Polarized expression of human P2Y receptors in epithelial cells from kidney, lung, and colon

American Journal of Physiology - Cell Physiology

Volumn 288, Issue 3 57-3, 2005, Pages

  Wolff, Samuel C ^a,b   Qi, Ai Dong ^a   Harden, T Kendall ^a,b   Nicholas, Robert A ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

16HBE14o ; Caco 2; Confocal microscopy; Madin Darby canine kidney; Polarized targeting

Indexed keywords

ADENINE NUCLEOTIDE; CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; PURINE P2Y RECEPTOR;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; BIOTINYLATION; CALCIUM TRANSPORT; CELL FUNCTION; CELL MEMBRANE; CELL STRAIN CACO 2; COLON MUCOSA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOG; EPITHELIUM CELL; HUMAN; HUMAN CELL; KIDNEY EPITHELIUM; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ANIMALS; CACO-2 CELLS; CALCIUM; CELL POLARITY; COLON; DOGS; EPITHELIAL CELLS; HUMANS; KIDNEY; LUNG; MICROSCOPY, CONFOCAL; NUCLEOTIDES; PROTEIN ISOFORMS; PROTEIN SORTING SIGNALS; RECEPTORS, PURINERGIC P2;

EID: 13644263173     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00338.2004     Document Type: Article

References (46)

1. 2-adrenergic receptors in the lung epithelial cell lines 16HBE14o-, Calu-3 and A549. Biochim Biophys Acta 1691: 169-179, 2004.
2. 6-methyl 2′-deoxyadenosine 3′,5′-bisphosphate. Br J Pharmacol 124: 1-3, 1998.
3. Chambers JK, Macdonald LE, Sarau HM, Ames RS, Freeman K, Foley JJ, Zhu Y, McLaughlin MM, Murdock P, McMillan L, Trill J, Swift A, Aiyar N, Taylor P, Vawter L, Naheed S, Szekeres P, Hervieu G, Scott C, Watson JM, Murphy AJ, Duzic E, Klein C, Bergsma DJ, Wilson S, and Livi GP. A G protein-coupled receptor for UDP-glucose. J Biol Chem 275: 10767-10771, 2000.
4. i. J Biol Chem 276: 41479-41485, 2001.
5. Communi D, Govaerts C, Parmentier M, and Boeynaems JM. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. J Biol Chem 272: 31969-31973, 1997.
6. Comstock KE, Watson NF, and Olsen JC. Design of retroviral expression vectors. In: Methods in Molecular Biology: Recombinant Gene Expression Protocols, edited by Tuan R. Totowa, NJ: Humana, 1997, vol. 62, p. 207-222.
7. Cozens AL, Yezzi MJ, Kunzelmann K, Ohrui T, Chin L, Eng K, Finkbeiner WE, Widdicombe JH, and Gruenert DC. CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol 10: 38-47, 1994.
8. - transport. J Biol Chem 274: 26461-26468, 1999.
9. Dranoff JA, Masyuk AI, Kruglov EA, LaRusso NF, and Nathanson MH. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Am J Physiol Gastrointest Liver Physiol 281: G1059-G1067, 2001.
10. Dubyak GR. Knock-out mice reveal tissue-specific roles of P2Y receptor subtypes in different epithelia. Mol Pharmacol 63: 773-776, 2003.
11. Fogh J, Fogh JM, and Orfeo T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J Natl Cancer Inst 59: 221-226, 1977.
12. Folsch H, Ohno H, Bonifacino JS, and Mellman I. A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. Cell 99: 189-198, 1999.
13. Forbes II. Human airway epithelial cell lines for in vitro drug transport and metabolism studies. Pharm Sci Technol Today 3: 18-27, 2000.
14. Harden TK. The G-protein-coupled P2Y receptors. In: Cardiovascular Biology of Purines, edited by Burnstock G, Dobson JGJ, Liang BT, and Linden J. London: Kluwer Academic, 1998, p. 181-205.
15. Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, Julius D, and Conley PB. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409: 202-207, 2001.
16. Homolya L, Steinberg TH, and Boucher RC. Cell to cell communication in response to mechanical stress via bilateral release of ATP and UTP in polarized epithelia. J Cell Biol 150: 1349-1360, 2000.
17. 2 receptor (-/-) mice. J Biol Chem 274: 26454-26460, 1999.
18. Insel PA, Ostrom RS, Zambon AC, Hughes RJ, Balboa MA, Shehnaz D, Gregorian C, Torres B, Firestein BL, Xing M, and Post SR. P2Y receptors of MDCK cells: epithelial cell regulation by extracellular nucleotides. Clin Exp Pharmacol Physiol 28: 351-354, 2001.
19. Joseph SM, Pifer MA, Przybylski RJ, and Dubyak GR. Methylene ATP analogs as modulators of extracellular ATP metabolism and accumulation. Br J Pharmacol 142: 1002-1014, 2004.
20. 2A-adrenergic receptor is targeted directly to the basolateral membrane domain of Madin-Darby canine kidney cells independent of coupling to pertussis toxin-sensitive GTP-binding proteins. J Biol Chem 268: 11340-11347, 1993.
21. Kenakin T. Pharmacologic Analysis of Drug-Receptor Interaction. Philadelphia, PA: Lippincott-Raven, 1997.
22. Lazarowski ER, Boucher RC, and Harden TK. Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol Pharmacol 64: 785-795, 2003.
23. Lazarowski ER and Harden TK. Quantitation of extracellular UTP using a sensitive enzymatic assay. Br J Pharmacol 127: 1272-1278, 1999.
24. Lazarowski ER, Homolya L, Boucher RC, and Harden TK. Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation. J Biol Chem 272: 24348-24354, 1997.
25. 2 receptor. Proc Natl Acad Sci USA 94: 2599-2603, 1997.
26. Leipziger J. Control of epithelial transport via luminal P2 receptors. Am J Physiol Renal Physiol 284: F419-F432, 2003.
27. + secretion by vestibular dark cell epithelium. Am J Physiol Cell Physiol 281: C282-C289, 2001.
28. Mason SJ, Paradiso AM, and Boucher RC. Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium. Br J Pharmacol 103: 1649-1656, 1991.
29. McAlroy HL, Ahmed S, Day SM, Baines DL, Wong HY, Yip CY, Ko WH, Wilson SM, and Collett A. Multiple P2Y receptor subtypes in the apical membranes of polarized epithelial cells. Br J Pharmacol 131: 1651-1658, 2000.
30. Mostov KE, Verges M, and Altschuler Y. Membrane traffic in polarized epithelial cells. Curr Opin Cell Biol 12: 483-490, 2000.
31. Nadler LS, Kumar G, and Nathanson NM. Identification of a basolateral sorting signal for the M3 muscarinic acetylcholine receptor in Madin-Darby canine kidney cells. J Biol Chem 276: 10539-10547, 2001.
32. Paradiso AM, Ribeiro CM, and Boucher RC. Polarized signaling via purinoceptors in normal and cystic fibrosis airway epithelia. J Gen Physiol 117: 53-67, 2001.
33. Post SR, Jacobson JP, and Insel PA. P2 purinergic receptor agonists enhance cAMP production in Madin-Darby canine kidney epithelial cells via an autocrine/paracrine mechanism. J Biol Chem 271: 2029-2032, 1996.
34. Post SR, Rump LC, Zambon A, Hughes RJ, Buda MD, Jacobson JP, Kao CC, and Insel PA. ATP activates cAMP production via multiple purinergic receptors in MDCK-D1 epithelial cells. Blockade of an autocrine/paracrine pathway to define receptor preference of an agonist. J Biol Chem 273: 23093-23097, 1998.
35. 11 receptor to phospholipase C and adenylyl cyclase. Br J Pharmacol 132: 318-326, 2001.
36. Ralevic V and Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 50: 413-492, 1998.
37. Reddel RR, Ke Y, Gerwin BI, McMenamin MG, Lechner JF, Su RT, Brash DE, Park JB, Rhim JS, and Harris CC. Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res 48: 1904-1909, 1988.
38. 4-null mice. Mol Pharmacol 63: 777-783, 2003.
39. 2 purinergic receptors in strial marginal cells and vestibular dark cells. J Membr Biol 185: 103-115, 2002.
40. 11 receptors activate adenylyl cyclase and contribute to nucleotide-promoted cAMP formation in MDCK-D1 cells. A mechanism for nucleotide-mediated autocrine-paracrine regulation. J Biol Chem 277: 7761-7765, 2002.
41. i receptor with a high affinity radiolabeled antagonist. Mol Pharmacol 62: 1249-1257, 2002.
42. 2+ signaling mediated by P2Y receptors in polarized epithelia. J Biol Chem 277: 9016-9021, 2002.
43. Yeaman C, Grindstaff KK, and Nelson WJ. New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol Rev 79: 73-98, 1999.
44. 11 receptors in Madin Darby canine kidney cells. Mol Pharmacol 60: 26-35, 2001.
45. 2 receptor of MDCK cells: cloning, expression, and cell-specific signaling. Am J Physiol Renal Physiol 279: F1045-F1052, 2000.
46. i-coupled ADP receptor from human and mouse. J Pharmacol Exp Ther 301: 705-713, 2002.