Identification of the platelet ADP receptor targeted by antithrombotic drugs

Nature

Volumn 409, Issue 6817, 2001, Pages 202-207

  Hollopeter, Gunther ^a   Jantzen, Hans Michael ^b   Vincent, Diana ^b   Li, Georgia ^b,c   England, Laura ^a,d   Ramakrishnan, Vanitha ^b   Yang, Ruey Bing ^b   Nurden, Paquita ^e   Nurden, Alan ^e   Julius, David ^a   Conley, Pamela B ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c Advanced Medicine Inc   (United States)

^d FIBROGEN INC   (United States)

^e HAUT LÉVÊQUE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENYLATE CYCLASE; ANTICOAGULANT AGENT; CALCIUM ION; CLOPIDOGREL; FIBRINOGEN; FIBRINOGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; THROMBOCYTE RECEPTOR; TICLOPIDINE;

ANIMAL CELL; ARTICLE; BLEEDING DISORDER; BLOOD VESSEL OCCLUSION; CALCIUM CELL LEVEL; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; ENZYME INHIBITION; GENETIC DISORDER; HEART INFARCTION; HEMOSTASIS; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; STROKE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTE SHAPE; THROMBOGENESIS; UNSTABLE ANGINA PECTORIS;

ADENOSINE DIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; BLOOD PLATELETS; BRAIN; CHO CELLS; CHROMOSOMES, HUMAN, PAIR 3; CLONING, MOLECULAR; CRICETINAE; CYCLIC AMP; DNA, COMPLEMENTARY; FEMALE; FIBRINOLYTIC AGENTS; FRAMESHIFT MUTATION; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GTP-BINDING PROTEINS; HEMORRHAGE; HUMANS; MALE; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; OOCYTES; PLATELET AGGREGATION; POTASSIUM; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RECEPTORS, PURINERGIC P2; TISSUE DISTRIBUTION; XENOPUS;

ANGINA; ANIMALIA; THROMBUS;

EID: 0035843178     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35051599     Document Type: Article

References (28)

1. ADP receptors on platelets
2. Evidence for two distinct G-protein-coupled ADP receptors mediating platelet activation
3. Molecular basis for ADP-induced platelet activation. 1. Evidence for three distinct ADP receptors on human platelets
4. 1 receptor-null mice
5. 1-deficient mice
6. 1
7. ADP receptor induced activation of guanine nucleotide binding proteins in rat platelet membranes - An effect selectively blocked by the thienopyridine clopidogrel
8. Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclase Arterioscler
9. 2T-purinoreceptors
10. An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets
11. + channel, IKACh
12. i2 proteins
13. 32P]diphosphate: An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets
14. Receptors for ADP on human blood platelets
15. Evidence for two distinct G protein-coupled ADP receptors mediating platelet activation
16. 1 receptor
17. 1 receptor
18. 2+ channel in neurones, with both adenosine triphosphates and diphosphates as potent agonists
19. Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase
20. An STS-based radiation hybrid map of the human genome
21. A G protein-coupled receptor for UDP-glucose
22. Identification and biological activity of the active metabolite of Clopidogrel
23. ADP receptors and clinical bleeding disorders
24. ADP can induce aggregation of human platelets via both P2Y(1) and P(2T) receptors
25. 1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug dopidogrel
26. Ultrastructural studies of platelet aggregates from human subjects receiving clopidogrel and from a patient with an inherited defect of an ADP-dependent pathway of platelet activation
27. Thrombotic thrombocytopenic purpura associated with clopldogrel
28. The capsaicin receptor: A heat-activated ion channel in the pain pathway