Structure-activity relationships of uridine 5′-diphosphate analogues at the human P2Y6 receptor

Journal of Medicinal Chemistry

Volumn 49, Issue 18, 2006, Pages 5532-5543

  Besada, Pedro ^a   Shin, Dae Hong ^a   Costanzi, Stefano ^a   Ko, Hyojin ^a   Mathé, Christophe ^b   Gagneron, Julien ^b   Gosselin, Gilles ^b   Maddileti, Savitri ^c   Harden, T Kendall ^c   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITÉ DE MONTPELLIER   (France)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; AMINE; AZIDE; CATION; CYCLOHEXANE DERIVATIVE; HYDROXYL GROUP; PURINE P2Y6 RECEPTOR; RIBOSE; SULFIDE; URACIL; URIDINE DIPHOSPHATE;

ARTICLE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; DRUG BINDING SITE; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR RECOGNITION; RECEPTOR UPREGULATION; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; HUMANS; MODELS, MOLECULAR; RECEPTORS, PURINERGIC P2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; URIDINE DIPHOSPHATE;

EID: 33748572631     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060485n     Document Type: Article

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