SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR

Biochemical Journal

Volumn 400, Issue 3, 2006, Pages 485-491

  Wong, Jenny ^a   Quinn, Carmel M ^a,b   Brown, Andrew J ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

24(S),25 epoxycholesterol; ATP binding cassette transporter A1 (ABCA1); E box; Liver x receptor (LXR); Statin; Sterol regulatory element binding protein 2 (SREBP 2)

Indexed keywords

BIOASSAY; BIOCHEMISTRY; BIOSYNTHESIS; CHOLESTEROL; PROTEINS;

24(S),25- EPOXYCHOLESTEROL; ATP-BINDING-CASSETTE TRANSPORTER-A1 (ABCA1); E-BOX; LIVER X RECEPTOR (LXR); STATIN TREATMENT; STEROL-REGULATORY-ELEMENT-BINDING PROTEIN 2 (SREBP-2);

GENES;

ABC TRANSPORTER A1; LIVER X RECEPTOR; MESSENGER RNA; OXYSTEROL; STATIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ANIMAL CELL; ARTICLE; CHO CELL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; E BOX ELEMENT; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR BINDING; TRANSCRIPTION REGULATION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CHOLESTEROL; CRICETINAE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; LIGANDS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION, GENETIC; UP-REGULATION;

CRICETINAE;

EID: 33845748205     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060914     Document Type: Article

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