Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 4, 2003, Pages 1978-1983

  Cattaneo, Marco ^a,b   Zighetti, Maddalena L ^a   Lombardi, Rossana ^a   Martinez, Constantino ^b   Lecchi, Anna ^a   Conley, Pamela B ^c   Ware, Jerry ^b   Ruggeri, Zaverio M ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

ADP; G protein coupled receptors; Platelet aggregation; Platelet function disorder

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENYLATE CYCLASE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; PROSTAGLANDIN E1; PURINE P2Y RECEPTOR; PURINE P2Y12 RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLEEDING DISORDER; CASE REPORT; ENZYME ACTIVITY; HUMAN; MALE; MOLECULAR BIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION;

ADULT; ALPROSTADIL; BASE SEQUENCE; BLOOD PLATELETS; CALCIUM; CYCLIC AMP; DNA PRIMERS; FEMALE; HEMORRHAGE; HETEROZYGOTE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION;

EID: 0037452681     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0437879100     Document Type: Article

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