Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y1 receptor-null mice

Journal of Clinical Investigation

Volumn 104, Issue 12, 1999, Pages 1731-1737

  Léon, Catherine ^a   Hechler, Béatrice ^a   Freund, Monique ^a   Eckly, Anita ^a   Vial, Catherine ^a   Ohlmann, Philippe ^a   Dierich, Andrée ^b   LeMeur, Marianne ^b   Cazenave, Jean Pierre ^a   Gachet, Christian ^a  

^a INSERM   (France)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENYLATE CYCLASE; PURINE P2Y RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE DISRUPTION; GENETIC RECOMBINATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR GENE; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE SHAPE; THROMBOSIS;

EID: 0342723744     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8399     Document Type: Article

References (41)

1. Gaarder, A., Jonsen, J., Laland, S., Hellem, A., and Owren, P.A. 1961. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets. Nature. 192:531-532.
2. Born, G.V.R. 1962. Platelet aggregation and its reversal. Nature. 194:927-929.
3. Mills, D.C. 1997. ADP receptors on platelets. Thromb. Haemost. 76:835-856.
4. Webb, T.E., et al. 1993. Cloning and functional expression of a brain G-protein-coupled ATP receptor. FEBS Lett. 324:219-225.
5. 1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. FEBS Lett. 403:26-30.
6. 1 receptor: similarities to the platelet ADP receptor. Mol. Pharmacol. 53:727-733.
7. Ralevic, V., and Burnstock, G. 1998. Receptors for purines and pyrimidines. Pharmacol. Rev. 50:413-492.
8. 1 receptor. Mol. Pharmacol. 50:1323-1329.
9. 1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J. Biol. Chem. 273:2030-2034.
10. 1 purinoceptor in ADP-induced platelet activation. FEBS Lett. 422:291-295.
11. 1 receptor is necessary for ADP-induced platelet aggregation. Blood. 92:152-159.
12. Humphries, R.G., Tomlinson, W., Ingall, A.G., Cage, P.A., and Leff, P. 1994. FPL 66096LT: a novel, highly potent and selective antagonist at human platelet P2T-receptors. Br. J. Pharmacol. 113:1057-1063.
13. 1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel. Br. J. Haematol. 103:858-866.
14. Daniel, J.L., et al. 1998. Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets. J. Biol. Chem. 273:2024-2029.
15. ADP-receptors. Br. J. Pharmacol. 124:157-164.
16. Geiger, J., Hönig-Liedl, P., Schanzenbächer, P., and Walter, U. 1998. Ligand specificity and ticlopidine effects distinguish three human platelet ADP receptors. Eur. J. Pharmacol. 351:235-246.
17. Geiger, J., et al. 1999. Specific impairment of human platelet P2Y(AC) ADP receptor-mediated signaling by the antiplatelet drug clopidogrel. Arterioscler. Thromb. Vasc. Biol. 19:2007-2011.
18. Jantzen, H.-M., et al. 1999. Evidence for two distinct G-protein-coupled ADP receptors mediating platelet activation. Thromb. Haemost. 81:111-117.
19. Cattaneo, M., Lecchi, A., Randi, A.M., McGregor, J.L., and Mannuci, P.M. 1992. Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphare. Blood. 80:2787-2796.
20. Nurden, P., et al. 1995. An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. J. Clin. Invest. 95:1612-1622.
21. 1 receptor is normal in a patient presenting a severe deficiency of ADP-induced plarelet aggregation. Thromb. Haemost. 81:775-781.
22. 2 proteins. Biochem. J. 312:775-779.
23. Jin, J., and Kunapuli, S.P. 1998. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc. Natl. Acad. Sci. USA. 95:8070-8074.
24. 1 not P2T purinoceptors in human platelets. J. Biol. Chem. 271:2879-2881.
25. 1 purinoceptors in human platelets and megakaryoblastic cell lines. Thromb. Haemost. 78:1500-1504.
26. 1 purinoceptor expressed on human platelets. Biochem. Biophys. Res. Commun. 242:525-528.
27. 1 purinoceptor in human platelets. Molecular cloning and functional characterization after heterologous expression. J. Biol. Chem. 273:11544-11547.
28. 1 receptor an adenosine triphosphate-gated cation channel, is expressed in human platelets but not in human blood leukocytes. Blood. 91:3172-3181.
29. Takano, S., Kimura, J., Matsuoka, I., and Ono, T. 1999. No requirement of P2X1 purinoceptors for platelet aggregation. Eur. J. Pharmacol. 372:305-309.
30. Tokuyama, Y., Hara, M., Jones, E.M., Fan, Z., and Bell, G.I. 1995. Cloning of rat and mouse P2Y purinoceptors. Biochem. Biophys. Res. Commun. 211:211-218.
31. Lufkin, T., Dierich, A., LeMeur, M., Mark, M., and Chambon, P. 1991. Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell. 66:1105-1119.
32. Lanza, F., et al. 1998. Epinephrine potentiates human platelet activation but is not an aggregating agent. Am. J. Physiol. 255:1276-1288.
33. DiMinno, G., and Silver, M.J. 1983. Mouse antithrombotic assay: a simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by ethyl alcohol. J. Pharmacol. Exp. Ther. 255:57-60.
34. 1 suggests a role for nucleotide signalling in development of the chick embryo. Dev. Dyn. 214:152-158.
35. Webb, T.E., et al. 1996. The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase. Br. J. Pharmacol. 119:1385-1392.
36. Moroi, M., and Jung, S.M. 1997. Platelet receptors for collagen. Thromb. Haemost. 78:439-444.
37. Watson, S.P., and Gibbins, J. 1998. Collagen receptor signalling in platelets: extending the role of the ITAM. Immunol. Today. 19:260-264.
38. Savage, B., Almus-Jacobs, F., and Ruggeri, Z.M. 1998. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell. 94:657-666.
39. Hong, M.K., Mehran, R., Mintz, G.S., and Leon, M.B. 1997. Restenosis after coronary angioplasty. Curr. Probl. Cardiol. 22:1-36.
40. Robson, S.C., et al. 1997. Loss of ATP diphosphohydrolase activity with endothelial cell activation. J. Exp. Med. 185:153-163.
41. Enjyoji, K., et al. 1999. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat. Med. 5:1010-1017.