Statins inhibit synthesis of an oxysterol ligand for the liver X receptor in human macrophages with consequences for cholesterol flux

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 24, Issue 12, 2004, Pages 2365-2371

  Wong, Jenny ^a   Quinn, Carmel M ^a   Brown, Andrew J ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

24(S),25 epoxycholesterol; Human macrophage; Human monocyte derived macrophages; Liver X receptor; Pleiotropic; Statins; THP 1 cells

Indexed keywords

25 EPOXYCHOLESTEROL; ABC TRANSPORTER; ABC TRANSPORTER A1; CHOLESTEROL; COMPACTIN; LIVER X RECEPTOR ALPHA; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; OXYSTEROL; PROTEIN ABCG1; STATIN; UNCLASSIFIED DRUG;

ARTERY WALL; ARTICLE; CELL LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; FOAM CELL; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MACROPHAGE; PRIORITY JOURNAL; STEROL SYNTHESIS;

ATP-BINDING CASSETTE TRANSPORTERS; CELL DIFFERENTIATION; CELL LINE; CHOLESTEROL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIGANDS; LOVASTATIN; MACROPHAGES; MONOCYTES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TETRADECANOYLPHORBOL ACETATE;

EID: 10644229420     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000148707.93054.7d     Document Type: Article

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