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Volumn 61, Issue , 2011, Pages 373-415

Molecular Pharmacology, Physiology, and Structure of the P2Y Receptors

Author keywords

G protein; Nucleotide; P2Y receptor

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; CLOPIDOGREL; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; INOSITOL; LIPID; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHOLIPASE C BETA2; PHOSPHOLIPASE C BETA3; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y11 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; RHODOPSIN; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

EID: 79955961675     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385526-8.00012-6     Document Type: Chapter
Times cited : (109)

References (272)
  • 1
    • 33745742679 scopus 로고    scopus 로고
    • International Union of Pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: From molecular mechanisms and pathophysiology to therapy
    • Abbracchio M.P., Burnstock G., Boeynaems J.M., Barnard E.A., Boyer J.L., Kennedy C., et al. International Union of Pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: From molecular mechanisms and pathophysiology to therapy. Pharmacological Reviews 2006, 58:281-341.
    • (2006) Pharmacological Reviews , vol.58 , pp. 281-341
    • Abbracchio, M.P.1    Burnstock, G.2    Boeynaems, J.M.3    Barnard, E.A.4    Boyer, J.L.5    Kennedy, C.6
  • 10
    • 77957055780 scopus 로고
    • Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors
    • Academic Press, USA, P.M. Conn, S.C. Sealfon (Eds.)
    • Ballesteros J.A., Weinstein H. Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors. Methods in Neurosciences 1995, Vol. 25:366-428. Academic Press, USA. P.M. Conn, S.C. Sealfon (Eds.).
    • (1995) Methods in Neurosciences , vol.25 , pp. 366-428
    • Ballesteros, J.A.1    Weinstein, H.2
  • 12
    • 77955482425 scopus 로고    scopus 로고
    • Synthesis of alkyl- and aryl-amino-substituted anthraquinone derivatives by microwave-assisted copper(0)-catalyzed Ullmann coupling reactions
    • Baqi Y., Müller C.E. Synthesis of alkyl- and aryl-amino-substituted anthraquinone derivatives by microwave-assisted copper(0)-catalyzed Ullmann coupling reactions. Nature Protocols 2010, 5:945-953.
    • (2010) Nature Protocols , vol.5 , pp. 945-953
    • Baqi, Y.1    Müller, C.E.2
  • 18
    • 77949776136 scopus 로고    scopus 로고
    • 12 -ADP receptor polymorphism on the efficacy of clopidogrel dose-adjustment according to platelet reactivity monitoring in coronary artery disease patients
    • 12 -ADP receptor polymorphism on the efficacy of clopidogrel dose-adjustment according to platelet reactivity monitoring in coronary artery disease patients. Thrombosis Research 2010, 125:e167-e170.
    • (2010) Thrombosis Research , vol.125
    • Bonello, L.1    Bonello-Palot, N.2    Armero, S.3    Bonello, C.4    Mokhtar, O.A.5    Arques, S.6
  • 19
    • 0346367328 scopus 로고
    • Aggregation of blood platelets by adenosine diphosphate and its reversal
    • Born G.V. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962, 194:927-929.
    • (1962) Nature , vol.194 , pp. 927-929
    • Born, G.V.1
  • 25
    • 0028170436 scopus 로고
    • Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors
    • Boyer J.L., Zohn I.E., Jacobson K.A., Harden T.K. Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors. British Journal of Pharmacology 1994, 113:614-620.
    • (1994) British Journal of Pharmacology , vol.113 , pp. 614-620
    • Boyer, J.L.1    Zohn, I.E.2    Jacobson, K.A.3    Harden, T.K.4
  • 27
  • 29
    • 34248576759 scopus 로고    scopus 로고
    • Physiology and pathophysiology of purinergic neurotransmission
    • Burnstock G. Physiology and pathophysiology of purinergic neurotransmission. Physiological Reviews 2007, 87:659-797.
    • (2007) Physiological Reviews , vol.87 , pp. 659-797
    • Burnstock, G.1
  • 30
    • 0022178232 scopus 로고
    • Is there a basis for distinguishing two types of P2-purinoceptor?
    • Burnstock G., Kennedy C. Is there a basis for distinguishing two types of P2-purinoceptor?. General Pharmacology 1985, 16:433-440.
    • (1985) General Pharmacology , vol.16 , pp. 433-440
    • Burnstock, G.1    Kennedy, C.2
  • 38
    • 0028819714 scopus 로고
    • Molecular cloning and functional analysis of a novel P2 nucleotide receptor
    • Chang K., Hanaoka K., Kumada M., Takuwa Y. Molecular cloning and functional analysis of a novel P2 nucleotide receptor. Journal of Biological Chemistry 1995, 270:26152-26158.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 26152-26158
    • Chang, K.1    Hanaoka, K.2    Kumada, M.3    Takuwa, Y.4
  • 41
    • 0030865162 scopus 로고    scopus 로고
    • The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge
    • Charlton M.E., Williams A.S., Fogliano M., Sweetnam P.M., Duman R.S. The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge. Brain Research 1997, 764:141-148.
    • (1997) Brain Research , vol.764 , pp. 141-148
    • Charlton, M.E.1    Williams, A.S.2    Fogliano, M.3    Sweetnam, P.M.4    Duman, R.S.5
  • 43
    • 0029988538 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor
    • Chen Z.P., Krull N., Xu S., Levy A., Lightman S.L. Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor. Endocrinology 1996, 137:1833-1840.
    • (1996) Endocrinology , vol.137 , pp. 1833-1840
    • Chen, Z.P.1    Krull, N.2    Xu, S.3    Levy, A.4    Lightman, S.L.5
  • 48
    • 0031437421 scopus 로고    scopus 로고
    • Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase
    • Communi D., Govaerts C., Parmentier M., Boeynaems J.M. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. Journal of Biological Chemistry 1997, 272:31969-31973.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 31969-31973
    • Communi, D.1    Govaerts, C.2    Parmentier, M.3    Boeynaems, J.M.4
  • 53
    • 0018804588 scopus 로고
    • ADP is a potent inhibitor of human platelet plasma membrane adenylate cyclase
    • Cooper D.M., Rodbell M. ADP is a potent inhibitor of human platelet plasma membrane adenylate cyclase. Nature 1979, 282:517-518.
    • (1979) Nature , vol.282 , pp. 517-518
    • Cooper, D.M.1    Rodbell, M.2
  • 55
    • 6044234752 scopus 로고    scopus 로고
    • Architecture of P2Y nucleotide receptors: Structural comparison based on sequence analysis, mutagenesis, and homology modeling
    • Costanzi S., Mamedova L., Gao Z.G., Jacobson K.A. Architecture of P2Y nucleotide receptors: Structural comparison based on sequence analysis, mutagenesis, and homology modeling. Journal of Medicinal Chemistry 2004, 47:5393-5404.
    • (2004) Journal of Medicinal Chemistry , vol.47 , pp. 5393-5404
    • Costanzi, S.1    Mamedova, L.2    Gao, Z.G.3    Jacobson, K.A.4
  • 61
    • 77954879546 scopus 로고    scopus 로고
    • 1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3', 5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier
    • 1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3', 5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier. Bioconjugate Chemistry 2010, 21:1190-1205.
    • (2010) Bioconjugate Chemistry , vol.21 , pp. 1190-1205
    • de Castro, S.1    Maruoka, H.2    Hong, K.3    Kilbey, S.M.4    Costanzi, S.5    Hechler, B.6
  • 64
    • 0037588974 scopus 로고    scopus 로고
    • 12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270
    • 12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270. Blood 2003, 101:3908-3914.
    • (2003) Blood , vol.101 , pp. 3908-3914
    • Ding, Z.1    Kim, S.2    Dorsam, R.T.3    Jin, J.4    Kunapuli, S.P.5
  • 69
    • 84940815279 scopus 로고
    • The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart
    • Drury A.N., Szent-Györgyi A. The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. Journal de Physiologie 1929, 68:213-237.
    • (1929) Journal de Physiologie , vol.68 , pp. 213-237
    • Drury, A.N.1    Szent-Györgyi, A.2
  • 73
    • 70249090374 scopus 로고    scopus 로고
    • Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
    • Elliott M.R., Chekeni F.B., Trampont P.C., Lazarowski E.R., Kadl A., Walk S.F., et al. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature 2009, 461:282-286.
    • (2009) Nature , vol.461 , pp. 282-286
    • Elliott, M.R.1    Chekeni, F.B.2    Trampont, P.C.3    Lazarowski, E.R.4    Kadl, A.5    Walk, S.F.6
  • 76
    • 4944262878 scopus 로고    scopus 로고
    • 12 receptor in nucleotide inhibition of exocytosis from bovine chromaffin cells
    • 12 receptor in nucleotide inhibition of exocytosis from bovine chromaffin cells. Molecular Pharmacology 2004, 66:601-611.
    • (2004) Molecular Pharmacology , vol.66 , pp. 601-611
    • Ennion, S.J.1    Powell, A.D.2    Seward, E.P.3
  • 77
    • 0028987857 scopus 로고
    • Site-directed mutagenesis of P2U purinoceptors. Positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity
    • Erb L., Garrad R., Wang Y., Quinn T., Turner J.T., Weisman G.A. Site-directed mutagenesis of P2U purinoceptors. Positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity. Journal of Biological Chemistry 1995, 270:4185-4188.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 4185-4188
    • Erb, L.1    Garrad, R.2    Wang, Y.3    Quinn, T.4    Turner, J.T.5    Weisman, G.A.6
  • 84
    • 0034978187 scopus 로고    scopus 로고
    • Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs
    • Foster C.J., Prosser D.M., Agans J.M., Zhai Y., Smith M.D., Lachowicz J.E., et al. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. Journal of Clinical Investigation 2001, 107:1591-1598.
    • (2001) Journal of Clinical Investigation , vol.107 , pp. 1591-1598
    • Foster, C.J.1    Prosser, D.M.2    Agans, J.M.3    Zhai, Y.4    Smith, M.D.5    Lachowicz, J.E.6
  • 85
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
    • Fredriksson R., Lagerstrom M.C., Lundin L.G., Schioth H.B. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Molecular Pharmacology 2003, 63:1256-1272.
    • (2003) Molecular Pharmacology , vol.63 , pp. 1256-1272
    • Fredriksson, R.1    Lagerstrom, M.C.2    Lundin, L.G.3    Schioth, H.B.4
  • 86
    • 0035885861 scopus 로고    scopus 로고
    • Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs
    • Freeman K., Tsui P., Moore D., Emson P.C., Vawter L., Naheed S., et al. Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs. Genomics 2001, 78:124-128.
    • (2001) Genomics , vol.78 , pp. 124-128
    • Freeman, K.1    Tsui, P.2    Moore, D.3    Emson, P.C.4    Vawter, L.5    Naheed, S.6
  • 95
    • 14944378002 scopus 로고    scopus 로고
    • Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues
    • Gorzalka S., Vittori S., Volpini R., Cristalli G., von Kügelgen I., Müller C.E. Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Molecular Pharmacology 2005, 67:955-964.
    • (2005) Molecular Pharmacology , vol.67 , pp. 955-964
    • Gorzalka, S.1    Vittori, S.2    Volpini, R.3    Cristalli, G.4    von Kügelgen, I.5    Müller, C.E.6
  • 98
    • 61949087315 scopus 로고    scopus 로고
    • The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents
    • 10.1186/1471-2164-10-24
    • Haitina T., Fredriksson R., Foord S.M., Schiöth H.B., Gloriam D.E. The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents. BMC Genomics 2009, 10:24. 10.1186/1471-2164-10-24.
    • (2009) BMC Genomics , vol.10 , pp. 24
    • Haitina, T.1    Fredriksson, R.2    Foord, S.M.3    Schiöth, H.B.4    Gloriam, D.E.5
  • 103
    • 0031593698 scopus 로고    scopus 로고
    • 1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel
    • 1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel. British Journal Haematology 1998, 103:858-866.
    • (1998) British Journal Haematology , vol.103 , pp. 858-866
    • Hechler, B.1    Eckly, A.2    Ohlmann, P.3    Cazenave, J.P.4    Gachet, C.5
  • 108
    • 0027268226 scopus 로고
    • Inhibitory effect of clopidogrel on platelet adhesion and intimal proliferation after arterial injury in rabbits
    • Herbert J.M., Tissinier A., Defreyn G., Maffrand J.P. Inhibitory effect of clopidogrel on platelet adhesion and intimal proliferation after arterial injury in rabbits. Arteriosclerosis and Thrombosis 1993, 13:1171-1179.
    • (1993) Arteriosclerosis and Thrombosis , vol.13 , pp. 1171-1179
    • Herbert, J.M.1    Tissinier, A.2    Defreyn, G.3    Maffrand, J.P.4
  • 117
    • 57649213524 scopus 로고    scopus 로고
    • Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2
    • Hoffmann C., Ziegler N., Reiner S., Krasel C., Lohse M.J. Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2. Journal of Biological Chemistry 2008, 283:30933-30941.
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 30933-30941
    • Hoffmann, C.1    Ziegler, N.2    Reiner, S.3    Krasel, C.4    Lohse, M.J.5
  • 118
    • 0035843178 scopus 로고    scopus 로고
    • Identification of the platelet ADP receptor targeted by antithrombotic drugs
    • Hollopeter G., Jantzen H.M., Vincent D., Li G., England L., Ramakrishnan V., et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 2001, 409:202-207.
    • (2001) Nature , vol.409 , pp. 202-207
    • Hollopeter, G.1    Jantzen, H.M.2    Vincent, D.3    Li, G.4    England, L.5    Ramakrishnan, V.6
  • 125
    • 78449310435 scopus 로고    scopus 로고
    • GPCR ligand-dendrimer (GLiDe) conjugates: Future smart drugs?
    • Jacobson K.A. GPCR ligand-dendrimer (GLiDe) conjugates: Future smart drugs?. Trends in Pharmacological Sciences 2010, 31:575-579.
    • (2010) Trends in Pharmacological Sciences , vol.31 , pp. 575-579
    • Jacobson, K.A.1
  • 129
    • 62949141274 scopus 로고    scopus 로고
    • 12 receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial
    • 12 receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial. American Heart Journal 2009, 157:599-605.
    • (2009) American Heart Journal , vol.157 , pp. 599-605
    • James, S.1    Akerblom, A.2    Cannon, C.P.3    Emanuelsson, H.4    Husted, S.5    Katus, H.6
  • 134
    • 0031916728 scopus 로고    scopus 로고
    • 1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets
    • 1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. Journal of Biological Chemistry 1998, 273:2030-2034.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 2030-2034
    • Jin, J.1    Daniel, J.L.2    Kunapuli, S.P.3
  • 143
    • 42149181885 scopus 로고    scopus 로고
    • Structural diversity of G protein-coupled receptors and significance for drug discovery
    • Lagerström M.C., Schiöth H.B. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nature Reviews. Drug Discovery 2008, 7:339-357.
    • (2008) Nature Reviews. Drug Discovery , vol.7 , pp. 339-357
    • Lagerström, M.C.1    Schiöth, H.B.2
  • 145
    • 0030882314 scopus 로고    scopus 로고
    • Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation
    • Lazarowski E.R., Homolya L., Boucher R.C., Harden T.K. Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation. Journal of Biological Chemistry 1997, 272:24348-24354.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 24348-24354
    • Lazarowski, E.R.1    Homolya, L.2    Boucher, R.C.3    Harden, T.K.4
  • 146
    • 0035087488 scopus 로고    scopus 로고
    • Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder
    • Lazarowski E.R., Rochelle L.G., O'Neal W.K., Ribeiro C.M., Grubb B.R., Zhang V., et al. Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder. Journal of Pharmacology and Experimental Therapeutics 2001, 297:43-49.
    • (2001) Journal of Pharmacology and Experimental Therapeutics , vol.297 , pp. 43-49
    • Lazarowski, E.R.1    Rochelle, L.G.2    O'Neal, W.K.3    Ribeiro, C.M.4    Grubb, B.R.5    Zhang, V.6
  • 147
    • 0029162304 scopus 로고
    • Pharmacological selectivity of the cloned human P2U-purinoceptor: Potent activation by diadenosine tetraphosphate
    • Lazarowski E.R., Watt W.C., Stutts M.J., Boucher R.C., Harden T.K. Pharmacological selectivity of the cloned human P2U-purinoceptor: Potent activation by diadenosine tetraphosphate. British Journal of Pharmacology 1995, 116:1619-1627.
    • (1995) British Journal of Pharmacology , vol.116 , pp. 1619-1627
    • Lazarowski, E.R.1    Watt, W.C.2    Stutts, M.J.3    Boucher, R.C.4    Harden, T.K.5
  • 153
    • 0031577327 scopus 로고    scopus 로고
    • The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses
    • Li Q., Schachter J.B., Harden T.K., Nicholas R.A. The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. Biochemical and Biophysical Research Communications 1997, 236:455-460.
    • (1997) Biochemical and Biophysical Research Communications , vol.236 , pp. 455-460
    • Li, Q.1    Schachter, J.B.2    Harden, T.K.3    Nicholas, R.A.4
  • 160
    • 77950838144 scopus 로고    scopus 로고
    • Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior
    • Malin S.A., Molliver D.C. Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior. Molecular Pain 2009, 6:21.
    • (2009) Molecular Pain , vol.6 , pp. 21
    • Malin, S.A.1    Molliver, D.C.2
  • 166
    • 73949115258 scopus 로고    scopus 로고
    • NF546 [4, 4'-(carbonylbis(imino-3, 1-phenylene-carbonylimino-3, 1-(4-methyl-phenylene)-carbonylimino))-bis(1, 3-xylene-alpha, alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells
    • Meis S., Hamacher A., Hongwiset D., Marzian C., Wiese M., Eckstein N., et al. NF546 [4, 4'-(carbonylbis(imino-3, 1-phenylene-carbonylimino-3, 1-(4-methyl-phenylene)-carbonylimino))-bis(1, 3-xylene-alpha, alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. Journal of Pharmacology and Experimental Therapeutics 2010, 332:238-247.
    • (2010) Journal of Pharmacology and Experimental Therapeutics , vol.332 , pp. 238-247
    • Meis, S.1    Hamacher, A.2    Hongwiset, D.3    Marzian, C.4    Wiese, M.5    Eckstein, N.6
  • 167
    • 69249206623 scopus 로고    scopus 로고
    • G protein-coupled receptor hetero-dimerization: Contribution to pharmacology and function
    • Milligan G. G protein-coupled receptor hetero-dimerization: Contribution to pharmacology and function. British Journal of Pharmacology 2009, 158:5-14.
    • (2009) British Journal of Pharmacology , vol.158 , pp. 5-14
    • Milligan, G.1
  • 174
    • 0036431844 scopus 로고    scopus 로고
    • P2-pyrimidinergic receptors and their ligands
    • Müller C.E. P2-pyrimidinergic receptors and their ligands. Current Pharmaceutical Design 2002, 8:2353-2369.
    • (2002) Current Pharmaceutical Design , vol.8 , pp. 2353-2369
    • Müller, C.E.1
  • 177
    • 0029788548 scopus 로고    scopus 로고
    • Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: Identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor
    • Nicholas R.A., Watt W.C., Lazarowski E.R., Li Q., Harden K. Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: Identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. Molecular Pharmacology 1996, 50:224-229.
    • (1996) Molecular Pharmacology , vol.50 , pp. 224-229
    • Nicholas, R.A.1    Watt, W.C.2    Lazarowski, E.R.3    Li, Q.4    Harden, K.5
  • 179
    • 0038152846 scopus 로고    scopus 로고
    • Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family
    • Noguchi K., Ishii S., Shimizu T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. Journal of Biological Chemistry 2003, 278:25600-25606.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 25600-25606
    • Noguchi, K.1    Ishii, S.2    Shimizu, T.3
  • 181
    • 0036788971 scopus 로고    scopus 로고
    • Molecular physiology of P2X receptors
    • North R.A. Molecular physiology of P2X receptors. Physiological Reviews 2002, 82:1013-1067.
    • (2002) Physiological Reviews , vol.82 , pp. 1013-1067
    • North, R.A.1
  • 185
    • 47049130668 scopus 로고    scopus 로고
    • Crystal structure of the ligand-free G-protein-coupled receptor opsin
    • Park J.H., Scheerer P., Hofmann K.P., Choe H.W., Ernst O.P. Crystal structure of the ligand-free G-protein-coupled receptor opsin. Nature 2008, 454:183-187.
    • (2008) Nature , vol.454 , pp. 183-187
    • Park, J.H.1    Scheerer, P.2    Hofmann, K.P.3    Choe, H.W.4    Ernst, O.P.5
  • 189
    • 39749127777 scopus 로고    scopus 로고
    • G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
    • Pasternack S.M., von Kügelgen I., Aboud K.A., Lee Y.A., Rüschendorf F., Voss K., et al. G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nature Genetics 2008, 40:329-334.
    • (2008) Nature Genetics , vol.40 , pp. 329-334
    • Pasternack, S.M.1    von Kügelgen, I.2    Aboud, K.A.3    Lee, Y.A.4    Rüschendorf, F.5    Voss, K.6
  • 206
    • 18044378766 scopus 로고    scopus 로고
    • 12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis
    • 12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Seminars in Thrombosis and Hemostasis 2005, 31:174-183.
    • (2005) Seminars in Thrombosis and Hemostasis , vol.31 , pp. 174-183
    • Savi, P.1    Herbert, J.M.2
  • 212
    • 0024470467 scopus 로고
    • Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides
    • Seifert R., Schultz G. Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides. Trends in Pharmacological Sciences 1989, 10:365-369.
    • (1989) Trends in Pharmacological Sciences , vol.10 , pp. 365-369
    • Seifert, R.1    Schultz, G.2
  • 217
    • 47749117162 scopus 로고    scopus 로고
    • G protein betagamma subunits: Central mediators of G protein-coupled receptor signaling
    • Smrcka A.V. G protein betagamma subunits: Central mediators of G protein-coupled receptor signaling. Cellular and Molecular Life Sciences 2008, 65:2191-2214.
    • (2008) Cellular and Molecular Life Sciences , vol.65 , pp. 2191-2214
    • Smrcka, A.V.1
  • 223
    • 0034068625 scopus 로고    scopus 로고
    • The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties
    • Sugidachi A., Asai F., Ogawa T., Inoue T., Koike H. The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. British Journal of Pharmacology 2000, 129:1439-1446.
    • (2000) British Journal of Pharmacology , vol.129 , pp. 1439-1446
    • Sugidachi, A.1    Asai, F.2    Ogawa, T.3    Inoue, T.4    Koike, H.5
  • 226
    • 7444243225 scopus 로고    scopus 로고
    • Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye
    • Tauber J., Davitt W.F., Bokosky J.E., Nichols K.K., Yerxa B.R., Schaberg A.E., et al. Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye. Cornea 2004, 23:784-792.
    • (2004) Cornea , vol.23 , pp. 784-792
    • Tauber, J.1    Davitt, W.F.2    Bokosky, J.E.3    Nichols, K.K.4    Yerxa, B.R.5    Schaberg, A.E.6
  • 228
    • 0037040344 scopus 로고    scopus 로고
    • 11 receptors activate adenylyl cyclase and contribute to nucleotide-promoted cAMP formation in MDCK-D1 cells. A mechanism for nucleotide-mediated autocrine-paracrine regulation
    • 11 receptors activate adenylyl cyclase and contribute to nucleotide-promoted cAMP formation in MDCK-D1 cells. A mechanism for nucleotide-mediated autocrine-paracrine regulation. Journal of Biological Chemistry 2002, 277:7761-7765.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 7761-7765
    • Torres, B.1    Zambon, A.C.2    Insel, P.A.3
  • 233
    • 33646424353 scopus 로고    scopus 로고
    • Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
    • von Kügelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacology & Therapeutics 2006, 110:415-432.
    • (2006) Pharmacology & Therapeutics , vol.110 , pp. 415-432
    • von Kügelgen, I.1
  • 234
    • 0023640270 scopus 로고
    • Evidence for a vasoconstriction-mediating receptor for UTP, distinct from the P2 purinoceptor, in rabbit ear artery
    • von Kügelgen I., Häussinger D., Starke K. Evidence for a vasoconstriction-mediating receptor for UTP, distinct from the P2 purinoceptor, in rabbit ear artery. Naunyn-Schmiedeberg's Archives of Pharmacology 1987, 336:556-560.
    • (1987) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.336 , pp. 556-560
    • von Kügelgen, I.1    Häussinger, D.2    Starke, K.3
  • 249
  • 257
    • 0037137589 scopus 로고    scopus 로고
    • Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: Phosphate substitution leads to multiple pathways of inhibition of platelet aggregation
    • Xu B., Stephens A., Kirschenheuter G., Greslin A.F., Cheng X., Sennelo J., et al. Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: Phosphate substitution leads to multiple pathways of inhibition of platelet aggregation. Journal of Medicinal Chemistry 2002, 45:5694-5709.
    • (2002) Journal of Medicinal Chemistry , vol.45 , pp. 5694-5709
    • Xu, B.1    Stephens, A.2    Kirschenheuter, G.3    Greslin, A.F.4    Cheng, X.5    Sennelo, J.6
  • 260
    • 0035040885 scopus 로고    scopus 로고
    • Therapeutic use of nucleotides in respiratory and ophthalmic diseases
    • Yerxa B.R. Therapeutic use of nucleotides in respiratory and ophthalmic diseases. Drug Development Research 2001, 52:196-201.
    • (2001) Drug Development Research , vol.52 , pp. 196-201
    • Yerxa, B.R.1
  • 262
    • 0030976460 scopus 로고    scopus 로고
    • A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
    • Yokomizo T., Izumi T., Chang K., Takuwa Y., Shimizu T. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 1997, 387:620-624.
    • (1997) Nature , vol.387 , pp. 620-624
    • Yokomizo, T.1    Izumi, T.2    Chang, K.3    Takuwa, Y.4    Shimizu, T.5
  • 267
    • 41249099263 scopus 로고    scopus 로고
    • Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism
    • Zee R.Y., Michaud S.E., Diehl K.A., Chasman D.I., Emmerich J., Gaussem P., et al. Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism. Atherosclerosis 2008, 197:694-699.
    • (2008) Atherosclerosis , vol.197 , pp. 694-699
    • Zee, R.Y.1    Michaud, S.E.2    Diehl, K.A.3    Chasman, D.I.4    Emmerich, J.5    Gaussem, P.6
  • 271
    • 1642320995 scopus 로고    scopus 로고
    • 12 ADP receptor is essential for signal transduction but not for ligand binding or cell surface expression
    • 12 ADP receptor is essential for signal transduction but not for ligand binding or cell surface expression. FEBS Letters 2004, 562:111-117.
    • (2004) FEBS Letters , vol.562 , pp. 111-117
    • Zhong, X.1    Kriz, R.2    Seehra, J.3    Kumar, R.4
  • 272
    • 34447136067 scopus 로고    scopus 로고
    • 11 nucleotide receptor deduced from computational modelling and mutational analysis
    • 11 nucleotide receptor deduced from computational modelling and mutational analysis. Biochemical Journal 2007, 405:277-286.
    • (2007) Biochemical Journal , vol.405 , pp. 277-286
    • Zylberg, J.1    Ecke, D.2    Fischer, B.3    Reiser, G.4


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