Carba-nucleosides as potent antagonists of the adenosine 5′-diphosphate (ADP) purinergic receptor (P2Y12) on human platelets

ChemMedChem

Volumn 3, Issue 5, 2008, Pages 732-736

  Ye, Hong ^a   Chen, Cailin ^a   Zhang, Han Cheng ^a   Haertlein, Barbara ^a   Parry, Tom J ^a   Damiano, Bruce P ^a   Maryanoff, Bruce E ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

ADP receptor; Antagonist; Nucleosides; P2Y12 receptor; Platelet; Purinergic

Indexed keywords

CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; NUCLEOSIDE; PURINERGIC P2 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; TETRAZOLE DERIVATIVE;

ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SYNTHESIS; THROMBOCYTE; THROMBOCYTE AGGREGATION;

BLOOD PLATELETS; CALCIUM; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; NUCLEOSIDES; PLATELET AGGREGATION; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; TETRAZOLES;

EID: 47649131393     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200700310     Document Type: Article

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