Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease

Neurobiology of Aging

Volumn 27, Issue 10, 2006, Pages 1431-1434

  Adighibe, Omanma ^a   Arepalli, Sampath ^a   Duckworth, Jaime ^a   Hardy, John ^a   Wavrant De Vrièze, Fabienne ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Alzheimer's disease; Cholesterol; Genetics; LXR gene

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; CHOLESTEROL METABOLISM; CHROMOSOME 19; FEMALE; GENE; GENE LOCUS; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR; SIBLING;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEINS E; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 19; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HETEROZYGOTE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; UNITED STATES; VARIATION (GENETICS);

EID: 33748182901     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2005.08.010     Document Type: Article

References (23)

1. Alberti S., Schuster G., Parini P., Feltkamp D., Diczfalusy U., Rudling M., et al. Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J Clin Invest 107 (2001) 565-573
2. Bertram L., and Tanzi R.E. Alzheimer's disease: one disorder, too many genes?. Hum Mol Genet 13 Spec No 1 (2004) R135-R141
3. Blacker D., Bertram L., Saunders A.J., Moscarillo T.J., Albert M.S., Wiener H., et al., NIMH Genetics Initiative Alzheimer's Disease Study Group. Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum Mol Genet 12 1 (2003) 23-32
4. Brown J., Theisler C., Silberman S., Magnuson D., Gottardi-Littell N., Lee J.M., et al. Differential expression of cholesterol hydroxylases in Alzheimer's disease. J Biol Chem 379 (2004) 34674-34681
5. Compton D., Wavrant DeVrieze F., Petersen R.C., Tangalos E., Li L., and Hardy J. Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers. Neurosci Lett 331 1 (2002) 60-62
6. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261 5123 (1993) 921-923
7. Fukuchi J., Song C., Ko A.L., and Liao S. Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors. Steroids 68 (2003) 685-691
8. Fukumoto H., Deng A., Irizarry M., Fitzgeralds M., and Rebeck W. Induction of cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonist increases secreted Aβ levels. J Biol Chem 277 50 (2002) 48508-48513
9. Jarvik G.P., Wijsman E.M., Kukull W.A., Schellenberg G.D., Yu C., and Larson E.B. Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology 45 6 (1995) 1092-1096
10. Kehoe P., Wavrant-De Vrièze F., Crook R., Wu W.S., Holmans P., Fenton L., et al. A full genome scan for late onset Alzheimer's disease. Hum Mol Genet 8 (1999) 237-245
11. Koldamova R.P., Lefterov I.M., Staufenbiel M., Wolfe D., Huang S., Glorioso J.C., et al. The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. J Biol Chem 280 6 (2005) 4079-4088
12. Koldamova R.P., Lefterov I.M., Ikonomovic M.D., Skoko J., Lefterov P.I., Isanski B.A., et al. 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. J Biol Chem 278 (2003) 13244-13256
13. Li Y., Tacey K., Doil L., van Luchene R., Garcia V., Rowland C., et al. Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study. Neurosci Lett 366 3 (2004) 268-271
14. Liang Y., Lin S., Beyer T.P., Zhang Y., Wu X., Bales K.R., et al. A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes. J Lipid Res 43 12 (2002) 2037-2041
15. Murthy S., Born E., Mathur S.N., and Field J. LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. J Lipid Res 43 (2002) 1054-1064
16. Myers A., Wavrant De-Vrieze F., Holmans P., Hamshere M., Crook R., Compton D., et al. Full genome screen for Alzheimer disease: stage II analysis. Am J Med Genet (Neuropsychiatric Genet) 114 (2002) 235-244
17. Notkola I.L., Sulkava R., Pekkanen J., Erkinjuntti T., Ehnholm C., Kivinen P., et al. Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease. Neuroepidemiology 17 1 (1998) 14-20
18. Pittman A.M., Myers A.J., Duckworth J., Bryden L., Hanson M., Abou-Sleiman P., et al. The structure of tau haplotype in controls and in progressive supranuclear palsy. Hum Mol Genet 13 (2004) 1267-1274
19. Poirier J. Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease. Neurobiol Aging 26 3 (2005) 355-361
20. Refolo L.M., Pappolla M.A., LaFrancois J., Malester B., Schmidt S.D., Thomas-Bryant T., et al. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis 8 5 (2001) 890-899
21. Sun Y., Yao J., Kim T.W., and Tall A.R. Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion. J Biol Chem 278 (2003) 27688-27694
22. Wijsman E.M., Daw E.W., Yu C., Payami H., Steinbart E.J., Nochlin D., et al. Evidence for a novel late-onset Alzheimer's disease locus on chromosome 19p13.2. Am J Hum Genet 75 (2004) 398-409
23. Wolozin B. Cholesterol and biology of Alzheimer's disease. Neuron 41 (2004) 7-10