The P2Y13 Met-158-Thr polymorphism, which is in linkage disequilibrium with the P2Y12 locus, is not associated with acute myocardial infarction

PLoS ONE

Volumn 3, Issue 1, 2008, Pages

  Amisten, Stefan ^a   Braun, Oscar Ö ^a   Johansson, Lovisa ^b   Ridderstråle, Martin ^b   Melander, Olle ^b   Erlinge, David ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; METHIONINE; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y13 RECEPTOR; THREONINE; PURINERGIC P2 RECEPTOR;

ACUTE HEART INFARCTION; ADULT; AGED; ARTERY DISEASE; ARTICLE; CARDIOVASCULAR RISK; CASE CONTROL STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE ASSOCIATION; FAMILY HISTORY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; POPULATION RESEARCH; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE ACTIVATION; GENETICS; HEART INFARCTION;

CASE-CONTROL STUDIES; HUMANS; LINKAGE DISEQUILIBRIUM; MYOCARDIAL INFARCTION; POLYMORPHISM, GENETIC; RECEPTORS, PURINERGIC P2;

EID: 44849107924     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001462     Document Type: Article

References (31)

1. Hollopeter G, Jantzen HM, Vincent D, Li G, England I, et al. (2001) Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409: 202-207.
2. Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, et al. (1996) Cloning and chromosomal localization of the human P2Y1 purinoceptor. Biochem Biophys Res Commun 218: 783-788.
3. Zhang FL, Luo L, Gustafson E, Lachowicz J, Smith M, et al. (2001) ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. J Biol Chem 276: 8608-8615.
4. Communi D, Gonzalez NS, Detheux M, Brezillon S, Lannoy V, et al. (2001) Identification ofa novel human ADP receptor coupled to G(i). J Biol Chem 276: 41479-41485.
5. Murugappa S, Kunapuli SP (2006) The role of ADP receptors in platelet function. Front Biosci 11: 1977-1986.
6. Wang L, Olivecrona G, Gotberg M, Olsson ML, Whizell MS, et al. (2005) ADP acting on P2Y13 receptors is a negative feedback pathway for ATP release from human red blood cells. Circ Res 96: 189-196.
7. Cattaneo M, Zighetti ML, Lombardi R, Martinez C, Lecchi A, et al. (2003) Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding. Proc Natl Acad Sci U S A 100: 1978-1983.
8. Remijn JA, MJ IJ, Strunk AL, Abbes AP, Engel H, et al. (2007) Novel molecular defect in the platelet ADP receptor P2Y12 of a patient with haemorrhagic diathesis. Clin Chem Lab Med 45: 187-189.
9. Bertrand ME, Simoons ML, Fox KA, Wallentin LC, Hamm CW, et al. (2002) Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J 23: 1809-1840.
10. Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, et al. (2007) Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes. N Engl J Med.
11. Fontana P, Dupont A, Gandrille S, Bachelot-Loza C, Reny JL, et al. (2003) Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects. Circulation 108: 989-995.
12. Fontana P, Gaussem P, Aiach M, Fiessinger JN, Emmerich J, et al. (2003) P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study. Circulation 108: 2971-2973.
13. Ziegler S, Schillinger M, Funk M, Felber K, Exner M, et al. (2005) Association of a functional polymorphism in the clopidogrel target receptor gene, P2Y12, and the risk for ischemic cerebrovascular events in patients with peripheral artery disease. Stroke 36: 1394-1399.
14. Cavallari U, Trabetti E, Malerba G, Biscuola M, Girelli D, et al. (2007) Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease. BMC Med Genet 8: 59.
15. Cuisset T, Frere C, Quilici J, Morange PE, Saut N, et al. (2007) Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome. Thromb Res.
16. Schettert IT, Pereira AC, Lopes NH, Hueb WA, Krieger JE (2006) Association between platelet P2Y12 haplotype and risk of cardiovascular events in chronic coronary disease. Thromb Res 118: 679-683.
17. von Beckerath N, von Beckerath O, Koch W, Eichinger M, Schomig A, et al. (2005) P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose. Blood Coagul Fibrinolysis 16: 199-204.
18. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, et al. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene 275: 83-91.
19. Criqui MH, Langer RD, Fronek A, Feigelson HS, Klauber MR, et al. (1992) Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med 326: 381-386.
20. McCullough PA (2007) Coronary artery disease. Clin J Am Soc Nephrol 2: 611-616.
21. Amisten S, Melander O, Wihlborg AK, Berglund G, Erlinge D (2006) Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriersof the Thr-87 variant of the ATP receptor P2Y11. Eur Heart J.
22. Manjer J, Carlsson S, Elmstahl S, Gullberg B, Janzon L, et al. (2001) The Malmo Diet and Cancer Study: representativity, cancer incidence and mortality in participants and non-participants. Eur J Cancer Prev 10: 489-499.
23. Orho-Melander M, Klannemark M, Svensson MK, Ridderstrale M, Lindgren CM, et al. (2002) Variants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels. Diabetes 51: 2658-2664.
24. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
25. Skol AD, Scott LJ, Abecasis GR, Boehnke M (2006) Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet 38: 209-213.
26. Coade SB, Pearson JD (1989) Metabolism of adenine nucleotides in human blood. Circ Res 65: 531-537.
27. Bergfeld GR, Forrester T (1992) Release of ATP from human erythrocytes in response to a brief period of hypoxia anq hypercapnia. Cardiovasc Res 26: 40-47.
28. Ramensky V, Bork P, Sunyaev S (2002) Human non-synonymous SNPs: server and survey. Nucleic Acids Res 30: 3894-3900.
29. Leng GC, Lee AJ, Fowkes FG, Whiteman M, Dunbar J, et al. (1996) Incidence, natural history and cardiovascular events, in symptomatic and asymptomatic peripheral arterial disease in the general population. Int J Epidemiol 25: 1172-1181.
30. Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramirez C, Cavallari U, et al. (2005) Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients wiih coronary artery disease. Thromb Res 116: 491-497.
31. Hetherington SL, Singh RK, Lodwick D, Thompson JR, Goodall AH, et al. (2005) Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP. Arterioscler Thromb Vase Biol 25: 252-257.