Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines

Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2002, Pages 1963-1966

  Collins, Jon L ^a   Binz, Jane G ^a   Plunket, Kelli D ^a   Morgan, Daniel G ^a   Beaudet, Elizabeth J ^a   Whitney, Karl D ^a   Kliewer, Steven A ^a   Willson, Timothy M ^a   Fivush, Adam M ^a   Watson, Michael A ^a   Galardi, Cristin M ^a   Lewis, Michael C ^a   Moore, Linda B ^a   Parks, Derek J ^a   Wilson, Joan G ^a   Tippin, Tim K ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; ABC TRANSPORTER; CARBOXYLIC ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER X RECEPTOR AGONIST; OXYSTEROL; STEROID RECEPTOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REPORTER GENE;

ADMINISTRATION, ORAL; AMINES; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL AVAILABILITY; CELL-FREE SYSTEM; CHOLESTEROL; CHOLESTEROL, HDL; DNA-BINDING PROTEINS; GENES, REPORTER; HUMANS; INTESTINE, SMALL; MACROPHAGES; MICE; MICE, INBRED C57BL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP; UP-REGULATION;

EID: 0037046543     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0255116     Document Type: Article

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