Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

Journal of Clinical Investigation

Volumn 99, Issue 5, 1997, Pages 846-854

  Shimano, Hitoshi ^a   Horton, Jay D ^a   Shimomura, Iichiro ^a   Hammer, Robert E ^a,b   Brown, Michael S ^a   Goldstein, Joseph L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

alternative splicing; cholesterol; fatty acids; SREBP 1; transgenic mice

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CHOLESTEROL; FATTY ACID SYNTHASE; LOW DENSITY LIPOPROTEIN RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEPATOMEGALY; HUMAN; HUMAN CELL; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0030907175     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119248     Document Type: Article

References (33)

1. Wang, X., R. Sato, M.S. Brown, X. Hua, and J.L. Goldstein. 1994. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell. 77:53-62.
2. Shimano, H., J.D. Horton, R.E. Hammer, I. Shimomura, M.S. Brown, and J.L. Goldstein. 1996. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J. Clin. Invest. 98:1575-1584.
3. Kim, J.B., and B.M. Spiegelman. 1996. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev. 10:1096-1107.
4. Ericsson, J., S.M. Jackson, B.C. Lee, and P.A. Edwards. 1996. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene. Proc. Natl. Acad. Sci. USA. 93:945-950.
5. Bennett, M.K., J.M. Lopez, H.B. Sanchez, and T.F. Osborne. 1995. Sterol regulation of fatty acid synthase promoter: coordinate feedback regulation of two major lipid pathways. J. Biol. Chem. 270:25578-25583.
6. Yokoyama, C., X. Wang, M.R. Briggs, A. Admon, J. Wu, X. Hua, J.L. Goldstein, and M.S. Brown. 1993. SREBP-1, a basic helix-loop-helix leucine zipper protein that controls transcription of the LDL receptor gene. Cell. 75: 187-197.
7. Hua, X., J. Wu, J.L. Goldstein, M.S. Brown, and H.H. Hobbs. 1995. Structure of human gene encoding sterol regulatory element binding protein-1 (SRERF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. Genomics. 25:667-673.
8. Shimomura, I., H. Shimano, J.D. Horton, J.L. Goldstein, and M.S. Brown. 1997. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J. Clin. Invest. 99:838-845.
9. Hua, X., C. Yokoyama, J. Wu, M.R. Briggs, M.S. Brown, J.L. Goldstein, and X. Wang. 1993. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. Natl. Acad. Sci. USA. 90:11603-11607.
10. Sato, R., J. Yang, X. Wang, M.J. Evans, Y.K. Ho, J.L. Goldstein, and M.S. Brown. 1994. Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element binding protein-1 (SREBP-1). J. Biol. Chem. 269:17267-17273.
11. Yang, J., R. Sato, J.L. Goldstein, and M.S. Brown. 1994. Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2. Genes Dev. 8:1910-1919.
12. Hua, X., J. Sakai, Y.K. Ho, J.L. Goldstein, and M.S. Brown. 1995. Hairpin orientation of sterol regulatory element binding protein-2 in cell membranes as determined by protease protection. J. Biol. Chem. 270:29422-29427.
13. Hua, X., J. Sakai, M.S. Brown, and J.L. Goldstein. 1996. Regulated cleavage of sterol regulatory element binding proteins (SREBPs) requires sequences on both sides of the endoplasmic reticulum membrane. J. Biol. Chem. 271:10379-10384.
14. Sakai, J., E.A. Duncan, R.B. Rawson, X. Hua, M.S. Brown, and J.L. Goldstein. 1996. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell. 85: 1037-1046.
15. Guan, G., G. Jiang, R.L. Koch, and I. Shechter. 1995. Molecular cloning and functional analysis of the promoter of the human squalene synthase gene. J. Biol. Chem. 270:21958-21965.
16. Yieh, L., H.B. Sanchez, and T.F. Osborne. 1995. Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoter. Proc. Natl. Acad. Sci. USA. 92:6102-6106.
17. Briggs, M.R., C. Yokoyama, X. Wang, M.S. Brown, and J.L. Goldstein. 1993. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter I. Identification of the protein and delineation of its target nucleotide sequence. J. Biol. Chem. 268:14490-14496.
18. Ericsson, J., S.M. Jackson, and P.A. Edwards. 1996. Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene. J. Biol. Chem. 271:24359-24364.
19. Tontonoz, P., J.B. Kim, R.A. Graves, and B.M. Spiegelman. 1993. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell. Biol. 13:4753-4759.
20. Vallett, S.M., H.B. Sanchez, J.M. Rosenfeld, and T.F. Osborne. 1996. A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. J. Biol. Chem. 271:12247-12253.
21. Kim, J.B., G.D. Spotts, Y.-D. Halvorsen, H.-M. Shih, T. Ellenberger, H.C. Towle, and B.M. Spiegelman. 1995. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol. Cell. Biol. 15:2582-2588.
22. Yang, J., M.S. Brown, Y.K. Ho, and J.L. Goldstein. 1995. Three different rearrangements in a single intron truncate SREBP-2 and produce sterol-resistant phenotype in three cell lines. J. Biol. Chem. 270:12152-12161.
23. Sheng, Z., H. Otani, M.S. Brown, and J.L. Goldstein. 1995. Independent regulation of sterol regulatory element binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA. 92:935-938.
24. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, New York.
25. Hua, X., A. Nohturfft, J.L. Goldstein, and M.S. Brown. 1996. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage activating protein (SCAP). Cell. 87:415-426.
26. Smith, J.R., T.F. Osborne, M.S. Brown, J.L. Goldstein, and G. Gil. 1988. Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl coenzyme A synthase. J. Biol. Chem. 263:18480-18487.
27. Südhof, T.C., D.W. Russell, M.S. Brown, and J.L. Goldstein. 1987. 42-bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter. Cell. 48:1061-1069.
28. Andersson, S., D.L. Davis, H. Dahlback, H. Jornvall, and D.W. Russell. 1989. Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J. Biol. Chem. 264:8222-8229.
29. Amy, C.M., B. Williams-Ahlf, J. Naggert, and S. Smith. 1990. Molecular cloning of the mammalian fatty acid synthase gene and identification of the promoter region. Biochem. J. 271:675-679.
30. Chang, S.-F., H.J. Netter, and H. Will. 1991. Characterization of cDNA encoding the mouse hepatic triglyceride lipase and expression by in vitro translation. FEBS Lett. 289:69-72.
31. Smith, J.R., T.F. Osborne, J.L. Goldstein, and M.S. Brown. 1990. Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene. J. Biol. Chem. 265:2306-2310.
32. Ohner, J.D., J.M. Andresen, S.K. Hansen, S. Zhou, and R. Tjian. 1996. SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. Genes Dev. 10:2903-2911.
33. Ayer, D.E., L. Kretzner, and R.N. Eisenman. 1993. Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell. 72:211-222.