Synthesis, biological activity, and molecular modeling of ribose- modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands

Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2000, Pages 829-842

  Nandanan, Erathodiyil ^a   Jang, Soo Yeon ^a   Moro, Stefano ^e   Kim, Hea Ok ^f   Siddiqui, Maqbool A ^c   Russ, Pamela ^c   Marquez, Victor E ^c   Busson, Roger ^d   Herdewijn, Piet ^d   Harden, T Kendall ^b   Boyer, José L ^b   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^e UNIVERSITY OF PADOVA   (Italy)

^f Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; DEOXYADENOSINE DERIVATIVE; PURINE P2Y RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; RIBOSE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; MOLECULAR MODEL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; DEOXYADENINE NUCLEOTIDES; ENZYME ACTIVATION; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; INOSITOL PHOSPHATES; LIGANDS; MODELS, MOLECULAR; PHOSPHOLIPASE C; RECEPTORS, PURINERGIC P2; RIBOSE; STRUCTURE-ACTIVITY RELATIONSHIP; TURKEYS;

EID: 0034624785     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990249v     Document Type: Article

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