Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol

Journal of Biological Chemistry

Volumn 282, Issue 8, 2007, Pages 5207-5216

  Beyea, Michael M ^a,b   Heslop, Claire L ^a,b   Sawyez, Cynthia G ^a,c   Edwards, Jane Y ^a,c   Markle, Janet G ^a   Hegele, Robert A ^a,b,c   Huff, Murray W ^a,b,c,d  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c WESTERN UNIVERSITY   (Canada)

^d NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEIN LIPASE; LIVER X RECEPTORS (LXR); LXR ACTIVATORS; OXIDOSQUALENE:LANOSTEROL CYCLASE (OSC);

CHOLESTEROL; ENZYMES; FATTY ACIDS; GENETIC ENGINEERING; SYNTHESIS (CHEMICAL);

MACROPHAGES;

25 EPOXYCHOLESTEROL; ABC TRANSPORTER; ABC TRANSPORTER A1; ABC TRANSPORTER G1; APOLIPOPROTEIN E; CHOLESTEROL DERIVATIVE; FATTY ACID SYNTHASE; LIPOPROTEIN LIPASE; LIVER X RECEPTOR; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 24,25 EPOXYCHOLESTEROL; 24,25-EPOXYCHOLESTEROL; ABCG1 PROTEIN, HUMAN; CELL RECEPTOR; CHOLESTEROL; DNA BINDING PROTEIN; DRUG DERIVATIVE; ENZYME INHIBITOR; FATTY ACID; LANOSTEROL SYNTHASE; MUTASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

ARTICLE; CHOLESTEROL SYNTHESIS; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN CELL; LIPOGENESIS; MACROPHAGE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; UPREGULATION; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; FOAM CELL; GENETICS; METABOLISM;

APOLIPOPROTEINS E; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CHOLESTEROL; DNA-BINDING PROTEINS; ENZYME INHIBITORS; FATTY ACIDS; FOAM CELLS; HUMANS; INTRAMOLECULAR TRANSFERASES; LIPOPROTEIN LIPASE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIGLYCERIDES; UP-REGULATION;

EID: 34247139296     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611063200     Document Type: Article

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