Synthesis of uracil nucleotide analogs with a modified, acyclic ribose moiety as P2Y2 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5071-5079

  Sauer, Roland ^a   El Tayeb, Ali ^a   Kaulich, Marko ^a   Müller, Christa E ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Acyclic ribose modification; Nucleotide analogs; P2Y2 receptors; Phosphonates; UTP, UDP, UMP analogs

Indexed keywords

1,3 DIOXANE DERIVATIVE; 1,3 DIOXOLANE; 5 (2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1(2H) YL)PENTYLPHOSPHONIC ANHYDRIDE; ALKYL GROUP; OXYGEN; PHOSPHORUS DERIVATIVE; PHOSPHORUS OXYCHLORIDE; PURINERGIC P2Y2 RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; RIBOSE; SODIUM HYDROXIDE; TRIETHYL PHOSPHITE; TRIMETHYLSILYL BROMIDE; TRIMETHYLSILYL DERIVATIVE; TRIMETHYLSILYL IODIDE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANIMAL CELL; ARTICLE; DEPROTECTION REACTION; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; HYDROLYSIS; IC 50; MOUSE; NONHUMAN; PHOSPHORYLATION; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; CELL LINE, TUMOR; HYBRID CELLS; MICE; NUCLEOTIDES; PHOSPHONIC ACIDS; RATS; RECEPTORS, PURINERGIC P2; URACIL;

EID: 67650091783     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.062     Document Type: Article

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