Differential coupling of the human P2Y11 receptor to phospholipase C and adenylyl cyclase

British Journal of Pharmacology

Volumn 132, Issue 1, 2001, Pages 318-326

  Qi, Ai Dong ^a   Kennedy, Charles ^b   Harden, T Kendall ^a   Nicholas, Robert A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

ATP; Cyclic AMP; Inositol phosphates; P2Y receptors; Protein kinase C

Indexed keywords

ADENINE NUCLEOTIDE DERIVATIVE; ADENOSINE DERIVATIVE; ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; CYCLIC AMP; DOPAMINE 1 RECEPTOR; INOSITOL PHOSPHATE; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE INHIBITOR; PHOSPHOLIPASE C; PROTEIN KINASE C; PURINE P2Y RECEPTOR;

ANIMAL CELL; ARTICLE; ASTROCYTOMA CELL; CALCIUM MOBILIZATION; CELL LINE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYDROLYSIS; LIPOLYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SECOND MESSENGER;

EID: 0035143199     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703788     Document Type: Article

References (46)

1. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium
2. Activation of a metabotropic excitatory amino acid receptor potentiates A2b adenosine receptor-stimulated cyclic AMP accumulation
3. Molecular tinkering of G proteincoupled receptors: An evolutionary success
4. A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates
5. Molecular cloning and expression of an avian G protein-coupled p2y receptor
6. 3H]NECA in rat striatal membranes
7. Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: Comparison with caffeine and 7-(2-chloroethyl) theophylline
8. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase
9. 4 receptor
10. Cloning, functional expression and tissue distribution of the human P2Y6 receptor
11. 11 receptor
12. Design of retroviral expression vectors
13. Adenylyl cyclases and the interaction between calcium and cAMP signalling
14. Kinetic studies on the mechanism by which histamine HI receptors potentiate cyclic AMP accumulation in guinea pig cerebral cortical slices
15. 2+ mobilization
16. The G-Protein-coupled P2Y receptors
17. Differential modification of the interaction of the cardiac muscarinic cholinergic and beta-adrenergic receptors with a guanine nucleotide binding component
18. Effects of protein kinase inhibitor (1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) on protein kinase C activity and adrenergic stimulation of cAMP and cGMP in rat pinealocytes
19. Isoforms of the rat calcitonin receptor: Consequences for ligand binding and signal transduction
20. 2-purinoceptor in cultured CHO-K1 cells
21. 4 receptor
22. 11 receptor to phospholipase C and adenylyl cyclase
23. Metabotropic receptors for ATP and UTP: Exploring the correspondence between native and recombinant nucleotide receptors
24. Potentiation of receptor-mediated cAMP production: Role in the cross-talk between vasopressin V1a and V2 receptor transduction pathways
25. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes
26. Pharmacological selectivity of the cloned human P2U-purinoceptor: Potent activation by diadenosine tetraphosphate
27. 1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells
28. 6 receptor is the nearest mammalian homologue of the avian p2y3 receptor
29. Expression cloning of an ATP receptor from mouse neuroblastoma cells
30. Tunicamycin treatment of CHO cells abrogates multiple blocks to retrovirus infection, one of which is due to a secreted inhibitor
31. Inhibitors of retrovirus infection are secreted by several hamster cell lines and are also present in hamster sera
32. Improved retroviral vectors for gene transfer and expression
33. Direct linkage of three tachykinin receptors to stimulation of both phosphatidylinositol hydrolysis and cyclic AMP cascades in transfected chinese hamster ovary cells
34. Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: Identification of a UDPselective, a UTP-selective, and an ATP- and UTP-specific receptor
35. Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene
36. Nucleotide receptors
37. G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells
38. 1 receptor
39. Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase
40. 1-purinergic receptor
41. Differential signal transduction by five splice variants of the PACAP receptor
42. 11 receptor-mediated signalling to phospholipase C and adenylyl cyclase by protein kinase C in HL-60 promyelocytes
43. Catalytic mechanism and regulation of mammalian adenylyl cyclases
44. 1 adenosine receptors
45. 2 cascades in CHO cells expressing the human cDNA of TSH receptor