The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

Annual Review of Cell and Developmental Biology

Volumn 16, Issue , 2000, Pages 459-481

  Repa, J J ^a   Mangelsdorf, D J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Bile acids; FXR; LXR; Oxysterols; RXR

Indexed keywords

BILE ACID; CELL NUCLEUS RECEPTOR; CHOLESTEROL; FARNESOID X RECEPTOR; LIVER RECEPTOR HOMOLOG 1; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; ORPHAN NUCLEAR RECEPTOR; RETINOID X RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

BILE ACID METABOLISM; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; HOMEOSTASIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW;

ANIMALS; CHOLESTEROL; HOMEOSTASIS; HUMANS; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 0034518420     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.16.1.459     Document Type: Review

References (129)

1. Partial transfection of liver with a synthetic cholesterol 7α-hydroxylase transgene is sufficient to stimulate the reduction of cholesterol in the plasma of hypercholesterolemic mice
2. Correlation of bile acid composition between liver tissue and bile
3. Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme
4. A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily
5. Potential bile acid precursors in plasma - Possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man
6. Bile acid transport
7. Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences
8. Regulation of bile acid synthesis in humans: Studies on cholesterol 7α-hydroxylation in vivo
9. Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry
10. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membranebound transcription factor
11. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
12. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis
13. Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reactions in bile acid biosynthesis
14. Genetic variation in cholesterol absorption efficiency among inbred strains of mice
15. Hepatocyte nuclear factor 1 binds to and transactivates the human but not the rat CYP7A1 promoter
16. Regulation of bile acid synthesis
17. Identification and characterization of a putative bile acid-responsive element in cholesterol 7α-hydroxylase gene promoter
18. Generating and characterizing retinoid receptors from Escherichia coli and insect cell expression systems
19. Sterol metabolism studies in the rat. Effects of primary bile acids (sodium taurochenodeoxycholate and sodium taurocholate) on sterol metabolism
20. Cloning of the human cholesterol 7α-hydroxylase gene (CYP7) and localization to chromosome q11-q12
21. Genomic cloning, sequencing, and analysis of the hamster cholesterol 7α-hydroxylase gene (CYP7)
22. The mouse ileal lipid-binding protein gene: A model for studying axial patterning during gut morphogenesis
23. Bile acid transporters
24. Intestinal cholesterol absorption
25. Biosynthesis of cholest-5-ene-3β, 24-diol (cerebrosterol) by bovine cerebral cortical microsomes
26. The isolation of crystalline 22R-hydroxycholesterol and 20α,22R-dihydroxycholesterol from bovine adrenals
27. Molecular cloning and expression of rabbit sterol 12α-hydroxylase
28. FTZ-F1-related orphan receptors in Xenopus laevis: Transcriptional regulators differentially expressed during early embryogenesis
29. Identification of a nuclear receptor that is activated by farnesol metabolites
30. Structure and chromosomal assignment of the sterol 12αhydroxylase gene (CYP8B1) in human and mouse: Eukaryotic cytochrome P-450 gene devoid of introns
31. The α-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 family
32. Rat-liver cholesterol 7α-hydroxylase. 3. New results about its circadian rhythm
33. Orphan nuclear receptors: From gene to function
34. The coregulator exchange in transcriptional functions of nuclear receptors
35. Identification of a bile acidresponsive element in the human ileal bile acid-binding protein gene
36. Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apoE phenotypes
37. Regulation of serum cholesterol level in middle-aged and elderly men
38. Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat
39. 9-Cis retinoic acid is a high affinity ligand for the retinoid X receptor
40. Established and emerging strategies for inhibition of cholesterol absorption
41. Regulation of hepatic 7α-hydroxylase expression and response to dietary cholesterol in the rat and hamster
42. Sterol regulatory element-binding proteins: Activators of cholesterol and fatty acid biosynthesis
43. Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ
44. An oxysterol signalling pathway mediated by the nuclear receptor LXRα
45. Cloning and regulation of cholesterol 7α-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis
46. Genetic differences in cholesterol absorption in 129/Sv and C57BL/6 mice: Effect on cholesterol responsiveness
47. Regulation of expression of human intestinal bile acid-binding protein in Caco-2 cells
48. Effect of bile on the intestinal bile-acid binding protein (I-BABP) expression. In vitro and in vivo studies
49. Cholesterol absorption efficiency regulates plasma cholesterol level in the Finnish population
50. Hyper- and hyporesponsiveness to dietary fat and cholesterol among inbred mice: Searching for level and variability genes
51. Orphan nuclear receptors: Shifting endocrinology into reverse
52. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
53. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
54. Molecular cloning of chicken FTZ-F1-related orphan receptors
55. Circadian transcription of the cholesterol 7α hydroxylase gene may involve the liver-enriched bZIP protein DBP
56. Bile acid synthesis in man. II. Determination of 7α-hydroxycholesterol, (22R)-22-hydroxycholesterol, and 26-hydroxycholesterol in human meconium
57. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
58. Regulation of cholesterol 7α-hydroxylase in the liver
59. Sterol metabolism, XXVIII. Biosynthesis and accumulation of cholest-5-ene-3β,24-diol (cerebrosterol) in developing rat brain
60. Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
61. Identification of a nuclear receptor for bile acids
62. Patterns of bile acids and microflora in the human small intestine
63. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid
64. The RXR heterodimers and orphan receptors
65. The nuclear receptor superfamily: The second decade
66. Cholesterol 7α-hydroxylase (CYP7A): Patterns of messenger RNA expression during rat liver development
67. Nuclear receptor coregulators: Cellular and molecular biology
68. Cholesterol absorption: Regulation of cholesterol synthesis and elimination and within-population variations of serum cholesterol levels
69. Transcriptional regulation of the human cholesterol 7α-hydroxylase gene
70. Comparative regulation of hepatic sterol 27-hydroxylase and cholesterol 7α-hydroxylase activities in the rat, guinea pig, and rabbit: Effects of cholesterol and bile acids
71. Development of a scintillation proximity assay for peroxisome proliferatoractivated receptor γ ligand binding domain
72. CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene
73. Molecular cloning of cDNA for cholesterol 7α-hydroxylase from rat fiver microsomes
74. A unified nomenclature system for the nuclear receptor superfamily
75. Steroidogenic factor 1: A key determinant of endocrine development and function
76. Bile acids: Natural ligands for an orphan nuclear receptor
77. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
78. Nuclear retinoic acid receptors: Cloning, analysis, and function
79. Bile acid excretion and cholesterol 7α-hydroxylase expression in hypercholesterolemia-resistant rabbits
80. Regulation of bile acid biosynthesis
81. Nuclear receptor regulation of cholesterol and bile acid metabolism
82. Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene
83. Dietary cholesterol and downregulation of cholesterol 7α-hydroxylase and cholesterol absorption in African green monkeys
84. Bile acid biosynthesis
85. Oxysterols: Modulators of cholesterol metabolism and other processes
86. Identification and characterization of a mouse oxysterol 7α-hydroxylase cDNA
87. Two 7α-hydroxylase enzymes in bile acid biosynthesis
88. Disruption of cholesterol 7α-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7α-hydroxylase
89. Marked reduction in bile acid synthesis in cholesterol 7α-hydroxylase-deficient mice does not lead to diminished cholesterol turnover or to hypercholesterolemia
90. Isolation of proteins that interact specifically with the retinoid X receptor: Two novel orphan receptors
91. Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei
92. Identification of a new inborn error in bile acid synthesis: Mutation of the oxysterol 7α-hydroxylase gene causes severe neonatal liver disease
93. NER, a new member of the gene family encoding the human steroid hormone nuclear receptor
94. Ubiquitous receptor: A receptor that modulates gene activation by retinoic acid and thyroid hormone receptors
95. Adenovirus-mediated transfer of a gene encoding cholesterol 7α-hydroxylase into hamsters increases hepatic enzyme activity and reduces plasma total and low density lipoprotein cholesterol
96. Overexpression of cholesterol 7α-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene
97. Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster, and rat
98. The squalene dioxide pathway of steroid biosynthesis
99. Effects of pregnenolone-16α-carbonitrile on the metabolism of cholesterol in rat fiver microsomes
100. A novel cytochrome P450 expressed primarily in brain
101. cDNA cloning and expression of the human hepatic bile acid-binding protein
102. HNF4 and COUPTFII interact to modulate transcription of the cholesterol 7α-hydroxylase gene (CYP7A1)
103. 3: Gonadrotropic regulation of the cognate mRNA in ovaries
104. Mammalian sex determination: A molecular drama
105. Regulation of cholesterol 7α-hydroxylase gene expression in Hep-G2 cells
106. OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor
107. Rates of sterol synthesis and uptake in the major organs of the rat in vivo
108. Cholesterol metabolism and excretion
109. Structure of the mouse cholesterol 7α-hydroxylase gene
110. Effects of cholic acid, chenodeoxycholic acid, and their related bile acids on cholesterol, phospholipid, and bile acid levels in serum, liver, bile, and feces of rats
111. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages: A transcriptional role for specific oxysterols
112. Regulation of sterol 12α-hydroxylase and cholic acid biosynthesis in the rat
113. Regulation of bile acid biosynthesis
114. Increased biliary lipid secretion in celiac disease
115. Absorption, metabolism, and serum concentrations of cholesterol in vegetarians: Effects of cholesterol feeding
116. Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis
117. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
118. Effects of four taurine-conjugated bile acids on mucosal uptake and lymphatic absorption of cholesterol in the rat
119. Nuclear-receptor ligands and ligandbinding domains
120. Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR
121. Nuclear orphan receptors: The search for novel ligands and signaling pathways
122. LXR, a nuclear receptor that defines a distinct retinoid response pathway
123. Structure and functions of human oxysterol 7α-hydroxylase cDNAs and gene CYP7B1
124. Ileal bile acid transport regulates bile acid pool synthesis, and plasma cholesterol levels differently in cholesterolfed rats and rabbits
125. Activation of the orphan receptor RIP 14 by retinoids
126. Nuclear receptors have distinct affinities for coactivators: Characterization by fluorescence resonance energy transfer