Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 11, 2003, Pages 6358-6363

  Chirala, Subrahmanyam S ^a   Chang, Hua ^a   Matzuk, Martin ^a   Abu Elheiga, Lutfi ^a   Mao, Jianqiang ^a   Mahon, Kathleen ^a   Finegold, Milton ^a   Wakil, Salih J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID SYNTHASE; LONG CHAIN FATTY ACID; MESSENGER RNA; MUTANT PROTEIN; SATURATED FATTY ACID;

ANIMAL EXPERIMENT; ARTICLE; BREEDING; CANCER GROWTH; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; FATTY ACID SYNTHESIS; FEMALE; FETUS DEATH; GENE DOSAGE; HETEROZYGOTE; HOMOZYGOTE; INHERITANCE; KNOCKOUT MOUSE; MALE; MOUSE; NIDATION; NONHUMAN; NULL ALLELE; OBESITY; PRIORITY JOURNAL; PROGENY; TERATOGENESIS;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HETEROZYGOTE; MALE; MICE; MICE, KNOCKOUT;

ANIMALIA; HOMO; MAMMALIA;

EID: 0037637624     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0931394100     Document Type: Article

References (20)

1. Wakil, S. J. (1989) Biochemistry 28, 4523-4530.
2. Smith, S. (1994) FASEB J. 8, 1248-1259.
3. Stoops, J. K. & Wakil, S. J. (1981) J. Biol. Chem. 256, 5128-5133.
4. Chirala, S. S., Jayakumar, A., Gu, Z.-W. & Wakil, S. J. (2001) Proc. Natl. Acad. Sci. USA 98, 3104-3108.
5. Jayakumar, A., Tai, M.-H., Huang, W.-Y., Al-Feel, W., Hsu, M., Abu-Elheiga, L., Chiral, S. S. & Wakil, S. J. (1995) Proc. Natl. Acad. Sci. USA 92, 8695-8699.
6. Hannun, Y. A. & Obeid, L. M. (2002) J. Biol. Chem. 277, 25847-23850.
7. Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D. & Pasternack, G. R. (1994) Proc. Natl. Acad. Sci. USA 91, 6379-6383.
8. Loftus, T. M., Jaworsky, D. E., Frehywot, G. L., Towsand, C. A., Ronnett, G. V., Lane, M. D. & Kuhajda, F. P. (2000) Science 288, 2379-2381.
9. Pizer, E. S., Thupari, J., Han, W. F., Pinn, M. L., Cherst, F. J., Frehywot, G. L., Townsend, C. A. & Kuhajda, F. P. (2000) Cancer Res. 60, 213-238.
10. Paulakis, J. D. & Sul, H. S. (1989) Biochem. Biophys. Res. Commun. 158, 690-695.
11. Amy, C. M., Williams-Ahlf, B., Naggert, J. & Smith, S. (1992) Proc. Natl. Acad. Sci. USA. 89, 1105-1108.
12. Beck, K. F., Schreglmann, R., Stathopulos, I., Klein, H., Hoch, J. & Schweizer, M. (1992) DNA Seq. 2, 359-386.
13. Chirala, S. S., Huang, W.-Y., Jayakumar, A., Sakai, K. & Wakil, S. J. (1997) Proc. Natl. Acad. Sci. USA 94, 5588-5593.
14. Bradley, A. (1987) in Production and Analysis of Chimeric Mice, ed. Robinson, E. J. (IRL, Oxford), pp. 113-151.
15. Chang, H., Huylebroeck, D., Verschueren, K., Guo, Q., Matzuk, M. M. & Zwijsen, A. (1999) Development (Cambridge, U.K.) 126, 1631-1642.
16. Matzuk, M. M., Finegold, M. J., Su, J. G., Hsueh, A. J. & Bradley, A. (1992) Nature 360, 313-319.
17. Maniatis, T., Fritsch, E. F. & Sambrook, J. (1982) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
18. Conlon, R. A. & Rossant, J. (1992) Development (Cambridge, U.K.) 116, 357-368.
19. Hirsch, J. (1965) in Handbook of Physiology, eds. Renold, A. E. & Cahill, G. F., Jr. (Am. Physiol. Soc., Washington, DC), pp. 181-189.
20. Hirsch, J. (2002) Proc. Natl. Acad. Sci. USA 99, 9096-9097.