1204 (Pubitemid 17233750)
    • (1986) Journal of Lipid Research , vol.27 , Issue.11 , pp. 1190-1204
    • Panini, S.R.1    Sexton, R.C.2    Gupta, A.K.3
  • 156
    • 0142103471 scopus 로고    scopus 로고
    • The role of liver X receptor-α in the fatty acid regulation of hepatic gene expression
    • DOI 10.1074/jbc.M307973200
    • A. Pawar, D. Botolin, D.J. Mangelsdorf, and D.B. Jump The role of liver X receptor-α in the fatty acid regulation of hepatic gene expression J. Biol. Chem. 278 2003 40736 40743 (Pubitemid 37280889)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.42 , pp. 40736-40743
    • Pawar, A.1    Botolin, D.2    Mangelsdorf, D.J.3    Jump, D.B.4
  • 157
    • 0037131234 scopus 로고    scopus 로고
    • Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor α (PPARα) in HEK293 cells
    • DOI 10.1074/jbc.M206170200
    • A. Pawar, J. Xu, E. Jerks, D.J. Mangelsdorf, and D.B. Jump Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha) in HEK293 cells J. Biol. Chem. 277 2002 39243 39250 (Pubitemid 35190894)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.42 , pp. 39243-39250
    • Pawar, A.1    Xu, J.2    Jerks, E.3    Mangelsdorf, D.J.4    Jump, D.B.5
  • 158
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
    • DOI 10.1016/S0092-8674(00)81432-4
    • D.J. Peet, S.D. Turley, W. Ma, B.A. Janowski, J.M. Lobaccaro, R.E. Hammer, and D.J. Mangelsdorf Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha Cell 93 1998 693 704 (Pubitemid 28257577)
    • (1998) Cell , vol.93 , Issue.5 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.-M.A.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 161
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice
    • DOI 10.1172/JCI34275
    • C. Postic, and J. Girard Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice J. Clin. Invest. 118 2008 829 838 (Pubitemid 351364588)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.3 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 163
    • 0034518420 scopus 로고    scopus 로고
    • The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
    • DOI 10.1146/annurev.cellbio.16.1.459
    • J.J. Repa, and D.J. Mangelsdorf The role of orphan nuclear receptors in the regulation of cholesterol homeostasis Annu. Rev. Cell Dev. Biol. 16 2000 459 481 (Pubitemid 32037514)
    • (2000) Annual Review of Cell and Developmental Biology , vol.16 , pp. 459-481
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 166
    • 0035877604 scopus 로고    scopus 로고
    • Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription
    • C. Rufo, M. Teran-Garcia, M.T. Nakamura, S.H. Koo, H.C. Towle, and S.D. Clarke Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription J. Biol. Chem. 276 2001 21969 21975
    • (2001) J. Biol. Chem. , vol.276 , pp. 21969-21975
    • Rufo, C.1    Teran-Garcia, M.2    Nakamura, M.T.3    Koo, S.H.4    Towle, H.C.5    Clarke, S.D.6
  • 167
    • 0034672672 scopus 로고    scopus 로고
    • Oxysterol biosynthetic enzymes
    • D.W. Russell Oxysterol biosynthetic enzymes Biochim. Biophys. Acta 1529 2000 126 135
    • (2000) Biochim. Biophys. Acta , vol.1529 , pp. 126-135
    • Russell, D.W.1
  • 169
    • 0022341712 scopus 로고
    • Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts
    • S.E. Saucier, A.A. Kandutsch, F.R. Taylor, T.A. Spencer, S. Phirwa, and A.K. Gayen Identification of regulatory oxysterols, 24(S), 25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts J. Biol. Chem. 260 1985 14571 14579 (Pubitemid 16210980)
    • (1985) Journal of Biological Chemistry , vol.260 , Issue.27 , pp. 14571-14579
    • Saucier, S.E.1    Kandutsch, A.A.2    Taylor, F.R.3
  • 170
    • 0342316532 scopus 로고    scopus 로고
    • Oxysterols: Modulators of cholesterol metabolism and other processes
    • G.J. Schroepfer Jr. Oxysterols: modulators of cholesterol metabolism and other processes Physiol. Rev. 80 2000 361 554 (Pubitemid 30060568)
    • (2000) Physiological Reviews , vol.80 , Issue.1 , pp. 361-554
    • Schroepfer Jr., G.J.1    Wilson, W.K.2
  • 174
    • 77954956306 scopus 로고    scopus 로고
    • Lipidomics: Coming to grips with lipid diversity
    • A. Shevchenko, and K. Simons Lipidomics: coming to grips with lipid diversity Nat. Rev. Mol. Cell Biol. 11 2010 593 598
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 593-598
    • Shevchenko, A.1    Simons, K.2
  • 175
    • 0030907175 scopus 로고    scopus 로고
    • Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
    • H. Shimano, J.D. Horton, I. Shimomura, R.E. Hammer, M.S. Brown, and J.L. Goldstein Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells J. Clin. Invest. 99 1997 846 854 (Pubitemid 27123620)
    • (1997) Journal of Clinical Investigation , vol.99 , Issue.5 , pp. 846-854
    • Shimano, H.1    Horton, J.D.2    Shimomura, I.3    Hammer, R.E.4    Brown, M.S.5    Goldstein, J.L.6
  • 177
    • 0030961960 scopus 로고    scopus 로고
    • Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
    • I. Shimomura, H. Shimano, J.D. Horton, J.L. Goldstein, and M.S. Brown Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells J. Clin. Invest. 99 1997 838 845 (Pubitemid 27123619)
    • (1997) Journal of Clinical Investigation , vol.99 , Issue.5 , pp. 838-845
    • Shimomura, I.1    Shimano, H.2    Horton, J.D.3    Goldstein, J.L.4    Brown, M.S.5
  • 178
    • 0023243055 scopus 로고
    • Cholesterol autoxidation 1981-1986
    • L.L. Smith Cholesterol autoxidation 1981-1986 Chem. Phys. Lipids 44 1987 87 125 (Pubitemid 17146543)
    • (1987) Chemistry and Physics of Lipids , vol.44 , Issue.2-4 , pp. 87-125
    • Smith, L.L.1
  • 179
    • 0028557012 scopus 로고
    • The animal fatty acid synthase: One gene, one polypeptide, seven enzymes
    • S. Smith The animal fatty acid synthase: one gene, one polypeptide, seven enzymes FASEB J. 8 1994 1248 1259
    • (1994) FASEB J. , vol.8 , pp. 1248-1259
    • Smith, S.1
  • 181
    • 3142654791 scopus 로고    scopus 로고
    • Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase
    • B.L. Song, and R.A. DeBose-Boyd Ubiquitination of 3-hydroxy-3- methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase J. Biol. Chem. 279 2004 28798 28806
    • (2004) J. Biol. Chem. , vol.279 , pp. 28798-28806
    • Song, B.L.1    Debose-Boyd, R.A.2
  • 182
    • 0035372651 scopus 로고    scopus 로고
    • Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: Implications for the development and treatment of atherosclerosis
    • DOI 10.1016/S0039-128X(00)00239-7, PII S0039128X00002397
    • C. Song, R.A. Hiipakka, and S. Liao Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis Steroids 66 2001 473 479 (Pubitemid 32140924)
    • (2001) Steroids , vol.66 , Issue.6 , pp. 473-479
    • Song, C.1    Hiipakka, R.A.2    Liao, S.3
  • 183
    • 0036135597 scopus 로고    scopus 로고
    • Synthesis of triacylglycerols by the acyl-coenzyme A:diacyl-glycerol acyltransferase Dga1p in lipid particles of the yeast Saccharomyces cerevisiae
    • D. Sorger, and G. Daum Synthesis of triacylglycerols by the acyl-coenzyme A:diacyl-glycerol acyltransferase Dga1p in lipid particles of the yeast Saccharomyces cerevisiae J. Bacteriol. 184 2002 519 524 (Pubitemid 34027393)
    • (2002) Journal of Bacteriology , vol.184 , Issue.2 , pp. 519-524
    • Sorger, D.1    Daum, G.2
  • 185
    • 2442614148 scopus 로고    scopus 로고
    • Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes
    • DOI 10.1074/jbc.M311301200
    • A.K. Stoeckman, L. Ma, and H.C. Towle Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes J. Biol. Chem. 279 2004 15662 15669 (Pubitemid 38618968)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.15 , pp. 15662-15669
    • Stoeckman, A.K.1    Ma, L.2    Towle, H.C.3
  • 186
    • 64149132208 scopus 로고    scopus 로고
    • The endoplasmic reticulum enzyme DGAT2 is found in mitochondria- associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria
    • S.J. Stone, M.C. Levin, P. Zhou, J. Han, T.C. Walther, and R.V. Farese Jr. The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria J. Biol. Chem. 284 2009 5352 5361
    • (2009) J. Biol. Chem. , vol.284 , pp. 5352-5361
    • Stone, S.J.1    Levin, M.C.2    Zhou, P.3    Han, J.4    Walther, T.C.5    Farese, Jr.R.V.6
  • 189
    • 67649421649 scopus 로고    scopus 로고
    • Functional characterization of the human 1-acylglycerol-3-phosphate-O- acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3
    • S. Sukumaran, R.I. Barnes, A. Garg, and A.K. Agarwal Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3 J. Mol. Endocrinol. 42 2009 469 478
    • (2009) J. Mol. Endocrinol. , vol.42 , pp. 469-478
    • Sukumaran, S.1    Barnes, R.I.2    Garg, A.3    Agarwal, A.K.4
  • 191
    • 0040799893 scopus 로고    scopus 로고
    • Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2
    • D.E. Tabor, J.B. Kim, B.M. Spiegelman, and P.A. Edwards Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2 J. Biol. Chem. 274 1999 20603 20610
    • (1999) J. Biol. Chem. , vol.274 , pp. 20603-20610
    • Tabor, D.E.1    Kim, J.B.2    Spiegelman, B.M.3    Edwards, P.A.4
  • 193
    • 33845586243 scopus 로고    scopus 로고
    • The mechanism mediating the activation of acetyl-coenzyme A carboxylase-α gene transcription by the liver X receptor agonist T0-901317
    • DOI 10.1194/jlr.M600276-JLR200
    • S. Talukdar, and F.B. Hillgartner The mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317 J. Lipid Res. 47 2006 2451 2461 (Pubitemid 44936107)
    • (2006) Journal of Lipid Research , vol.47 , Issue.11 , pp. 2451-2461
    • Talukdar, S.1    Hillgartner, F.B.2
  • 195
    • 0023000290 scopus 로고
    • 24,25-epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase
    • F.R. Taylor, A.A. Kandutsch, A.K. Gayen, J.A. Nelson, S.S. Nelson, S. Phirwa, and T.A. Spencer 24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase J. Biol. Chem. 261 1986 15039 15044 (Pubitemid 17218070)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.32 , pp. 15039-15044
    • Taylor, F.R.1    Kandutsch, A.A.2    Gayen, A.K.3
  • 203
    • 0028225462 scopus 로고
    • SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
    • X. Wang, R. Sato, M.S. Brown, X. Hua, and J.L. Goldstein SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis Cell 77 1994 53 62
    • (1994) Cell , vol.77 , pp. 53-62
    • Wang, X.1    Sato, R.2    Brown, M.S.3    Hua, X.4    Goldstein, J.L.5
  • 205
    • 10644229420 scopus 로고    scopus 로고
    • Statins inhibit synthesis of an oxysterol ligand for the liver X receptor in human macrophages with consequences for cholesterol flux
    • DOI 10.1161/01.ATV.0000148707.93054.7d
    • J. Wong, C.M. Quinn, and A.J. Brown Statins inhibit synthesis of an oxysterol ligand for the liver X receptor in human macrophages with consequences for cholesterol flux Arterioscler. Thromb. Vasc. Biol. 24 2004 2365 2371 (Pubitemid 39658043)
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , Issue.12 , pp. 2365-2371
    • Wong, J.1    Quinn, C.M.2    Brown, A.J.3
  • 206
    • 33845748205 scopus 로고    scopus 로고
    • SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR
    • DOI 10.1042/BJ20060914
    • J. Wong, C.M. Quinn, and A.J. Brown SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR Biochem. J. 400 2006 485 491 (Pubitemid 44974460)
    • (2006) Biochemical Journal , vol.400 , Issue.3 , pp. 485-491
    • Wong, J.1    Quinn, C.M.2    Brown, A.J.3
  • 207
    • 34247381583 scopus 로고    scopus 로고
    • Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol
    • J. Wong, C.M. Quinn, and A.J. Brown Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol Lipids Health Dis. 6 2007 10
    • (2007) Lipids Health Dis. , vol.6 , pp. 10
    • Wong, J.1    Quinn, C.M.2    Brown, A.J.3
  • 208
    • 38149138153 scopus 로고    scopus 로고
    • Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis
    • J. Wong, C.M. Quinn, I.C. Gelissen, and A.J. Brown Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis J. Biol. Chem. 283 2008 700 707
    • (2008) J. Biol. Chem. , vol.283 , pp. 700-707
    • Wong, J.1    Quinn, C.M.2    Gelissen, I.C.3    Brown, A.J.4
  • 209
    • 38049081038 scopus 로고    scopus 로고
    • The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation
    • J. Wong, C.M. Quinn, I.C. Gelissen, W. Jessup, and A.J. Brown The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation Atherosclerosis 196 2008 180 189
    • (2008) Atherosclerosis , vol.196 , pp. 180-189
    • Wong, J.1    Quinn, C.M.2    Gelissen, I.C.3    Jessup, W.4    Brown, A.J.5
  • 211
    • 77957558615 scopus 로고    scopus 로고
    • Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate
    • L. Xu, Q. Bai, D. Rodriguez-Agudo, P.B. Hylemon, D.M. Heuman, W.M. Pandak, and S. Ren Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate Lipids 45 2010 821 832
    • (2010) Lipids , vol.45 , pp. 821-832
    • Xu, L.1    Bai, Q.2    Rodriguez-Agudo, D.3    Hylemon, P.B.4    Heuman, D.M.5    Pandak, W.M.6    Ren, S.7
  • 217
    • 0027490174 scopus 로고
    • SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
    • DOI 10.1016/0092-8674(93)90690-R
    • C. Yokoyama, X. Wang, M.R. Briggs, A. Admon, J. Wu, X. Hua, J.L. Goldstein, and M.S. Brown SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene Cell 75 1993 187 197 (Pubitemid 23306032)
    • (1993) Cell , vol.75 , Issue.1 , pp. 187-197
    • Yokoyama, C.1    Wang, X.2    Briggs, M.R.3    Admon, A.4    Wu, J.5    Hua, X.6    Goldstein, J.L.7    Brown, M.S.8
  • 219
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • DOI 10.1172/JCI27883
    • N. Zelcer, and P. Tontonoz Liver X receptors as integrators of metabolic and inflammatory signaling J. Clin. Invest. 116 2006 607 614 (Pubitemid 43326865)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 221
    • 0035862555 scopus 로고    scopus 로고
    • Scd3 - A novel gene of the stearoyl-CoA desaturase family with restricted expression in skin
    • DOI 10.1006/geno.2000.6429
    • Y. Zheng, S.M. Prouty, A. Harmon, J.P. Sundberg, K.S. Stenn, and S. Parimoo Scd3-a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin Genomics 71 2001 182 191 (Pubitemid 32165085)
    • (2001) Genomics , vol.71 , Issue.2 , pp. 182-191
    • Zheng, Y.1    Prouty, S.M.2    Harmon, A.3    Sundberg, J.P.4    Stenn, K.S.5    Parimoo, S.6


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