Human P2Y1 receptor: Molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites

Journal of Medicinal Chemistry

Volumn 41, Issue 9, 1998, Pages 1456-1466

  Moro, Stefano ^a   Guo, Danping ^a   Camaioni, Emidio ^a   Boyer, José L ^b   Kendall Harden, T ^b   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; 2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; 6 N METHYLADENOSINE; ADENOSINE DERIVATIVE; ALANINE; BISPHOSPHONIC ACID DERIVATIVE; MUTANT PROTEIN; PURINE P2Y RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE; DRUG DERIVATIVE; ENZYME INHIBITOR; LIGAND; N(6) METHYL 2' DEOXYADENOSINE 3',5' DIPHOSPHATE; N(6)-METHYL-2'-DEOXYADENOSINE 3',5'-DIPHOSPHATE; PHOSPHOLIPASE C; PURINE P2 RECEPTOR; PURINE P2Y1 RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BLOOD VESSEL REACTIVITY; DRUG POTENCY; DRUG STRUCTURE; MOLECULAR MODEL; MONKEY; NEUROENDOCRINE SYSTEM; NONHUMAN; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS; SMOOTH MUSCLE CONTRACTILITY; ANIMAL; CELL STRAIN COS1; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG POTENTIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE;

ADENOSINE DIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; COS CELLS; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHOLIPASE C; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, PURINERGIC P2;

EID: 0032559887     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970684u     Document Type: Article

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