Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: Phosphate substitution leads to multiple pathways of inhibition of platelet aggregation

Journal of Medicinal Chemistry

Volumn 45, Issue 26, 2002, Pages 5694-5709

  Xu, Bin ^a   Stephens, Andrew ^b   Kirschenheuter, Gary ^b   Greslin, Arthur F ^b   Cheng, Xiaoquin ^b   Sennelo, Joe ^b   Cattaneo, Marco ^c   Zighetti, Maddalena L ^c   Chen, Aishe ^a   Kim, Soon Ai ^a   Kim, Hak Sung ^a   Bischofberger, Norbert ^b   Cook, Gary ^b   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b GILEAD SCIENCES   (United States)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE BISPHOSPHONATE; ADENOSINE DIPHOSPHATE; BISPHOSPHONIC ACID DERIVATIVE; PHOSPHOLIPASE C; PURINE P2Y RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; ENZYME ACTIVITY; RECEPTOR BINDING; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION;

ADENOSINE DIPHOSPHATE; ANIMALS; BLOOD PLATELETS; CELL LINE; CYCLIC AMP; HUMANS; INOSITOL PHOSPHATES; NUCLEOSIDES; PHOSPHOLIPASE C; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037137589     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020173u     Document Type: Article

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