메뉴 건너뛰기




Volumn 30, Issue 1, 2010, Pages 29-38

Phenotypic approaches to gene mapping in platelet function disorders Identification of new variant of P2Y12, TxA2 and GPVI receptors

Author keywords

Platelet dysfunction

Indexed keywords

ADENOSINE DIPHOSPHATE; COLLAGEN; THROMBOXANE A2;

EID: 77949281858     PISSN: 07209355     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1617145     Document Type: Review
Times cited : (38)

References (55)
  • 1
    • 0023185207 scopus 로고
    • A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia
    • Sugiyama T et al. A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. Blood 1987; 69: 1712-1720.
    • (1987) Blood , vol.69 , pp. 1712-1720
    • Sugiyama, T.1
  • 2
    • 0030790042 scopus 로고    scopus 로고
    • Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain
    • Gibbins JM et al. Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain. FEBS Lett 1997; 413: 255-259.
    • (1997) FEBS Lett , vol.413 , pp. 255-259
    • Gibbins, J.M.1
  • 3
    • 0035843178 scopus 로고    scopus 로고
    • Identification of the platelet ADP receptor targeted by antithrombotic drugs
    • Hollopeter G et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 2001; 409: 202-207.
    • (2001) Nature , vol.409 , pp. 202-207
    • Hollopeter, G.1
  • 4
    • 38949130475 scopus 로고    scopus 로고
    • Application of high-throughput screening to identify a novel alpha IIb-specific small-molecule inhibitor of alpha IIb beta 3-mediated platelet interaction with fibrinogen
    • Blue R et al. Application of high-throughput screening to identify a novel alpha IIb-specific small-molecule inhibitor of alpha IIb beta 3-mediated platelet interaction with fibrinogen. Blood 2008; 111: 1248-1256.
    • (2008) Blood , vol.111 , pp. 1248-1256
    • Blue, R.1
  • 5
    • 54049152026 scopus 로고    scopus 로고
    • The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: A technology-driven saga of a receptor with twists, turns, and even a bend
    • Coller BS, Shattil SJ. The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood 2008; 112: 3011-3025.
    • (2008) Blood , vol.112 , pp. 3011-3025
    • Coller, B.S.1    Shattil, S.J.2
  • 6
    • 43549096235 scopus 로고    scopus 로고
    • A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia
    • Ghevaert C et al. A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia. Blood 2008; 111: 3407-3414.
    • (2008) Blood , vol.111 , pp. 3407-3414
    • Ghevaert, C.1
  • 7
    • 33748189345 scopus 로고    scopus 로고
    • Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3
    • Larson MK, Watson SP. Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3. Blood 2006; 108: 1509-1514.
    • (2006) Blood , vol.108 , pp. 1509-1514
    • Larson, M.K.1    Watson, S.P.2
  • 8
    • 66549084876 scopus 로고    scopus 로고
    • A HaemAtlas: Characterizing gene expression in differentiated human blood cells
    • Watkins NA et al. A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood 2009; 113: e1-e9.
    • (2009) Blood , vol.113
    • Watkins, N.A.1
  • 9
    • 67849089161 scopus 로고    scopus 로고
    • A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways
    • Jones CI et al. A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways. Blood 2009; 114: 1405-1416.
    • (2009) Blood , vol.114 , pp. 1405-1416
    • Jones, C.I.1
  • 11
    • 0025962624 scopus 로고
    • The clinical importance of acquired abnormalities of platelet function
    • George JN, Shattil SJ. The clinical importance of acquired abnormalities of platelet function. N Engl J Med 1991; 324: 27-39.
    • (1991) N Engl J Med , vol.324 , pp. 27-39
    • George, J.N.1    Shattil, S.J.2
  • 12
    • 33750546250 scopus 로고    scopus 로고
    • A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO
    • Bolton-Maggs PH et al. A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO. Br J Haematol 2006; 135: 603-633.
    • (2006) Br J Haematol , vol.135 , pp. 603-633
    • Bolton-Maggs, P.H.1
  • 13
    • 33644977050 scopus 로고    scopus 로고
    • A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: Results from a multicenter European study (MCMDM-1 VWD)
    • Tosetto A et al. A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1 VWD). J Thromb Haemost 2006; 4: 766-773.
    • (2006) J Thromb Haemost , vol.4 , pp. 766-773
    • Tosetto, A.1
  • 14
    • 3042705848 scopus 로고    scopus 로고
    • Bleeding risks associated with inheritance of the Quebec platelet disorder
    • McKay H et al. Bleeding risks associated with inheritance of the Quebec platelet disorder. Blood 2004; 104: 159-165.
    • (2004) Blood , vol.104 , pp. 159-165
    • McKay, H.1
  • 15
    • 67949091189 scopus 로고    scopus 로고
    • Evaluation of the diagnostic utility for von Willebrand disease of a pediatric bleeding questionnaire
    • Bowman M et al. Evaluation of the diagnostic utility for von Willebrand disease of a pediatric bleeding questionnaire. J Thromb Haemost 2009; 7: 1418-1421.
    • (2009) J Thromb Haemost , vol.7 , pp. 1418-1421
    • Bowman, M.1
  • 16
    • 34247896877 scopus 로고    scopus 로고
    • Glanzmann thrombasthenia
    • Nurden AT. Glanzmann thrombasthenia. Orphanet J Rare Dis 2006; 1: 10.
    • (2006) Orphanet J Rare Dis , vol.1 , pp. 10
    • Nurden, A.T.1
  • 17
    • 33846606357 scopus 로고    scopus 로고
    • Bernard-Soulier syndrome (hemorrhagiparous thrombocytic dystrophy)
    • Lanza F. Bernard-Soulier syndrome (hemorrhagiparous thrombocytic dystrophy). Orphanet J Rare Dis 2006; 1: 46.
    • (2006) Orphanet J Rare Dis , vol.1 , pp. 46
    • Lanza, F.1
  • 18
    • 52949149668 scopus 로고    scopus 로고
    • Disorders of lysosome-related organelle biogenesis: Clinical and molecular genetics
    • Huizing M et al. Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics. Annu Rev Genomics Hum Genet 2008; 9: 359-386.
    • (2008) Annu Rev Genomics Hum Genet , vol.9 , pp. 359-386
    • Huizing, M.1
  • 19
    • 29244443387 scopus 로고    scopus 로고
    • A germline mutation in BLOC1S3/reduced pigmentation causes a novel variant of Hermansky-Pudlak syndrome (HPS8)
    • Morgan NV et al. A germline mutation in BLOC1S3/reduced pigmentation causes a novel variant of Hermansky-Pudlak syndrome (HPS8). Am J Hum Genet 2006; 78: 160-166.
    • (2006) Am J Hum Genet , vol.78 , pp. 160-166
    • Morgan, N.V.1
  • 20
    • 66549121768 scopus 로고    scopus 로고
    • LAD-1/variant syndrome is caused by mutations in FERMT3
    • Kuijpers TW et al. LAD-1/variant syndrome is caused by mutations in FERMT3. Blood 2009; 113: 4740-4746.
    • (2009) Blood , vol.113 , pp. 4740-4746
    • Kuijpers, T.W.1
  • 21
    • 61949240364 scopus 로고    scopus 로고
    • A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
    • Malinin NL et al. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat Med 2009; 15: 313-318.
    • (2009) Nat Med , vol.15 , pp. 313-318
    • Malinin, N.L.1
  • 22
    • 55249083592 scopus 로고    scopus 로고
    • Kindlin-3: A new gene involved in the pathogenesis of LAD-III
    • Mory A et al. Kindlin-3: a new gene involved in the pathogenesis of LAD-III. Blood 2008; 112: 2591.
    • (2008) Blood , vol.112 , pp. 2591
    • Mory, A.1
  • 23
    • 61949086409 scopus 로고    scopus 로고
    • Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation
    • Svensson L et al. Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nat Med 2009; 15: 306-312.
    • (2009) Nat Med , vol.15 , pp. 306-312
    • Svensson, L.1
  • 24
    • 33646576875 scopus 로고    scopus 로고
    • A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
    • Feske S et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006; 441: 179-185.
    • (2006) Nature , vol.441 , pp. 179-185
    • Feske, S.1
  • 25
    • 61949190323 scopus 로고    scopus 로고
    • Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation
    • Braun A et al. Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation. Blood 2009; 113: 2056-2063.
    • (2009) Blood , vol.113 , pp. 2056-2063
    • Braun, A.1
  • 26
    • 0032497629 scopus 로고    scopus 로고
    • A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen
    • Quek LS, Bolen J, Watson SP. A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen. Curr Biol 1998; 8: 1137-1140.
    • (1998) Curr Biol , vol.8 , pp. 1137-1140
    • Quek, L.S.1    Bolen, J.2    Watson, S.P.3
  • 27
    • 2342656365 scopus 로고    scopus 로고
    • The diagnosis of von Willebrand disease: A guideline from the UK Haemophilia Centre Doctors' Organization
    • Laffan M et al. The diagnosis of von Willebrand disease: a guideline from the UK Haemophilia Centre Doctors' Organization. Haemophilia 2004; 10: 199-217.
    • (2004) Haemophilia , vol.10 , pp. 199-217
    • Laffan, M.1
  • 28
    • 33645557848 scopus 로고    scopus 로고
    • Platelet function analyzer (PFA)-100 closure time in the evaluation of platelet disorders and platelet function
    • Hayward CP et al. Platelet function analyzer (PFA)-100 closure time in the evaluation of platelet disorders and platelet function. J Thromb Haemost 2006; 4: 312-319.
    • (2006) J Thromb Haemost , vol.4 , pp. 312-319
    • Hayward, C.P.1
  • 29
    • 63149094900 scopus 로고    scopus 로고
    • Screening tests of platelet function: Update on their appropriate uses for diagnostic testing
    • Harrison P, Mumford A. Screening tests of platelet function: update on their appropriate uses for diagnostic testing. Semin Thromb Hemost 2009; 35: 150-157.
    • (2009) Semin Thromb Hemost , vol.35 , pp. 150-157
    • Harrison, P.1    Mumford, A.2
  • 30
    • 49149096344 scopus 로고    scopus 로고
    • Platelet function testing: Practice among UK National External Quality Assessment Scheme for Blood Coagulation participants, 2006
    • Jennings I et al. Platelet function testing: practice among UK National External Quality Assessment Scheme for Blood Coagulation participants, 2006. J Clin Pathol 2008; 61: 950-954.
    • (2008) J Clin Pathol , vol.61 , pp. 950-954
    • Jennings, I.1
  • 31
    • 70249101426 scopus 로고    scopus 로고
    • Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: A report from the platelet physiology subcommittee of the SSC of the ISTH
    • Cattaneo M et al. Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTH. J Thromb Haemost 2009; 7: 1029.
    • (2009) J Thromb Haemost , vol.7 , pp. 1029
    • Cattaneo, M.1
  • 32
    • 46749112199 scopus 로고    scopus 로고
    • An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts
    • Hayward CP et al. An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts. Thromb Haemost 2008; 100: 134-145.
    • (2008) Thromb Haemost , vol.100 , pp. 134-145
    • Hayward, C.P.1
  • 33
    • 34547170162 scopus 로고    scopus 로고
    • Reference curves for aggregation and ATP secretion to aid diagnose of platelet-based bleeding disorders: Effect of inhibition of ADP and thromboxane A(2) pathways
    • Dawood BB, Wilde J, Watson, SP. Reference curves for aggregation and ATP secretion to aid diagnose of platelet-based bleeding disorders: effect of inhibition of ADP and thromboxane A(2) pathways. Platelets 2007; 18: 329-345.
    • (2007) Platelets , vol.18 , pp. 329-345
    • Dawood, B.B.1    Wilde, J.2    Watson, S.P.3
  • 34
    • 63049118580 scopus 로고    scopus 로고
    • Diagnostic utility of light transmission platelet aggregometry: Results from a prospective study of individuals referred for bleeding disorder assessments
    • Hayward CP et al. Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessments. J Thromb Haemost 2009; 7: 676-684.
    • (2009) J Thromb Haemost , vol.7 , pp. 676-684
    • Hayward, C.P.1
  • 35
    • 70449334541 scopus 로고    scopus 로고
    • Diagnosis of mild platelet function disorders. Reliability and usefulness of light transmission platelet aggregation and serotonin secretion assays
    • Quiroga T et al. Diagnosis of mild platelet function disorders. Reliability and usefulness of light transmission platelet aggregation and serotonin secretion assays. Br J Haematol 2009; 147: 729-736.
    • (2009) Br J Haematol , vol.147 , pp. 729-736
    • Quiroga, T.1
  • 36
    • 69249215479 scopus 로고    scopus 로고
    • Glycoprotein analysis for the diagnostic evaluation of platelet disorders
    • Miller JL. Glycoprotein analysis for the diagnostic evaluation of platelet disorders. Semin Thromb Hemost 2009; 35: 224-232.
    • (2009) Semin Thromb Hemost , vol.35 , pp. 224-232
    • Miller, J.L.1
  • 37
    • 67349259136 scopus 로고    scopus 로고
    • Whole blood platelet aggregometry and platelet function testing
    • McGlasson DL, Fritsma GA. Whole blood platelet aggregometry and platelet function testing. Semin Thromb Hemost 2009; 35: 168-180.
    • (2009) Semin Thromb Hemost , vol.35 , pp. 168-180
    • McGlasson, D.L.1    Fritsma, G.A.2
  • 38
    • 69249219312 scopus 로고    scopus 로고
    • Role of platelet electron microscopy in the diagnosis of platelet disorders
    • Clauser S, Cramer-Borde E. Role of platelet electron microscopy in the diagnosis of platelet disorders. Semin Thromb Hemost 2009; 35: 213-223.
    • (2009) Semin Thromb Hemost , vol.35 , pp. 213-223
    • Clauser, S.1    Cramer-Borde, E.2
  • 39
    • 2242438075 scopus 로고    scopus 로고
    • Differential effects of reduced glycoprotein VI levels on activation of murine platelets by glycoprotein VI ligands
    • Snell DC et al. Differential effects of reduced glycoprotein VI levels on activation of murine platelets by glycoprotein VI ligands. Biochem J 2002; 368: 293-300.
    • (2002) Biochem J , vol.368 , pp. 293-300
    • Snell, D.C.1
  • 40
    • 77949310443 scopus 로고    scopus 로고
    • Dawood B et al. Identification of a novel homo - zygous P2Y12 mutation in a patient with a mild platelet-based bleeding disorder. J Thromb Haemost 2009; 5 PP-MO-076.
    • Dawood B et al. Identification of a novel homo - zygous P2Y12 mutation in a patient with a mild platelet-based bleeding disorder. J Thromb Haemost 2009; 5 PP-MO-076.
  • 41
    • 77949304427 scopus 로고    scopus 로고
    • Mumford AD et al. A novel thromboxane A2 receptor D304N variant which abrogates ligand binding in a patient with a bleeding diathesis. Blood 2009; (Epub ahead of print).
    • Mumford AD et al. A novel thromboxane A2 receptor D304N variant which abrogates ligand binding in a patient with a bleeding diathesis. Blood 2009; (Epub ahead of print).
  • 42
    • 33845967766 scopus 로고    scopus 로고
    • Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD)
    • Goodeve A et al. Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD). Blood 2007; 109: 112-121.
    • (2007) Blood , vol.109 , pp. 112-121
    • Goodeve, A.1
  • 43
    • 77949278116 scopus 로고    scopus 로고
    • Identification of two novel P2Y12 ADP receptor gene defects in patients with type 1 von Willebrand disease
    • OC-MO-131
    • Daly ME et al. Identification of two novel P2Y12 ADP receptor gene defects in patients with type 1 von Willebrand disease. J Thromb Haemost 2009; 5 OC-MO-131.
    • (2009) J Thromb Haemost , pp. 5
    • Daly, M.E.1
  • 44
    • 65449142910 scopus 로고    scopus 로고
    • Identification and characterization of a novel P2Y 12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study
    • Daly ME et al. Identification and characterization of a novel P2Y 12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study. Blood 2009; 113: 4110-4113
    • (2009) Blood , vol.113 , pp. 4110-4113
    • Daly, M.E.1
  • 45
    • 66349105667 scopus 로고    scopus 로고
    • Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis
    • Fontana G et al. Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis. Haematologica 2009; 94: 581-584.
    • (2009) Haematologica , vol.94 , pp. 581-584
    • Fontana, G.1
  • 46
    • 0034323126 scopus 로고    scopus 로고
    • Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: Further evidence that some cases of platelet 'primary secretion defect' are heterozygous for a defect of P2CYC receptors
    • Cattaneo M et al. Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: further evidence that some cases of platelet 'primary secretion defect' are heterozygous for a defect of P2CYC receptors. Arterioscler Thromb Vasc Biol 2000; 20: E101-E106.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20
    • Cattaneo, M.1
  • 47
    • 0141609789 scopus 로고    scopus 로고
    • Inherited platelet-based bleeding disorders
    • Cattaneo M. Inherited platelet-based bleeding disorders. J Thromb Haemost 2003; 1: 1628-1636.
    • (2003) J Thromb Haemost , vol.1 , pp. 1628-1636
    • Cattaneo, M.1
  • 48
    • 28444439191 scopus 로고    scopus 로고
    • Impaired platelet function in a patient with P2Y12 deficiency caused by a mutation in the translation initiation codon
    • Shiraga M et al. Impaired platelet function in a patient with P2Y12 deficiency caused by a mutation in the translation initiation codon. J Thromb Haemost 2005; 3: 2315-2323.
    • (2005) J Thromb Haemost , vol.3 , pp. 2315-2323
    • Shiraga, M.1
  • 49
    • 0037452681 scopus 로고    scopus 로고
    • Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding
    • Cattaneo M et al. Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding. Proc Natl Acad Sci USA 2003; 100: 1978-1983.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1978-1983
    • Cattaneo, M.1
  • 50
    • 33847124920 scopus 로고    scopus 로고
    • Novel molecular defect in the platelet ADP receptor P2Y12 of a patient with haemorrhagic diathesis
    • Remijn JA et al. Novel molecular defect in the platelet ADP receptor P2Y12 of a patient with haemorrhagic diathesis. Clin Chem Lab Med 2007; 45: 187-189.
    • (2007) Clin Chem Lab Med , vol.45 , pp. 187-189
    • Remijn, J.A.1
  • 51
    • 0028170151 scopus 로고
    • Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder
    • Hirata T et al. Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. J Clin Invest 1994; 94: 1662-1667.
    • (1994) J Clin Invest , vol.94 , pp. 1662-1667
    • Hirata, T.1
  • 52
    • 0030299974 scopus 로고    scopus 로고
    • Pathogenetic analysis of five cases with a platelet disorder characterized by the absence of thromboxane A2 (TXA2)-induced platelet aggregation in spite of normal TXA2 binding activity
    • Fuse I et al. Pathogenetic analysis of five cases with a platelet disorder characterized by the absence of thromboxane A2 (TXA2)-induced platelet aggregation in spite of normal TXA2 binding activity. Thromb Haemost 1996; 76: 1080-1085.
    • (1996) Thromb Haemost , vol.76 , pp. 1080-1085
    • Fuse, I.1
  • 53
    • 0032721596 scopus 로고    scopus 로고
    • Mutations of the platelet thromboxane A2 (TXA2) receptor in patients characterized by the absence of TXA2-induced platelet aggregation despite normal TXA2 binding activity
    • Higuchi W et al. Mutations of the platelet thromboxane A2 (TXA2) receptor in patients characterized by the absence of TXA2-induced platelet aggregation despite normal TXA2 binding activity. Thromb Haemost 1999; 82: 1528-1531.
    • (1999) Thromb Haemost , vol.82 , pp. 1528-1531
    • Higuchi, W.1
  • 54
    • 70349263950 scopus 로고    scopus 로고
    • Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations
    • Dumont B et al. Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations. Blood 2009; 114: 1900-1903.
    • (2009) Blood , vol.114 , pp. 1900-1903
    • Dumont, B.1
  • 55
    • 67949091190 scopus 로고    scopus 로고
    • A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder
    • Hermans C et al. A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder. J Thromb Haemost 2009; 7: 1356-1363.
    • (2009) J Thromb Haemost , vol.7 , pp. 1356-1363
    • Hermans, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.