P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries

Journal of Clinical Investigation

Volumn 112, Issue 3, 2003, Pages 398-406

  André, Patrick ^a   Delaney, Suzanne M ^a   LaRocca, Thomas ^a   Vincent, Diana ^a   DeGuzman, Francis ^a   Jurek, Marzena ^a   Koller, Beverley ^b   Phillips, David R ^a   Conley, Pamela B ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; COLLAGEN; FIBRINOGEN; PROTEINASE ACTIVATED RECEPTOR 4; PURINE P2Y12 RECEPTOR; VON WILLEBRAND FACTOR; FIBRINOLYTIC AGENT; MEMBRANE PROTEIN; P2RY12 PROTEIN, HUMAN; P2RY12 PROTEIN, MOUSE; PURINE P2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INJURY; ARTERY THROMBOSIS; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; EMBRYO; ENZYME ACTIVATION; FEMALE; GENE CONTROL; GENE TARGETING; IN VIVO STUDY; MALE; MESENTERIC ARTERY; MOUSE; MOUSE STRAIN; NONHUMAN; NULL ALLELE; POPULATION; PRIORITY JOURNAL; RECEPTOR GENE; REGULATORY MECHANISM; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; TIME; TREATMENT FAILURE; ANIMAL; BIOLOGICAL MODEL; BLOOD; C57BL MOUSE; DRUG EFFECT; GENETICS; HUMAN; INJURY; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; THROMBOCYTE ADHESIVENESS; THROMBOSIS;

ANIMALS; ASPIRIN; FIBRINOLYTIC AGENTS; HUMANS; MEMBRANE PROTEINS; MESENTERIC ARTERIES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, CARDIOVASCULAR; PLATELET ACTIVATION; PLATELET ADHESIVENESS; RECEPTORS, PURINERGIC P2; THROMBOSIS;

EID: 85047694005     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI17864     Document Type: Article

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