Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor

Biochemical Pharmacology

Volumn 68, Issue 10, 2004, Pages 1995-2002

  Cattaneo, Marco ^a,b   Lecchi, Anna ^b   Ohno, Michihiro ^c   Joshi, Bhalchandra V ^c   Besada, Pedro ^c   Tchilibon, Susanna ^c   Lombardi, Rossana ^b   Bischofberger, Norbert ^d   Harden, T Kendall ^e   Jacobson, Kenneth A ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b MAGGIORE HOSPITAL   (Italy)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d GILEAD SCIENCES   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Acyclic nucleotides; Carbocyclic nucleotides; G protein coupled receptor; P2Y 1 nucleotide receptor; Platelet aggregation; Purines

Indexed keywords

2 IODO N 6 METHYLMETHANOCARBA 2' DEOXYADENOSINE 3',5' BIPHOSPHONATE; ACYCLIC NUCLEOSIDE; ADENOSINE DIPHOSPHATE; CALCIUM; CARBON; CYCLIC AMP; MRS 2298; MRS 2496; MRS 2500; PHOSPHONIC ACID DERIVATIVE; PHOSPHORUS; PROTEIN INHIBITOR; PURINE P2Y1 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CHEMICAL BOND; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; DRUG HYDROLYSIS; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STABILITY; HUMAN; HUMAN CELL; IC 50; OBSERVATION; PREDICTION; PRIORITY JOURNAL; RECEPTOR BINDING; THROMBOCYTE AGGREGATION INHIBITION;

ADENOSINE DIPHOSPHATE; BLOOD PLATELETS; CYCLIC AMP; DEOXYADENINE NUCLEOTIDES; HUMANS; PHOSPHOLIPASE C; PLATELET AGGREGATION; RECEPTORS, PURINERGIC P2;

EID: 5144234641     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.06.026     Document Type: Article

References (31)

1. B.B. Fredholm, M.P. Abbracchio, G. Burnstock, G.R. Dubyak, T.K. Harden, and K.A. Jacobson Towards a revised nomenclature for PI and P2 receptors Trends Pharmacol. Sci. 18 1997 79 82
2. K.A. Jacobson, S. Costanzi, M. Ohno, B.V. Joshi, P. Besada, and B. Xu Molecular recognition at purine and pyrimidine nucleotide (P2) receptors Curr. Trends Med. Chem. 4 2004 805 819
3. I. von Kügelgen, and A. Wetter Molecular pharmacology of P2Y-receptors Naunyn Schmiedebergs Arch. Pharmacol. 362 2000 310 323
4. 14 receptor) adds diversity to the P2Y receptor family Trends Pharmacol. Sci. 24 2003 52 55
5. 12 receptors in platelet procoagulant activity Arterioscler. Thromb. Vasc. Biol. 23 2003 1941 1947
6. S.P. Kunapuli, Z. Ding, R.T. Dorsam, S. Kim, S. Murugappan, and T.M. Quinton ADP receptors - argets for developing anti thrombotic agents Curr. Pharm. Des. 9 2003 2303 2316
7. C. Leon, M. Alex, A. Klocke, E. Morgenstern, C. Moosbauer, and A. Eckly Platelet ADP receptors contribute to the initiation of intravascular coagulation Blood 103 2004 594 600
8. T.E. Webb, J. Simon, B.J. Krishek, A.N. Bateson, T.G. Smart, and B.F. King Cloning and functional expression of a brain G-protein-coupled ATP receptor FEBS Lett. 324 1993 219 225
9. G. Hollopeter, H.M. Jantzen, D. Vincent, G. Li, L. England, and V. Ramakrishnan Identification of the platelet ADP receptor targeted by antithrombotic drugs Nature 409 2001 202 207
10. C.J. Foster, D.M. Prosser, J.M. Agans, Y. Zhai, M.D. Smith, and J.E. Lachowicz Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs J. Clin. Invest. 107 2001 1591 1598
11. 1-deficient mice Nat. Med. 5 1999 1199 1202
12. 1 receptor-null mice J. Clin. Invest. 104 1999 1731 1737
13. 1 receptor for ATP plays an essential role in platelet aggregation at high shear Haematol. J. 4 Suppl 2 2003 150 (abstract)
14. 1 receptor ligands J. Med. Chem. 43 2000 829 842
15. S.G. Brown, B.F. King, Y-C. Kim, G. Burnstock, and K.A. Jacobson Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors Drug Dev. Res. 49 2000 253 259
16. 1 receptor antagonist Br. J. Pharmacol. 135 2002 2004 2010
17. 1 receptor antagonist Br. J. Pharmacol. 135 2002 2004 2010
18. 1 receptor with a high affinity radiolabeled antagonist Mol. Pharmacol. 62 2002 1249 1257
19. 1 receptor antagonists J. Med. Chem. 46 2003 4974 4987
20. 1 receptor antagonist Eur. J. Pharmacol. 412 2001 213 221
21. 1 receptor antagonist J. Thromb. Haemost. 1 2003 1144 1149
22. 1 receptor: structure activity relationships and receptor docking J. Med. Chem. 44 2001 3092 3108
23. B. Xu, A. Stephens, G. Kirschenheuter, A.F. Greslin, X. Cheng, and J. Sennelo Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: Phosphate substitution leads to multiple pathways of inhibition of platelet aggregation J. Med. Chem. 45 2002 5694 5709
24. Y. Yoshimura, H.R. Moon, Y. Choi, and V.E. Marquez Enantioselective synthesis of bicyclo[3.1.0]hexane carbocyclic nucleosides via a lipase-catalyzed asymmetric acetylation characterization of an unusual acetal byproduct J. Org. Chem. 67 2002 5938 5945
25. J.F. Mustard, D.W. Perry, N.G. Ardlie, and M.A. Packham Preparation of suspensions of washed platelets from humans Br. J. Haematol. 22 1972 193 204
26. CYC receptors Arterioscler. Thromb. Vasc. Biol. 20 2000 101 106
27. M. Cattaneo, A. Lecchi, A.M. Randi, J.L. McGregor, and P.M. Mannucci Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate Blood 80 1992 2787 2796
28. M.W. Gorman, K. Ogimoto, M.V. Savage, K.A. Jacobson, and E. Feigl Nucleotide coronary vasodilation in guinea pig hearts Am. J. Physiol. 285 2003 H1040 H1047
29. 1, in thrombin-induced platelet activation Thromb. Res. 111 2003 65 73
30. K.K. Cheung, M. Ryten, and G. Burnstock Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development Dev. Dyn. 228 2003 254 266
31. 1 cation channel in thrombosis of small arteries in vivo J. Exp. Med. 198 2003 661 667