Coupling of the nucleotide P2Y 4 receptor to neuronal ion channels

British Journal of Pharmacology

Volumn 138, Issue 2, 2003, Pages 400-406

  Filippov, Alexander K ^a   Simon, Joseph ^b   Barnard, Eric A ^b   Brown, David A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Calcium channels; Ion channels; M current; Nucleotide receptors; P2Y receptors; P2Y 4 receptor; Potassium channels; UTP

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL N TYPE; COMPLEMENTARY DNA; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; NORADRENALIN; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITIDE; POTASSIUM CHANNEL; PURINE P2Y RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; TRANSDUCIN; URIDINE TRIPHOSPHATE; ION CHANNEL; PURINE P2 RECEPTOR; PURINE P2Y4 RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; MEMBRANE CURRENT; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SUPERIOR CERVICAL GANGLION; SYMPATHETIC NERVE; ANIMAL; CELL MEMBRANE POTENTIAL; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; HUMAN; METABOLISM; NERVE CELL; PHYSIOLOGY;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ION CHANNELS; MEMBRANE POTENTIALS; NEURONS; RATS; RECEPTORS, PURINERGIC P2; URIDINE TRIPHOSPHATE;

EID: 0037275231     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705043     Document Type: Article

References (45)

1. 12, an important drug target in platelets. Trends Pharmacol. Sci., 22, 388-391.
2. BARNARD, E.A., SIMON, J. & WEBB, T.E. (1997). Nucleotide receptors in the nervous system - an abundant component using diverse transduction mechanisms. Mol. Neurobiol., 15, 103-129.
3. 4 nucleotide receptor. Br. J. Pharmacol., 124, 428-430.
4. BOFILL-CARDONA, E., VARTIAN, N., NANOFF, C., FREISSMUTH, M. & BOEHM, S. (2000). Two different signaling mechanisms involved in the excitation of rat sympathetic neurons by uridine nucleotides. Mol. Pharmacol., 57, 1165-1172.
5. BROWN, D.A., FILIPPOV, A.K. & BARNARD, E.A. (2000). Inhibition of potassium and calcium currents in neurones by molecularly-defined P2Y receptors. J. Autonomic Nervous System, 81, 31-36.
6. BROWN, D.A., MARRION, N.V. & SMART, T.G. (1989). On the transduction mechanism for muscarine-induced inhibition of M-current in cultured rat sympathetic neurones. J. Physiol., 413, 469-488.
7. o in rat sympathetic neurones. J. Physiol., 477, 415-422.
8. 2+ potentiates ATP-activated currents in rat sympathetic neurons. Pflug. Arch., 424, 152-158.
9. 4 receptor. Eur. J. Pharmacol., 317, 383-389.
10. COMMUNI, D., PIROTTON, S., PARMENTIER, M. & BOEYNAEMS, J.M. (1995). Cloning and functional expression of a human uridine nucleotide receptor. J. Biol. Chem., 270, 30849-30852.
11. DELMAS, P., ABOGADIE, F.C., DAYRELL, M., HALEY, J.E., MILLIGAN, G., CAULFIELD, M.P., BROWN, D.A & BUCKLEY, N.J. (1998a). G-proteins and G-protein subunits mediating cholinergic inhibition of N-type calcium currents. Eur. J. Neurosci., 10, 1654-1666.
12. 2+ channels in rat sympathetic neurones. J. Physiol., 518, 23-36.
13. 2+ current inhibition by neurotransmitters in rat sympathetic neurones. J. Physiol., 495, 353-366.
14. 2+ channel in neurones, with both adenosine triphosphates and diphosphates as potent agonists. Br. J. Pharmacol., 129, 1063-1066.
15. 2 nucleotide receptors of N-type calcium currents in rat sympathetic neurones. Br. J. Pharmacol., 121, 849-851.
16. + currents. J. Neurosci., 18, 5170-5179.
17. + currents in rat sympathetic neurones. Br. J. Pharmacol., 126, 1009-1017.
18. q contributes to muscarinic inhibition of the M-type potassium current in sympathetic neurons. J. Neurosci., 18, 4521-4531.
19. HALEY, J.E., DELMAS, P., OFFERMANNS, S., ABOGADIE, F.C., SIMON, M.I., BUCKLEY, N.J. & BROWN, D.A. (2000). Muscarinic inhibition of calcium current and M current in Galpha q deficient mice. J. Neurosci., 20, 3973-3979.
20. HEPLER, J.R (1999). Emerging roles for RGS proteins in cell signalling. Trends Pharmacol. Sci., 20, 376-382.
21. 2+ channels by G-protein βγ subunits. Nature. 105, 113-119.
22. HILLE, B. (1994). Modulation of ion-channel function by G-protein-coupled receptors. Trends Neurosci., 17, 531-536.
23. IKEDA, S.R. (1996). Voltage-dependent modulation of N-type calcium channels by G-protein βγ subunits. Nature, 380, 255-258.
24. IKEDA, S.R., LOVINGER, D.M., MCCOOL, B.A. & LEWIS, D.L. (1995). Heterologous expression of metabotropic glutamate receptors in adult rat sympathetic neurons: subtype-specific coupling to ion channels. Neuron, 14, 1029-1038.
25. 2+ channel modulation in sympathetic neurons. Proc. Natl. Acad. Sci. U.S.A., 97, 907-912.
26. q/11. Neuron, 14, 399-405.
27. 2+ channels via heterotrimeric G-proteins in neurons. Jpn. J. Pharmacol., 81, 324-331.
28. 4 receptor. Mol. Pharmacol., 57, 926-931.
29. LAZAROWSKI, E.R., ROCHELLE, L.G., O'NEAL, W.K., RIBEIRO, C.M., GRUBB, B.R., ZHANG, V., HARDEN, T.K. & BOUCHER. R.C. (2001). Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder. J. Pharmacol. Exp. Ther., 297, 43-49.
30. 2Y purinoceptor subtypes recruit different Mek activators in astrocytes. Br. J. Pharmacol., 129, 927-936.
31. 1 purinergic receptor in neurons and glial cells of the central nervous system. Mol. Brain Res., 78, 50-58.
32. 1 purinergic receptor in the human brain: striking neuronal localisation. J. Comp. Neurol., 421, 374-384.
33. i3. J. Biol. Chem., 273, 4695-4704.
34. NGUYEN, T., ERB, L., WEISMAN, G.A., MARCHESE, A., HENG, H.H., GARRAD, R.C., GEORGE, S.R., TURNER, J.T. & O'DOWD, B.F. (1995). Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. J. Biol. Chem., 270, 30845-30848.
35. NORTH, R.A. & BARNARD, E.A. (1997). Nucleotide receptors. Current Opin. Neurobiol., 7, 346-357.
36. RALEVIC, V. & BURNSTOCK, G. (1998). Receptors for purines and pyrimidines. Pharmacol. Rev., 50, 413-492.
37. SAK, K., BARNARD, E.A. & JARV. J. (2000). Dual effect of nucleotides on P2Y receptors. IUBMB Life, 50, 99-103.
38. SCHROEDER, B.C., HECHENBERGER, M., WEINREICH, F., KUBISCH. C. & JENTSCH, T.J. (2000). KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J. Biol. Chem., 275, 24089-24095.
39. +) channel subunit, Ergl and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell. J. Neurosci., 9, 7742-7756.
40. 1 muscarinic acetylcholine receptors. J. Physiol., 522, 349-355.
41. 4 nucleotide receptor. Eur. J. Pharmacol., 416, 197-202.
42. WANG, H.S., PAN, Z., SHI, W., BROWN, B.S., WYMORE, R.S., COHEN, I.S., DIXON, J.E. & MCKINNON, D. (1998). KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science, 282, 1890-1893.
43. WEBB, T.E., BOLUYT, M.O. & BARNARD, E.A. (1996). Molecular biology of P2Y purinoceptors: Expression in rat heart. J. Autonom. Pharmacol., 16, 303-307.
44. 1 mRNA within the chick brain. Neuroscience, 84, 825-837.
45. 4 receptor. J. Neurochem., 71, 1348-1357.