27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells

Journal of Biological Chemistry

Volumn 276, Issue 42, 2001, Pages 38378-38387

  Fu, Xuan ^a   Menke, John G ^a   Chen, Yuli ^a   Zhou, Gaochao ^a   MacNaul, Karen L ^a   Wright, Samuel D ^a   Sparrow, Carl P ^a   Lund, Erik G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; LIPIDS; METABOLISM; PROTEINS; SKIN;

LIGANDS;

CELLS;

20 HYDROXYCHOLESTEROL; 22 HYDROXYCHOLESTEROL; 25 EPOXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; ABC TRANSPORTER A1; CELL NUCLEUS RECEPTOR; CHOLESTANE DERIVATIVE; CHOLESTENOIC ACID; CHOLESTEROL; GENE PRODUCT; LIVER X RECEPTOR; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; PROTEIN ABCG1; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG; 27-HYDROXYCHOLESTEROL; ABC TRANSPORTER; ABCG1 PROTEIN, HUMAN; CCAAT ENHANCER BINDING PROTEIN; CELL RECEPTOR; CHOLEST 4 EN 3 ONE; CHOLESTEROL DERIVATIVE; COMPLEMENTARY DNA; DNA BINDING PROTEIN; LIGAND; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RETINOIC ACID RECEPTOR; SREBF1 PROTEIN, HUMAN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE INDUCTION; HUMAN; HUMAN CELL; HYDROXYLATION; LIPID METABOLISM; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SKIN FIBROBLAST; CELL CULTURE; CEREBROTENDINOUS XANTHOMATOSIS; DOSE RESPONSE; FIBROBLAST; GENETIC TRANSFECTION; MASS FRAGMENTOGRAPHY; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; TIME;

ATP-BINDING CASSETTE TRANSPORTERS; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; CHOLESTENONES; CHOLESTEROL; CHOLESTEROL, LDL; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROXYCHOLESTEROLS; LIGANDS; MACROPHAGES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION; XANTHOMATOSIS, CEREBROTENDINOUS;

EID: 0035914330     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105805200     Document Type: Article

References (64)

1. Repa, J. J., and Mangelsdorf, D. J. (1999) Curr. Opin. Biotechnol. 10, 557-563
2. Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., and Mangelsdorf, D. J. (1996) Nature 383, 728-731
3. Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J. L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., and Willson, T. M. (1997) J. Biol. Chem. 272, 3137-3140
4. Forman, B. M., Ruan, B., Chen, J., Schroepfer, G. J., Jr., and Evans, R. M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 10588-10593
5. Spencer, T. A., Li, D., Russel, J. S., Collins, J. L., Bledsoe, R. K., Consler, T. G., Moore, L. B., Galardi, C. M., McKee, D. D., Moore, J. T., Watson, M. A., Parks, D. J., Lambert, M. H., and Willson, T. M. (2001) J. Med. Chem. 44, 886-897
6. Spencer, T. A. (1994) Acc. Chem. Res. 27, 83-90
7. Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. M., Hammer, R. E., and Mangelsdorf, D. J. (1998) Cell 93, 693-704
8. Luo, Y., and Tall, A. R. (2000) J. Clin. Invest. 105, 513-520
9. Venkateswaran, A., Repa, J. J., Lobaccaro, J. M., Bronson, A., Mangelsdorf, D. J., and Edwards, P. A. (2000) J. Biol. Chem. 275, 14700-14007
10. Costet, P., Luo, Y., Wang, N., and Tall, A. R. (2000) J. Biol. Chem. 275, 28240-28245
11. Schwartz, K., Lawn, R. M., and Wade, D. P. (2000) Biochem. Biophys. Res. Commun. 274, 794-802
12. Repa, J. J., Turley, S. D., Lobaccaro, J. A., Medina, J., Li, L., Lustig, K., Shan, B., Heyman, R. A., Dietschy, J. M., and Mangelsdorf, D. J. (2000) Science 289, 1524-1529
13. Venkateswaran, A., Laffitte, B. A., Joseph, S. B., Mak, P. A., Wilpitz, D. C., Edwards, P. A., and Tontonoz, P. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 12097-12102
14. Laffitte, B. A., Repa, J. J., Joseph, S. B., Wilpitz, D. C., Kast, H. R., Mangelsdorf, D. J., and Tontonoz, P. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 507-512
15. Repa, J. J., Liang, G., Ou, J., Bashmakov, Y., Lobaccaro, J. M., Shimomura, I., Shan, B., Brown, M. S., Goldstein, J. L., and Mangelsdorf, D. J. (2000) Genes Dev. 14, 2819-2830
16. Yoshikawa, T., Shimano, H., Amemiya-Kudo, M., Yahagi, N., Hasty, A. H., Matsuzaka, T., Okazaki, H., Tamura, Y., Iizuka, Y., Ohashi, K., Osuga, J. I., Harada, K., Gotoda, T., Kimura, S., Ishibashi, S., and Yamada, N. (2001) Mol. Cell. Biol. 21, 2991-3000
17. Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L. H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O., Loubser, O., Ouelette, B. F., Fichter, K., Ashbourne-Excoffon, K. J., Sensen, C. W., Scherer, S., Mott, S., Denis, M., Martindale, D., Frohlich, J., Morgan, K., Koop, B., Pimstone, S., Kastelein, J. J., Hayden, M. R., et al. (1999) Nat. Genet. 22, 336-345
18. Bodzioch, M., Orsó, E., Klucken, J., Langmann, T., Bottcher, A., Diederich, W., Drobnik, W., Barlage, S., Buchler, C., Porsch-Özcü rümez, M., Kaminski, W. E., Hahmann, H. W., Oette, K., Rothe, G., Aslanidis, C., Lackner, K. J., and Schmitz, G. (1999) Nat. Genet. 22, 347-351
19. Rust, S., Rosier, M., Funke, H., Real, J., Amoura, Z., Piette, J. C., Deleuze, J. F., Brewer, H. B., Duverger, N., Denefle, P., and Assmann, G. (1999) Nat. Genet. 22, 352-355
20. Lawn, R. M., Wade, D. P., Garvin, M. R., Wang, X., Schwartz, K., Porter, J. G., Seilhamer, J. J., Vaughan, A. M., and Oram, J. F. (1999) J. Clin. Invest. 104, R25-R31
21. Langmann, T., Klucken, J., Reil, M., Liebisch, G., Luciani, M. F., Chimini, G., Kaminski, W. E., and Schmitz, G. (1999) Biochem. Biophys. Res. Commun. 257, 29-33
22. Javitt, N. B. (2000) Biochim. Biophys. Acta 1529, 136-141
23. Dzeletovic, S., Breuer, O., Lund, E., and Diczfalusy, U. (1995) Anal. Biochem. 225, 73-80
24. Oftebro, H., Björkhem, I., Skrede, S., Schreiner, A., and Pedersen, J. I. (1980) J. Clin. Invest. 65, 1418-1430
25. Cali, J. J., Hsieh, C.-L., Francke, U., and Russell, D. W. (1991) J. Biol. Chem. 266, 7779-7783
26. Björkhem, I., and Boberg, K. M. (1995) in The Metabolic and Molecular Basis of Inherited Disease (Scriver, C. R., Beaudet, A. L., Sly, W. S., and Valle, D., eds) Vol. 2, pp. 2073-2099, McGraw-Hill Inc., New York
27. Shore, V., Salen, G., Cheng, F. W., Forte, T., Shefer, S., Tint, G. S., and Lindgren, F. T. (1981) J. Clin. Invest. 68, 1295-1304
28. Fujiyama, J., Kuriyama, M., Arima, S., Shibata, Y., Nagata, K., Takenaga, S., Tanaka, H., and Osame, M. (1991) Clin. Chim. Acta 200, 1-11
29. Basu, S. K., Goldstein, J. L., Anderson, G. W., and Brown, M. S. (1976) Proc. Natl. Acad. Sci. U. S. A. 73, 3178-3182
30. Goldstein, J. L., Ho, Y. K., Basu, S. K., and Brown, M. S. (1979) Proc. Natl. Acad. Sci. U. S. A. 76, 333-337
31. Wakamatsu, N., Hayashi, M., Kawai, H., Kondo, H., Gotoda, Y., Nishida, Y., Kondo, R., Tsuji, S., and Matsumoto, T. (1999) J. Neurol. Neurosurg. Psychiatry 67, 195-198
32. Wright, S. D., and Silverstein, S. C. (1982) J. Exp. Med. 156, 1149-1164
33. Hailman, E., Vasselon, T., Kelley, M., Busse, L. A., Hu, M. C., Lichenstein, H. S., Detmers, P. A., and Wright, S. D. (1996) J. Immunol. 156, 4384-4390
34. Zhou, G., Cummings, R., Li, Y., Mitra, S., Wilkinson, H. A., Elbrecht, A., Hermes, J. D., Schaeffer, J. M., Smith, R. G., and Moller, D. E. (1998) Mol. Endocrinol. 12, 1594-1604
35. Heid, C. A., Stevens, J., Livak, K. J., and Williams, P. M. (1996) Genome Res. 6, 986-994
36. Sambrook, J. F., and Russell, D. W. (eds) (2000) Molecular Cloning: A Laboratory Manual, 3rd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
37. Francis, G. A., Knopp, R. H., and Oram, J. F. (1995) J. Clin. Invest. 96, 78-87
38. Kaluzny, M. A., Duncan, L. A., Merritt, M. V., and Epps, D. E. (1985) J. Lipid Res. 26, 135-140
39. Klucken, J., Buchler, C., Orsó, E., Kaminski, W. E., Porsch-Özcürümez, M., Liebisch, G., Kapinsky, M., Diederich, W., Drobnik, W., Dean, M., Allikmets, R., and Schmitz, G. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 817-822
40. Kudo, K., Emmons, G. T., Casserly, E. W., Via, D. P., Smith, L. C., St. Pyrek, J., and Schroepfer, G. J., Jr. (1989) J. Lipid Res. 30, 1097-1111
41. Hultén, L. M., Lindmark, H., Diczfalusy, U., Björkhem, I., Ottosson, M., Liu, Y., Bondjers, G., and Wildund, O. (1996) J. Clin. Invest. 97, 461-468
42. Crisby, M., Nilsson, J., Kostulas, V., Björkhem, I., and Diczfalusy, U. (1997) Biochim. Biophys. Acta 1344, 278-285
43. Tamai, I., Yabuuchi, H., Nezu, J., Sai, Y., Oku, A., Shimane, M., and Tsuji, A. (1997) FEBS Lett. 419, 107-111
44. Babiker, A., Andersson, O., Lund, E ., Xiu, R. J., Deeb, S., Reshef, A., Leitersdorf, E., Diczfalusy, U., and Björkhem, I. (1997) J. Biol. Chem. 272, 26253-26261
45. Skrede, S., Björkhem, I., Kvittingen, E. A., Buchmann, M. S., Lie, S. O., East, C., and Grundy, S. (1986) J. Clin. Invest. 78, 729-735
46. Andersson, S., Davis, D. L., Dahlbäck, H., Jörnvall, H., and Russell, D. W. (1989) J. Biol. Chem. 264, 8222-8229
47. Björkhem, I. (1992) J. Lipid Res. 33, 455-471
48. Amemiya-Kudo, M., Shimano, H., Yoshikawa, T., Yahagi, N., Hasty, A. H., Okazaki, H., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Osuga, J., Harada, K., Gotoda, T., Sato, R., Kimura, S., Ishibashi, S., and Yamada, N. (2000) J. Biol. Chem. 275, 31078-31085
49. Rosen, H., Reshef, A., Maeda, N., Lippoldt, A., Shpizen, S., Triger, L., Eggertsen, G., Björkhem, I., and Leitersdorf, E. (1998) J. Biol. Chem. 273, 14805-14812
50. Repa, J. J., Lund, E. G., Horton, J. D., Leitersdorf, E., Russell, D. W., Dietschy, J. M., and Turley, S. D. (2000) J. Biol. Chem. 275, 39685-39692
51. Reiss, A. B., Martin, K. O., Javitt, N. B., Martin, D. W., Grossi, E. A., and Galloway, A. C. (1994) J. Lipid Res. 35, 1026-1030
52. Björkhem, I., Andersson, O., Diczfalusy, U., Sevastik, B., Duan, C., Xiu, R., and Lund, E. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 6592-8596
53. Lund, E., Andersson, O., Zhang, J., Babiker, A., Ahlborg, G., Diczfalusy, U., Einarsson, K., Sjövall, J., and Björkhem, I. (1996) Arterioscler. Thromb. Vasc. Biol. 16, 208-212
54. Setchell, K. D. R., Schwarz, M., O'Connell, N. C., Lund, E., G., Davis, D. L., Lathe, R., Thompson, H. R., Tyson, R. W., Sokol, R. J., and Russell, D. W. (1998) J. Clin. Invest. 102, 1690-1703
55. Björkhem, I., Starck, L., Andersson, U., Lütjohann, D., von Bahr, S., Pikuleva, I., Babiker, A., and Diczfalusy, U. (2001) J. Lipid Res. 42, 366-371
56. Behulova, D., Bzduch, V., Skodova, J., Dello Russo, A., Corso, G., Ponec, J., and Kasanicka, A. (2000) J. Inherit. Metab. Dis. 23, 413-415
57. Li-Hawkins, J., Lund, E. G., Turley, S. D., and Russell, D. W. (2000) J. Biol. Chem. 275, 16536-16542
58. Song, C., and Liao, S. (2000) Endocrinology 141, 4180-4184
59. Westman, J., Kallin, B., Björkhem, I., Nilsson, J., and Diczfalusy, U. (1998) Arterioscler. Thromb. Vasc. Biol. 18, 554-561
60. Babiker, A., Andersson, O., Lindblom, D., van der Linden, J., Wiklund, B., Lütjohann, D., Diczfalusy, U., and Björkhem, I. (1999) J. Lipid Res. 40, 1417-1425
61. DeBose-Boyd, R. A., Ou, J. F., Goldstein, J. L., and Brown, M. S. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 1477-1482
62. Janowski, B. A., Grogan, M. J., Jones, S. A., Wisely, G. B., Kliewer, S. A., Corey, E. J., and Mangelsdorf, D. J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 266-271
63. Spencer, T. A., Gayen, A. K., Phirwa, S., Nelson, J. A., Taylor, F. R., Kandutsch, A. A., and Erickson, S. K. (1965) J. Biol. Chem. 260, 13391-13394
64. Zhang, Z., Li, D., Blanchard, D. E., Lear, S. R., Erickson, S. K., and Spencer, T. A. (2001) J. Lipid Res. 42, 649-658