Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells

British Journal of Pharmacology

Volumn 132, Issue 1, 2001, Pages 173-182

  Simon, J ^a   Vigne, P ^b   Eklund, K M ^a   Michel, A D ^a   Carruthers, A M ^a   Humphrey, P P A ^a   Frelin, C ^b   Barnard, E A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Adenylyl cyclase inhibition; Capillary endothelial cell; Nucleotides

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ADENYLATE CYCLASE; CYCLIC NUCLEOTIDE; FORSKOLIN; MESSENGER RNA; PERTUSSIS TOXIN; PHOSPHONIC ACID DERIVATIVE; RECEPTOR;

ANIMAL CELL; ARTICLE; BRAIN CAPILLARY; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; ENDOTHELIUM CELL; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0035144596     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703816     Document Type: Article

References (49)

1. Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms
2. The regulation of vascular function by P2 receptors: Multiple sites and multiple receptors
3. Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase
4. 1 receptor
5. 1 receptor activation in HL60 cells
6. αs proteins
7. Cloning of human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase
8. Competitive inhibition by adenosine 5′-triphosphate of the actions on human platelets of 2-chloroadenosine 5′-diphosphate, 2-azidoadenosine 5′-diphosphate and 2′-methylthioadenosine 5′-diphosphate
9. Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets
10. 1-deficient mice
11. ADP-receptors
12. ATP, a partial agonist of atypical P2Y purinoceptors in rat brain microvascular endothelial cells
13. 2+ channel in neurones, with both adenosine triphosphates and diphosphates as potent agonists
14. Ligand specificity and ticlopidine effects distinguish three human platelet ADP receptors
15. Extracellular ATP: Effects, sources and fate
16. T purinoceptors on human blood platelets
17. 1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel
18. 1 receptor is necessary for adenosine 5′-diphosphate-induced platelet aggregation
19. 1 receptor: Similarities to the platelet ADP receptor
20. Receptors for ADP on human blood platelets
21. P2T purinoceptors: ADP receptors on platelets
22. Partial agonists, full agonists, antagonists: Dilemmas of definition
23. 2T-purinoceptors
24. Molecular Basis for ADP-induced Platelet Activation. II. The P2Y1 receptor mediated ADP-induced intracellular calcium mobilization and shape change in platelets
25. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation
26. Differences between natural and recombinant G protein-coupled receptor systems with varying receptor/G protein stochiometry
27. 1 receptor is essential for ADP-induced shape change and aggregation in mouse platelets
28. Multiple P2 receptor subtypes on platelets: A new interpretation of their function
29. Identification of an ecto-nucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists
30. 1 receptor-null mice
31. 1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells
32. Nucleotide receptors
33. i2 proteins
34. 1 receptor
35. Differential effects of adenine nucleotide analogues on shape change and aggregation induced by adenosine 5′diphosphate (ADP) in human platelets
36. Receptors for purines and pyrimidines
37. Role of P2Y1 purinoceptor in ADP-induced platelet activation
38. Evidence for the existence of 2 different ADP-binding sites on rat platelets
39. 3H]-2-methylthioADP to rat platelets - Effect of Clopidogrel and Ticlopidine
40. 1-purinoceptor
41. 1A receptors: Considerations on receptor- effector coupling across systems
42. Characterisation of putative P2T receptor endogenously expressed in rat glioma and brain microvascular endothelial cells
43. Characterization of a recombinant P2Y purinoceptor
44. Pre-steady state study of beta-adrenergic and purinergic receptor interaction in C6 cell membranes: Undelayed balance between positive and negative coupling to adenylyl cyclase
45. NC-IUPHAR Recommendations for Nomenclature of Receptors
46. 1 receptors and of platelet aggregation
47. The P2Y purinoceptors in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase
48. Cloning and functional expression of a rat brain G-protein-coupled ATP receptor