Regulation of ABCA1 expression in human keratinocytes and murine epidermis

Journal of Lipid Research

Volumn 47, Issue 10, 2006, Pages 2248-2258

  Jiang, Yan J ^a   Lu, Biao ^a   Kim, Peggy ^a   Elias, Peter M ^a   Feingold, Kenneth R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ATP binding cassette transporter 1; Cultured human keratinocyte; Liver X receptor; Peroxisome proliferator activated receptor ; Peroxisome proliferator activated receptor ; Peroxisome proliferator activated receptor

Indexed keywords

ABC TRANSPORTER A1; ACETONE; CHOLESTEROL; CHOLESTEROL SULFATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN; MEVALONIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MEMBRANE PERMEABILITY; CELL TRANSPORT; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; EPIDERMIS; FEMALE; FETUS; FETUS DEVELOPMENT; GENE EXPRESSION REGULATION; GESTATION PERIOD; HUMAN; HUMAN CELL; KERATINOCYTE; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; UPREGULATION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, NORTHERN; CELL DIFFERENTIATION; CELLS, CULTURED; DNA-BINDING PROTEINS; ENZYME ACTIVATION; EPIDERMIS; FEMALE; FORESKIN; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; MALE; MICE; PPAR GAMMA; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RETINOID X RECEPTORS; RNA, MESSENGER;

EID: 33845595443     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M600163-JLR200     Document Type: Article

References (52)

1. Schurer, N. Y., and P. M. Elias. 1991. The biochemistry and function of stratum corneum lipids. Adv. Lipid Res. 24: 27-56.
2. Menon, G. K., K. R. Feingold, A. H. Moser, B. E. Brown, and P. M. Elias. 1985. De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements. J. Lipid Res. 26: 418-427.
3. Tsuruoka, H., W. Khovidhunkit, B. E. Brown, J. W. Fluhr, P. M. Elias, and K. R. Feingold. 2002. Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements. J. Biol. Chem. 277: 2916-2922.
4. Jackson, S. M., L. C. Wood, S. Lauer, J. M. Taylor, A. D. Cooper, P. M. Elias, and K. R. Feingold. 1992. Effect of cutaneous permeability barrier disruption on HMG-CoA reductase, LDL receptor, and apolipoprotein E mRNA levels in the epidermis of hairless mice. J. Lipid Res. 33: 1307-1314.
5. Feingold, K. R., M. Q. Man, G. K. Menon, S. S. Cho, B. E. Brown, and P. M. Elias. 1990. Cholesterol synthesis is required for cutaneous barrier function in mice. J. Clin. Invest. 86: 1738-1745.
6. Ye, J., A. Garg, C. Calhoun, K. R. Feingold, P. M. Elias, and R. Ghadially. 2002. Alterations in cytokine regulation in aged epidermis: implications for permeability barrier homeostasis and inflammation. I. IL-1 gene family. Exp. Dermatol. 11: 209-216.
7. Ghadially, R., B. E. Brown, K. Hanley, J. T. Reed, K. R. Feingold, and P. M. Elias. 1996. Decreased epidermal lipid synthesis accounts for altered barrier function in aged mice. J. Invest. Dermatol. 106: 1064-1069.
8. Epstein, E. H., M. L. Williams, and P. M. Elias. 1984. The epidermal cholesterol sulfate cycle. J. Am. Acad. Dermatol. 10: 866-868.
9. Elias, P. M., D. Crumrine, U. Rassner, J. P. Hachem, G. K. Menon, W. Man, M. H. Choy, L. Leypoldt, K. R. Feingold, and M. L. Williams. 2004. Basis for abnormal desquamation and permeability barrier dysfunction in RXLI. J. Invest. Dermatol. 122: 314-319.
10. Denning, M. F., M. G. Kazanietz, P. M. Blumberg, and S. H. Yuspa. 1995. Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes. Cell Growth Differ. 6: 1619-1626.
11. Downing, D. T., R. W. Dose, and W. Abraham. 1993. Interaction between sphingosine and cholesteryl sulfate in epidermal lipids. J. Lipid Res. 34: 563-569.
12. Hanley, K., L. Wood, D. C. Ng, S. S. He, P. Lau, A. Moser, P. M. Elias, D. D. Bikle, M. L. Williams, and K. R. Feingold. 2001. Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D. J. Lipid Res. 42: 390-398.
13. Attie, A. D., J. P. Kastelein, and M. R. Hayden. 2001. Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis. J. Lipid Res. 42: 1717-1726.
14. Oram, J. F. 2000. Tangier disease and ABCA1. Biochim. Biophys. Acta. 1529: 321-330.
15. Marcil, M., A. Brooks-Wilson, S. M. Clee, K. Roomp, L. H. Zhang, L. Yu, J. A. Collins, M. van Dam, H. O. Molhuizen, O. Loubster, et al. 1999. Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux. Lancet. 354: 1341-1346.
16. Brooks-Wilson, A., M. Marcil, S. M. Clee, L. H. Zhang, K. Roomp, M. van Dam, L. Yu, C. Brewer, J. A. Collins, H. O. Molhuizen, et al. 1999. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat. Genet. 22: 336-345.
17. Genest, J., Jr., M. Marcil, M. Denis, and L. Yu. 1999. High density lipoproteins in health and in disease. J. Investig. Med. 47: 31-42.
18. Marcil, M., L. Yu, L. Krimbou, B. Boucher, J. F. Oram, J. S. Cohn, and J. Genest, Jr. 1999. Cellular cholesterol transport and efflux in fibroblasts are abnormal in subjects with familial HDL deficiency. Arterioscler. Thromb. Vasc. Biol. 19: 159-169.
19. McNeish, J., R. J. Aiello, D. Guyot, T. Turi, C. Gabel, C. Aldinger, K. L. Hoppe, M. L. Roach, L. J. Royer, J. de Wet, et al. 2000. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. Proc. Natl. Acad. Sci. USA. 97: 4245-4250.
20. Murthy, S., E. Born, S. N. Mathur, and F. J. Field. 2002. LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. J. Lipid Res. 43: 1054-1064.
21. Rigamonti, E., L. Helin, S. Lestavel, A. L. Mutka, M. Lepore, C. Fontaine, M. A. Bouhlel, S. Bultel, J. C. Fruchart, E. Ikonen, et al. 2005. Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ. Res. 97: 682-689.
22. Venkateswaran, A., B. A. Laffitte, S. B. Joseph, P. A. Mak, D. C. Wilpitz, P. A. Edwards, and P. Tontonoz. 2000. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc. Natl. Acad. Sci. USA. 97: 12097-12102.
23. Chawla, A., W. A. Boisvert, C. H. Lee, B. A. Laffitte, Y. Barak, S. B. Joseph, D. Liao, L. Nagy, P. A. Edwards, L. K. Curtiss, et al. 2001. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol. Cell. 7: 161-171.
24. Laffitte, B. A., S. B. Joseph, R. Walczak, L. Pei, D. C. Wilpitz, J. L. Collins, and P. Tontonoz. 2001. Autoregulation of the human liver X receptor alpha promoter. Mol. Cell. Biol. 21: 7558-7568.
25. Singaraja, R. R., V. Bocher, E. R. James, S. M. Clee, L. H. Zhang, B. R. Leavitt, B. Tan, A. Brooks-Wilson, A. Kwok, N. Bissada, et al. 2001. Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and apoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1. J. Biol. Chem. 276: 33969-33979.
26. Singaraja, R. R., E. R. James, J. Crim, H. Visscher, A. Chatterjee, and M. R. Hayden. 2005. Alternate transcripts expressed in response to diet reflect tissue-specific regulation of ABCA1. J. Lipid Res. 46: 2061-2071.
27. Hanley, K., L. G. Komuves, D. C. Ng, K. Schoonjans, S. S. He, P. Lau, D. D. Bikle, M. L. Williams, P. M. Elias, J. Auwerx, et al. 2000. Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha. J. Biol. Chem. 275: 11484-11491.
28. Komuves, L. G., M. Schmuth, A. J. Fowler, P. M. Elias, K. Hanley, M. Q. Man, A. H. Moser, J. M. Lobaccaro, M. L. Williams, D. J. Mangelsdorf, et al. 2002. Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. J. Invest. Dermatol. 118: 25-34.
29. Westergaard, M., J. Henningsen, M. L. Svendsen, C. Johansen, U. B. Jensen, H. D. Schroder, I. Kratchmarova, R. K. Berge, L. Iversen, L. Bolund, et al. 2001. Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid. J. Invest. Dermatol. 116: 702-712.
30. Kuenzli, S., and J. H. Saurat. 2003. Peroxisome proliferator-activated receptors in cutaneous biology. Br. J. Dermatol. 149: 229-236.
31. Hanley, K., Y. Jiang, S. S. He, M. Friedman, P. M. Elias, D. D. Bikle, M. L. Williams, and K. R. Feingold. 1998. Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha. J. Invest. Dermatol. 110: 368-375.
32. Hanley, K., L. G. Komuves, N. M. Bass, S. S. He, Y. Jiang, D. Crumrine, R. Appel, M. Friedman, J. Bettencourt, K. Min, et al. 1999. Fetal epidermal differentiation and barrier development in vivo is accelerated by nuclear hormone receptor activators. J. Invest. Dermatol. 113: 788-795.
33. Hanley, K., D. C. Ng, S. S. He, P. Lau, K. Min, P. M. Elias, D. D. Bikle, D. J. Mangelsdorf, M. L. Williams, and K. R. Feingold. 2000. Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. J. Invest. Dermatol. 114: 545-553.
34. Komuves, L. G., K. Hanley, M. Q. Man, P. M. Elias, M. L. Williams, and K. R. Feingold. 2000. Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARalpha activators restores tissue homeostasis. J. Invest. Dermatol. 115: 361-367.
35. Jiang, Y. J., P. Kim, P. M. Elias, and K. R. Feingold. 2005. LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes. J. Lipid Res. 46: 2657-2666.
36. Proksch, E., P. M. Elias, and K. R. Feingold. 1990. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in murine epidermis. Modulation of enzyme content and activation state by barrier requirements. J. Clin. Invest. 85: 874-882.
37. Hanley, K., Y. Jiang, C. Katagiri, K. R. Feingold, and M. L. Williams. 1997. Epidermal steroid sulfatase and cholesterol sulfotransferase are regulated during late gestation in the fetal rat. J. Invest. Dermatol. 108: 871-875.
38. Proksch, E., P. M. Elias, and K. R. Feingold. 1991. Localization and regulation of epidermal 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by barrier requirements. Biochim. Biophys. Acta. 1083: 71-79.
39. Kielar, D., W. E. Kaminski, G. Liebisch, A. Piehler, J. J. Wenzel, C. Mohle, S. Heimerl, T. Langmann, S. O. Friedrich, A. Bottcher, et al. 2003. Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization. J. Invest. Dermatol. 121: 465-474.
40. Williams, M. L., K. Hanley, P. M. Elias, and K. R. Feingold. 1998. Ontogeny of the epidermal permeability barrier. J. Investig. Dermatol. Symp. Proc. 3: 75-79.
41. Elias, P. M., and G. K. Menon. 1991. Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv. Lipid Res. 24: 1-26.
42. Man, M. Q., K. R. Feingold, and P. M. Elias. 1993. Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin. Arch. Dermatol. 129: 728-738.
43. Proksch, E., K. R. Feingold, M. Q. Man, and P. M. Elias. 1991. Barrier function regulates epidermal DNA synthesis. J. Clin. Invest. 87: 1668-1673.
44. Harris, I. R., A. M. Farrell, R. A. Memon, C. Grunfeld, P. M. Elias, and K. R. Feingold. 1998. Expression and regulation of mRNA for putative fatty acid transport related proteins and fatty acyl CoA synthase in murine epidermis and cultured human keratinocytes. J. Invest. Dermatol. 111: 722-726.
45. Schmitz, G., and T. Langmann. 2005. Transcriptional regulatory networks in lipid metabolism control ABCA1 expression. Biochim. Biophys. Acta. 1735: 1-19.
46. Chinetti, G., S. Lestavel, V. Bocher, A. T. Remaley, B. Neve, I. P. Torra, E. Teissier, A. Minnich, M. Jaye, N. Duverger, et al. 2001. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat. Med. 7: 53-58.
47. Harris, I. R., A. M. Farrell, W. M. Holleran, S. Jackson, C. Grunfeld, P. M. Elias, and K. R. Feingold. 1998. Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis. J. Lipid Res. 39: 412-422.
48. Horton, J. D., J. L. Goldstein, and M. S. Brown. 2002. SREBPs: transcriptional mediators of lipid homeostasis. Cold Spring Harb. Symp. Quant. Biol. 67: 491-498.
49. Costet, P., F. Lalanne, M. C. Gerbod-Giannone, J. R. Molina, X. Fu, E. G. Lund, L. J. Gudas, and A. R. Tall. 2003. Retinoic acid receptor-mediated induction of ABCA1 in macrophages. Mol. Cell. Biol. 23: 7756-7766.
50. Wagsater, D., J. Dimberg, and A. Sirsjo. 2003. Induction of ATP-binding cassette A1 by all-trans retinoic acid: possible role of liver X receptor-alpha. Int. J. Mol. Med. 11: 419-423.
51. Rubic, T., M. Trottmann, and R. L. Lorenz. 2004. Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin. Biochem. Pharmacol. 67: 411-419.
52. Khovidhunkit, W., A. H. Moser, J. K. Shigenaga, C. Grunfeld, and K. R. Feingold. 2003. Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR. J. Lipid Res. 44: 1728-1736.