Structure-activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors

Purinergic Signalling

Volumn 1, Issue 2, 2005, Pages 183-191

  Shaver, Sammy R ^a   Rideout, Janet L ^a   Pendergast, William ^a   Douglass, James G ^a   Brown, Edward G ^a   Boyer, José L ^a   Patel, Roshni I ^a   Redick, Catherine C ^a   Jones, Arthur C ^a   Picher, Maryse ^b   Yerxa, Benjamin R ^a  

^a Inspire Pharmaceuticals   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Dinucleoside polyphosphates; IC50; Metabolic stability; P2Y receptors; Receptor selectivity; Synthesis of dinucleotides

Indexed keywords

AGONISTS; ARABINOCYTIDINE; CARBONYLDIIMIDAZOLE; DICYCLOHEXYLCARBODIIMIDE; DINUCLEOSIDE POLYPHOSPHATES; DINUCLEOTIDES; METABOLIC STABILITY; RECEPTOR SELECTIVITY; RECEPTORS; STRUCTURE-ACTIVITY RELATIONSHIPS;

DINUCLEOSIDE PHOSPHATE; DINUCLEOTIDE; NUCLEOSIDE; PHOSPHATE; PURINE P2Y RECEPTOR; PURINE P2Y2 RECEPTOR; PURINE P2Y6 RECEPTOR; PYRIMIDINE; URIDINE;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

EID: 20144387452     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-005-0648-2     Document Type: Article

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