2-chloro N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′, 5′-bisphosphate is a selective high affinity P2Y1 receptor antagonist

British Journal of Pharmacology

Volumn 135, Issue 8, 2002, Pages 2004-2010

  Boyer, José L ^a   Adams, Mary ^a   Ravi, R Gnana ^b   Jacobson, Kenneth A ^b   Harden, T Kendall ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Adenylyl cyclase; P2Y receptors; Phospholipase C; Platelet aggregation

Indexed keywords

1 [(PHOSPHATO)METHYL] 4 (2 CHLORO 6 METHYLAMINOPURIN 9 YL)BICYCLO[3.1.0]HEXANE 2 PHOSPHATE; ADENOSINE DIPHOSPHATE; ADENYLATE CYCLASE; CYCLIC AMP; DEOXYADENOSINE DERIVATIVE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; MRS 2279; PURINE P2Y RECEPTOR; PURINE P2Y1 RECEPTOR; PURINE P2Y11 RECEPTOR; PURINE P2Y2 RECEPTOR; PURINE P2Y4 RECEPTOR; PURINE P2Y6 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTOMA CELL; BINDING COMPETITION; BINDING KINETICS; DRUG SPECIFICITY; ERYTHROCYTE MEMBRANE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; TURKEY (BIRD);

ADENOSINE DIPHOSPHATE; ANIMALS; DEOXYADENINE NUCLEOTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INOSITOL PHOSPHATES; PLATELET AGGREGATION; RECEPTORS, PURINERGIC P2; TUMOR CELLS, CULTURED; TURKEYS;

EID: 0036245650     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704673     Document Type: Article

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