Uridine nucleotide selectivity of three phospholipase C-activating P 2 receptors: Identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor

Molecular Pharmacology

Volumn 50, Issue 2, 1996, Pages 224-229

  Nicholas, Robert A ^a,b   Watt, William C ^a   Lazarowski, Eduardo R ^a   Li, Qing ^a   Harden, T Kendall ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b AMERICAN HEART ASSOCIATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; PURINE P2 RECEPTOR; PURINE P2Y RECEPTOR; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

ARTICLE; ASTROCYTOMA CELL; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; GLIOMA CELL; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; HUMANS; PHOSPHOLIPASE C; RATS; RECEPTORS, PURINERGIC P2; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

EID: 0029788548     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Burnstock, G. Purinergic nerves and receptors. Prog. Biochem. Pharmacol. 16:141-154 (1980).
2. 2-purinergic receptors for extracellular ATP and other nucleotides. Am. J. Physiol. 265:C577-C606 (1993).
3. 2-purinergic receptors: subtype-associated signaling responses and structure. Anna. Rev. Pharmacol. Toxicol. 35:541-579 (1995).
4. Goetz, U., M. DaPrada, and A. Pletacher. Adenine-, guanine-, and uridine-5′-phosphonucleotides in blood platelets and storage organelles of various species. J. Pharmacol. Exp. Ther. 178:210-215 (1971).
5. Richards, S. M., K. A. Dora, S. Rattigan, E. Q. Colquhoun, and M. G. Clark. Role of extracellular UTP in the release of uracil from vasoconstricted hindlimb. Am. J. Physiol. 264:H233-H237 (1993).
6. 2+ concentration induced by mechanical stimulation is propagated via release of pyrophosphorylated nucleotides in mammary epithelial cells. Pfluegers Arch. 427:533-542 (1994).
7. Seifert, R., and G. Schultz. Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides. Trends Pharmacol. Sci. 10:365-369 (1989).
8. Urquilla, P. R. Prolonged contraction of isolated human canine cerebral arteries induced by uridine 5′-triphosphate. Stroke 9:133-136 (1978).
9. Lustig, K. D., A. K. Shiau, A. J. Brake, and D. Julius. Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc. Natl. Acad. Sci. USA 90:5113-5117 (1993).
10. 2U nucleotide receptor, a target for cystic fibrosis pharmacology. Proc. Natl. Acad. Sci. USA 91:3275-3279 (1994).
11. 2U-purinergic receptor: potent activation by diadenosine tetraphosphate. Br. J. Pharmacol. 116:1619-1627 (1995).
12. Lazarowski, E. R., and T. K. Harden. Identification of a uridine nucleotide-selective G-protein-linked receptor that activates phospholipase C. J. Biol. Chem. 269:11830-11836 (1994).
13. 2 nucleotide receptor. J. Biol. Chem. 270:26152-26158 (1995).
14. Communi, D., S. Pirotton, M. Parmentier, and J. M. Boeynaems. Cloning and functional expression of a human uridine nucleotide receptor. J. Biol. Chem. 270:30849-30852 (1995).
15. Nguyen, T., L. Erb, G. A. Weisman, A. Marchese, H. H. Q. Heng, R. C. Garrad, S. R. George, J. T. Turner, and B. F. O'Dowd. Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. J. Biol. Chem. 270:30845-30848 (1995).
16. Olsen, J. C., L. G. Johnson, M. L. Wong-Sun, K. L. Moore, R. Swanstrom, and R. C. Boucher. Efficient retrovirus-mediating gene transfer with long term expression in cystic fibrosis airway epithelial cells. Nucleic Acids Res. 21:663-669 (1993).
17. 2Y-purinergic receptor that couples to phospholipase C. Mol. Pharmacol. 46:8-14 (1994).
18. 2U-purinoceptors. Br. J. Pharmacol. 117:209-216 (1996).
19. 2 purinoceptor, in rabbit ear artery. Naunyn-Schmiedeberg's Arch. Pharmacol, 336:556-560 (1987).
20. 2-purinergic receptors for extracellular ATP. Am. J. Respir. Cell Mol. Biol. 4:295-300 (1991).
21. 2Y-purinergic receptors. Br. J. Pharmacol. 116:2611-2616 (1995).
22. 2Y1 receptor. Br. J. Pharmacol. 118:167-173 (1996).
23. Chen, C.-C., A. N. Akoplan, L. Sivilotti, D. Colquhoun, G. Burnstock, and J. N. Wood. A P2X purinoceptor expressed by a subset of sensory neurons. Nature (Lond.) 377:428-431 (1995).
24. 2x receptor for extracellular ATP. Nature (Lond.) 371:516-519 (1994).
25. Brake, A. J., M. J. Wagenbach, and D. Julius. A new structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature (Lond.) 371:519-523 (1994).
26. Bo, X., Y. Zhang, M. Nassar, G. Burnstock, and R. Schoepfer. A P2X purinoceptor cDNA conferring a novel pharmacological profile. FEBS Lett. 375:129-133 (1995).
27. 2x ATP receptor ion channel with widespread distribution in the brain. J. Neurosci. 16:448-455 (1996).
28. Fredholm, B. B., M. P. Abbracchio, G. Burnstock, J. W. Daly, T. K. Harden, K. A. Jacobson, P. Leff, and M. Williams. Nomenclature and classification of purinoceptors. Pharmacol. Rev. 46:143-156 (1994).