Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate

British Journal of Pharmacology

Volumn 124, Issue 1, 1998, Pages 1-3

  Boyer, José L ^a   Mohanram, Arvind ^a   Camaioni, Emidio ^b   Jacobson, Kenneth A ^b   Harden, T Kendall ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Inositol lipid signalling; P2Y1 antagonist; P2Y1 receptor; Phospholipase C; Turkey erythrocytes

Indexed keywords

DEOXYADENOSINE DIPHOSPHATE; INOSITOL PHOSPHATE; PHOSPHOLIPASE C; PURINE P2Y RECEPTOR;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; ERYTHROCYTE MEMBRANE; HUMAN; HUMAN CELL; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TURKEY (BIRD);

ADENOSINE DIPHOSPHATE; ANIMALS; ERYTHROCYTE MEMBRANE; HUMANS; RATS; RECEPTORS, PURINERGIC P2; TUMOR CELLS, CULTURED; TURKEYS;

EID: 0031919104     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701837     Document Type: Article

References (11)

1. BOYER, J.L., ROMERO, T., SCHACHTER, J.B. & HARDEN, T.K. (1996a). Identification of competitive antagonists of the P2Y1 receptor. Mol. Pharmacol., 50, 1323-1329.
2. BOYER, J.L., SCHACHTER, J.B., SROMEK, S.M., PALMER, R.K., JACOBSON, K.A., NICHOLAS, R.A. & HARDEN, T.K. (1996b). Avian and human homologues of the P2Y1 receptor: pharmacological, signaling, and molecular properties. Drug Dev. Res., 39, 253-261.
3. BOYER, J.L., WALDO, G.L. & HARDEN, T.K. (1997). Molecular cloning and expression of an avian G protein-coupled P2Y receptor. Mol. Pharmacol., 52, 928-934.
4. BOYER, J.L., ZOHN, I., JACOBSON, K.A. & HARDEN, T.K. (1994). Differential effects of putative P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors. Br. J. Pharmacol., 113, 614-620.
5. 2-purinoceptor antagonists discriminate three contraction-mediating receptors for ATP in rat vas deferens. Naunvn Schmiedebergs Arch. Pharmacol., 349, 74-80.
6. CAMAIONI, E., BOYER, J.L., MOHANRAM, A., HARDEN, T.K. & JACOBSON, K.A. (1998). Deoxyadenosine-bisphosphate derivatives as potent antagonists at P2Y1 receptors. J. Med. Chem., 41, 183-190.
7. CHARLTON, S.J., BROWN, C.A., WEISMAN, G.A., TURNER, J.T. & BOARDER, M.R. (1996). PPADS and Suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br. J. Pharmacol, 118, 704-710.
8. HARDEN, T.K., BOYER, J.L. & NICHOLAS, R.A. (1995). P2-purinergic receptors: subtype-associated signaling responses and structure. Annu. Rev. Pharmacol. Toxicol., 35, 541-579.
9. HUMPHRIES, R.G., TOMLINSON, W., CLEGG, J.A., INGALL, A.H., KINDON, N.D. & LEFF, P. (1995). Pharmacological profile of the novel P2T-purinoceptor antagonist, FLP 67085 in vitro and in the anaesthetized rat in vivo. Br. J. Pharmacol., 115, 1110-1116.
10. LAMBRECHT, G., FRIEBE, T., GRIMM, U., WINDSCHEIF, U., BUNGARDT, E., HILDEBRANDT, C., BAUMERT, H., SPATZKUMBEL, G. & MUTSCHLER, E (1992). PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur. J. Pharmacol., 217, 217-219.
11. 2x-purinoceptor-mediated responses in the rabbit urinary bladder. Br. J. Pharmacol., 110, 1491-1495.