Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease

BMC Medical Genetics

Volumn 8, Issue , 2007, Pages

  Cavallari, Ugo ^a   Trabetti, Elisabetta ^a   Malerba, Giovanni ^a   Biscuola, Michele ^a   Girelli, Domenico ^a   Olivieri, Oliviero ^a   Martinelli, Nicola ^a   Angiolillo, Dominick J ^b   Corrocher, Roberto ^a   Pignatti, Pier Franco ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN; PURINE P2Y12 RECEPTOR; TRIACYLGLYCEROL; P2RY12 PROTEIN, HUMAN; PURINE P2 RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ANGIOCARDIOGRAPHY; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; EPICARDIUM; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HEART CATHETERIZATION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; RISK FACTOR; SMOKING; STENOSIS; THROMBOCYTE ACTIVATION; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; CASE CONTROL STUDY; CORONARY ARTERY ATHEROSCLEROSIS; GENETICS; MIDDLE AGED; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; CASE-CONTROL STUDIES; CORONARY ARTERIOSCLEROSIS; FEMALE; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, PURINERGIC P2; VARIATION (GENETICS);

EID: 35748969344     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-8-59     Document Type: Article

References (21)

1. Ruggeri ZM: Platelets in Atherothrombosis. Nat Med 2002, 8: 1227-1234 10.1038/nm1102-1227 12411949
2. Huo Y Ley KF Role of platelets in the development of atherosclerosis Trends Cardiovasc Med 2004; 14:18-22 10.1016/j.tcm.2003.09.007 14720470
3. Wang TH Bhatt DL Topol EJ Aspirin and clopidogrel resistance: An emerging clinical entity. Eur Heart J 2006, 27:647-54 10.1093/eurheartj/ ehi684 16364973
4. Hollopeter G Jantzen HM Vincent D Li G England L Ramakrishnan V Yang RB Nurden P Nurden A Julius D Conley PB Identification of the platelet ADP receptor targeted by antithrombotic drugs Nature 2001,409:202-207 10.1038/35051599 11196645
5. Yusuf S Zhao F Mehta SR Chrolavicius S Tognoni G Fox KK Clopidogrel in unstable angina to prevent recurrent events trial investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation N Engl J Med 2001,345:494-502 10.1056/NEJMoa010746 11519503
6. CAPRIE Steering Committee A randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE) Lancet 1996,348:1329-1339 10.1016/S0140-6736(96)09457-3 8918275
7. Fontana P Dupont A Gandrille S Bachelot-Loza C Reny JL Aiach M Gaussem P Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects Circulation 2003,108:989-995 10.1161/01.CIR.0000085073.69189.88 12912815
8. Fontana P Gaussem P Aiach M Fiessinger JN Emmerich J Reny JL P2Y12 H2 haplotype is associated with peripheral arterial disease. A case-control study. Circulation 2003,108: 2971-2973 10.1161/ 01.CIR.0000106904.80795.35 14662702
9. Girelli D Friso S Trabetti E Olivieri O Russo C Pessotto R Faccini G Pignatti PF Mazzucco A Corrocher R Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: Evidence for an important genetic-environmental interaction. Blood 1998, 91:4158-4163 9596662
10. Martinelli N Girelli D Olivieri O Stranieri C Trabetti E Pizzolo F Friso S Tenuti I Cheng S Grow MA Pignatti PF Corrocher R Interaction between smoking and PON2 Ser311Cys polymorphism as a determinant of the risk of myocardial infarction. Eur J Clin Invest 2004, 34: 14-20 10.1111/ j.1365-2362.2004.01292.x 14984433
11. R Development Core Team R A language and environment for statistical computing R Foundation for Statistical Computing, Vienna, Austria 2006 ISBN 3-900051-07-0
12. The International HapMap Consortium The International HapMap Project. Nature 2003,426: 789-796 10.1038/nature02168 14685227
13. Schettert IT Pereira AC Lopes NH Hueb WA Krieger JE Association between platelet P2Y12 haplotype and risk of cardiovascular events in chronic coronary disease Thromb Res 2006, 118:679-683 10.1016/ j.thromres.2005.11.009 16405973
14. Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramirez C, Cavallari U, Trabetti E, Sabate M, Jimenez-Quevedo P, Hernandez R, Moreno R, Escaned J, Alfonso F, Banuelos C, Costa MA, Bass TA, Pignatti PF, Macaya C, Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease Thromb Res 2005, 116:491-497 10.1016/j.thromres.2005.03.001 16181985
15. von Beckerath N von Beckerath O Koch W Eichinger M Schomig A Kastrati A P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose Blood Coagul Fibrinolysis 2005, 16:199-204 10.1097/01.mbc.0000164429.21040.0a 15795539
16. Lev EI Patel RT Guthikonda S Lopez D Bray PF Kleiman NS Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel Thromb Res 2007, 119:355-60 10.1016/ j.thromres.2006.02.006 16581111
17. Smith SM Judge HM Peters G Armstrong M Fontana P Gaussem P Daly ME Storey RF, Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy Platelets 2006, 17: 250-8 10.1080/09537100500475844 16769602
18. Angiolillo DJ Fernandez-Ortiz A Bernardo E Ramirez C Cavallari U Trabetti E Sabate M Hernandez R Moreno R Escaned J Alfonso F Banuelos C Costa MA Bass TA Pignatti PF Macaya C Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel Arterioscler Thromb Vasc Biol 2006, 26:(8)1895-900 10.1161/01.ATV.0000223867.25324.1a 16645157
19. Hetherington SL Singh RK Lodwick D Thompson JR Goodall AH Samani NJ Dimorphism in the P2Y1 ADP Receptor Gene is associated with increased platelet activation response to ADP Arterioscler Thromb Vasc Biol 2005, 25:252-257 15514209
20. Ambrose JA Barua RS The pathophysiology of cigarette smoking and cardiovascular disease. An update J Am Coll Cardiol 2004, 43:1731-1737 10.1016/j.jacc.2003.12.047 15145091
21. Shanker G Kontos JL Eckman DM Wesley-Farrington D Sane DC Nicotine upregulates the expression of P2Y12 on vascular cells and megakaryoblasts J Thromb Thrombolysis 2006, 22:213-220 10.1007/ s11239-006-9033-4 17111196