Architecture of P2Y nucleotide receptors: Structural comparison based on sequence analysis, mutagenesis, and homology modeling

Journal of Medicinal Chemistry

Volumn 47, Issue 22, 2004, Pages 5393-5404

  Costanzi, Stefano ^a   Mamedova, Liaman ^a   Gao, Zhan Guo ^a   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLTHIOADENOSINE DIPHOSPHATE; 2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; ADENINE NUCLEOTIDE; ALANINE; G PROTEIN COUPLED RECEPTOR; PHENYLALANINE; PURINE P2Y RECEPTOR; PURINE P2Y1 RECEPTOR; PURINE P2Y12 RECEPTOR; PURINERGIC RECEPTOR AFFECTING AGENT; PURINERGIC RECEPTOR BLOCKING AGENT; RHODOPSIN; TYROSINE; UNCLASSIFIED DRUG; URACIL;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CATTLE; COMPARATIVE STUDY; DELETION MUTANT; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR RECOGNITION; MUTAGENESIS; MUTATION; NONHUMAN; PHYLOGENY; PROTEIN DOMAIN; RECEPTOR UPREGULATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; COS CELLS; HUMANS; HYDROGEN BONDING; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; RADIOLIGAND ASSAY; RECEPTORS, PURINERGIC P2; RHODOPSIN; SEQUENCE ALIGNMENT;

EID: 6044234752     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049914c     Document Type: Article

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