-
1
-
-
77951891892
-
Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally
-
Sutherland CJ, Tanomsing N, Nolder D et al.: Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally. J. Inf. Dis. 201(10), 1544-1550 (2010).
-
(2010)
J. Inf. Dis.
, vol.201
, Issue.10
, pp. 1544-1550
-
-
Sutherland, C.J.1
Tanomsing, N.2
Nolder, D.3
-
2
-
-
39449099400
-
Plasmodium knowlesi: The fifth human malaria parasite
-
White NJ: Plasmodium knowlesi: the fifth human malaria parasite. Clin. Infect. Dis. 46(2), 172-173 (2008).
-
(2008)
Clin. Infect. Dis.
, vol.46
, Issue.2
, pp. 172-173
-
-
White, N.J.1
-
3
-
-
77955969223
-
Malaria: What can apes teach humans?
-
Cox-Singh J: Malaria: what can apes teach humans? Future Microbiol. 5(8), 1157-1160 (2010).
-
(2010)
Future Microbiol.
, vol.5
, Issue.8
, pp. 1157-1160
-
-
Cox-Singh, J.1
-
4
-
-
41849125318
-
Malaria: Progress, perils, and prospects for eradication
-
Greenwood BM, Fidock DA, Kyle DE et al.: Malaria: progress, perils, and prospects for eradication. J. Clin. Inv. 118(4), 1266-1276 (2008).
-
(2008)
J. Clin. Inv.
, vol.118
, Issue.4
, pp. 1266-1276
-
-
Greenwood, B.M.1
Fidock, D.A.2
Kyle, D.E.3
-
5
-
-
2542451884
-
The global distribution and population at risk of malaria: Past, present, and future
-
Hay SI, Guerra CA, Tatem AJ, Noor AM, Snow RW: The global distribution and population at risk of malaria: past, present, and future. Lancet Infect. Dis. 4(6), 327-336 (2004).
-
(2004)
Lancet Infect. Dis.
, vol.4
, Issue.6
, pp. 327-336
-
-
Hay, S.I.1
Guerra, C.A.2
Tatem, A.J.3
Noor, A.M.4
Snow, R.W.5
-
6
-
-
68949088019
-
The development of the RTS,S malaria vaccine candidate: Challenges and lessons
-
Ballou RW: The development of the RTS,S malaria vaccine candidate: challenges and lessons. Parasite Immunol. 31(9), 492-500 (2009).
-
(2009)
Parasite Immunol.
, vol.31
, Issue.9
, pp. 492-500
-
-
Ballou, R.W.1
-
7
-
-
77954762106
-
The RTS,S malaria vaccine
-
Casares S, Brumeanu TD, Richie TL: The RTS,S malaria vaccine. Vaccine 28(31), 4880-4894 (2010).
-
(2010)
Vaccine
, vol.28
, Issue.31
, pp. 4880-4894
-
-
Casares, S.1
Brumeanu, T.D.2
Richie, T.L.3
-
8
-
-
67649675076
-
Existing antimalarial agents and malaria-treatment strategies
-
DAlessandro U: Existing antimalarial agents and malaria-treatment strategies. Expert Opinion Pharmacother. 10(8), 1291-1306 (2009).
-
(2009)
Expert Opinion Pharmacother.
, vol.10
, Issue.8
, pp. 1291-1306
-
-
Dalessandro, U.1
-
9
-
-
67349124872
-
Wells TNC: The global portfolio of new antimalarial medicines under development
-
Olliaro P, Wells TNC: The global portfolio of new antimalarial medicines under development. Clin. Pharmacol. Therap. 85(6), 584-595 (2009).
-
(2009)
Clin. Pharmacol. Therap.
, vol.85
, Issue.6
, pp. 584-595
-
-
Olliaro, P.1
-
10
-
-
34548635564
-
Advances in understanding the genetic basis of antimalarial drug resistance
-
Ekland EH, Fidock DA: Advances in understanding the genetic basis of antimalarial drug resistance. Curr. Opin. Microbiol. 10(4), 363-370 (2007).
-
(2007)
Curr. Opin. Microbiol.
, vol.10
, Issue.4
, pp. 363-370
-
-
Ekland, E.H.1
Fidock, D.A.2
-
11
-
-
55349093261
-
Drug resistance and genetic mapping in Plasmodium falciparum
-
Hayton K, Su XZ: Drug resistance and genetic mapping in Plasmodium falciparum. Curr. Genet. 54(5), 223-239 (2008).
-
(2008)
Curr. Genet.
, vol.54
, Issue.5
, pp. 223-239
-
-
Hayton, K.1
Su, X.Z.2
-
12
-
-
62549103382
-
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in
-
Dharia NV, Sidhu ABS, Cassera MB et al.: Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol. 10(2), R21 (2009).
-
(2009)
Plasmodium Falciparum. Genome Biol.
, vol.10
, Issue.2
-
-
Dharia, N.V.1
Sidhu, A.B.S.2
Cassera, M.B.3
-
13
-
-
77649188974
-
Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs
-
Mu JB, Myers RA, Jiang HY et al.: Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs. Nature Genet. 42(3), 268-271 (2010).
-
(2010)
Nature Genet.
, vol.42
, Issue.3
, pp. 268-271
-
-
Mu, J.B.1
Myers, R.A.2
Jiang, H.Y.3
-
14
-
-
1142297431
-
Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs
-
Fitch CD: Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs. Life Sci. 74(16), 1957-1972 (2004).
-
(2004)
Life Sci.
, vol.74
, Issue.16
, pp. 1957-1972
-
-
Fitch, C.D.1
-
15
-
-
0023630539
-
Spread of chloroquine resistance in Plasmodium falciparum
-
Payne D: Spread of chloroquine resistance in Plasmodium falciparum. Parasitol. Today 3(8), 241-246 (1987).
-
(1987)
Parasitol. Today
, vol.3
, Issue.8
, pp. 241-246
-
-
Payne, D.1
-
16
-
-
0035884456
-
Chloroquine-resistant malaria
-
Wellems TE, Plowe CV: Chloroquine-resistant malaria. J. Inf. Dis. 184(6), 770-776 (2001).
-
(2001)
J. Inf. Dis.
, vol.184
, Issue.6
, pp. 770-776
-
-
Wellems, T.E.1
Plowe, C.V.2
-
17
-
-
33947125517
-
Quantitative pH measurements in Plasmodium falciparum-infected erythrocytes using pHluorin
-
Kuhn Y, Rohrbach P, Lanzer M: Quantitative pH measurements in Plasmodium falciparum-infected erythrocytes using pHluorin. Cell. Microbiol. 9(4), 1004-1013 (2007).
-
(2007)
Cell. Microbiol.
, vol.9
, Issue.4
, pp. 1004-1013
-
-
Kuhn, Y.1
Rohrbach, P.2
Lanzer, M.3
-
18
-
-
77955253954
-
Hematin-hematin self-association states involved in the formation and reactivity of the malaria parasite pigment, hemozoin
-
Klonis N, Dilanian R, Hanssen E et al.: Hematin-hematin self-association states involved in the formation and reactivity of the malaria parasite pigment, hemozoin. Biochemistry 49(31), 6804-6811 (2010).
-
(2010)
Biochemistry
, vol.49
, Issue.31
, pp. 6804-6811
-
-
Klonis, N.1
Dilanian, R.2
Hanssen, E.3
-
19
-
-
34347221494
-
Understanding resistance to antimalarial 4-aminoquinolines, cinchona alkaloids and the highly hydrophobic arylaminoalcohols
-
Warhurst DC: Understanding resistance to antimalarial 4-aminoquinolines, cinchona alkaloids and the highly hydrophobic arylaminoalcohols. Curr. Science 92(11), 1556-1560 (2007).
-
(2007)
Curr. Science
, vol.92
, Issue.11
, pp. 1556-1560
-
-
Warhurst, D.C.1
-
20
-
-
66949146530
-
Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria
-
Roepe PD: Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria. Future Microbiol. 4(4), 441-455 (2009).
-
(2009)
Future Microbiol.
, vol.4
, Issue.4
, pp. 441-455
-
-
Roepe, P.D.1
-
21
-
-
70349524663
-
Chloroquine transport via the malaria parasites chloroquine resistance transporter
-
Martin RE, Marchetti RV, Cowan AI, Howitt SM, Broer S, Kirk K: Chloroquine transport via the malaria parasites chloroquine resistance transporter. Science 325(5948), 1680-1682 (2009).
-
(2009)
Science
, vol.325
, Issue.5948
, pp. 1680-1682
-
-
Martin, R.E.1
Marchetti, R.V.2
Cowan, A.I.3
Howitt, S.M.4
Broer, S.5
Kirk, K.6
-
22
-
-
72749090340
-
Reduced digestive vacuolar accumulation of chloroquine is not linked to resistance to chloroquine toxicity
-
Cabrera M, Paguio MF, Xie CA, Roepe PD: Reduced digestive vacuolar accumulation of chloroquine is not linked to resistance to chloroquine toxicity. Biochemistry 48(47), 11152-11154 (2009).
-
(2009)
Biochemistry
, vol.48
, Issue.47
, pp. 11152-11154
-
-
Cabrera, M.1
Paguio, M.F.2
Xie, C.A.3
Roepe, P.D.4
-
23
-
-
0033636607
-
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
-
Fidock DA, Nomura T, Talley AK et al.: Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol. Cell 6, 861-871 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 861-871
-
-
Fidock, D.A.1
Nomura, T.2
Talley, A.K.3
-
24
-
-
0026328231
-
Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7
-
Wellems TE, Walker-Jonah A, Panton LJ: Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7. Proc. Natl Acad. Sci. USA 88(8), 3382-3386 (1991).
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, Issue.8
, pp. 3382-3386
-
-
Wellems, T.E.1
Walker-Jonah, A.2
Panton, L.J.3
-
25
-
-
19344366882
-
Pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: A functional and evolutionary perspective
-
Cooper RA, Hartwig CL, Ferdig MT: pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective. Acta Trop. 94(3), 170-180 (2005).
-
(2005)
Acta Trop.
, vol.94
, Issue.3
, pp. 170-180
-
-
Cooper, R.A.1
Hartwig, C.L.2
Ferdig, M.T.3
-
26
-
-
0037020024
-
Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
-
Sidhu ABS, Verdier-Pinard D, Fidock DA: Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science 298(5591), 210-213 (2002).
-
(2002)
Science
, vol.298
, Issue.5591
, pp. 210-213
-
-
Sidhu, A.B.S.1
Verdier-Pinard, D.2
Fidock, D.A.3
-
27
-
-
17144422120
-
Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance
-
Bray PG, Martin RE, Tilley L, Ward SA, Kirk K, Fidock DA: Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance. Mol. Microbiol. 56(2), 323-333 (2005).
-
(2005)
Mol. Microbiol.
, vol.56
, Issue.2
, pp. 323-333
-
-
Bray, P.G.1
Martin, R.E.2
Tilley, L.3
Ward, S.A.4
Kirk, K.5
Fidock, D.A.6
-
28
-
-
4944253804
-
The malaria parasites chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily
-
Martin RE, Kirk K: The malaria parasites chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily. Mol. Biol. Evol. 21(10), 1938-1949 (2004).
-
(2004)
Mol. Biol. Evol.
, vol.21
, Issue.10
, pp. 1938-1949
-
-
Martin, R.E.1
Kirk, K.2
-
29
-
-
1642473952
-
The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamily
-
Tran CV, Saier MH: The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamily. Microbiology 150(1), 1-3 (2004).
-
(2004)
Microbiology
, vol.150
, Issue.1
, pp. 1-3
-
-
Tran, C.V.1
Saier, M.H.2
-
30
-
-
0035371224
-
Evidence for different mechanisms of chloroquine resistance in 2 plasmodium species that cause human malaria
-
Nomura T, Carlton JMR, Baird JK et al.: Evidence for different mechanisms of chloroquine resistance in 2 plasmodium species that cause human malaria. J. Inf. Dis. 183(11), 1653-1661 (2001).
-
(2001)
J. Inf. Dis.
, vol.183
, Issue.11
, pp. 1653-1661
-
-
Nomura, T.1
Carlton, J.M.R.2
Baird, J.K.3
-
31
-
-
0345096564
-
Chloroquine resistance in Plasmodium chabaudi: Are chloroquine-resistance transporter (crt) and multi-drug resistance (mdr1) orthologues involved?
-
Hunt P, Cravo PVL, Donleavy P, Carlton JMR, Walliker D: Chloroquine resistance in Plasmodium chabaudi: are chloroquine-resistance transporter (crt) and multi-drug resistance (mdr1) orthologues involved? Mol. Biochem. Parasitol. 133(1), 27-35 (2004).
-
(2004)
Mol. Biochem. Parasitol.
, vol.133
, Issue.1
, pp. 27-35
-
-
Hunt, P.1
Cravo, P.V.L.2
Donleavy, P.3
Carlton, J.M.R.4
Walliker, D.5
-
32
-
-
63149132005
-
Resistance to antimalarial compounds: Methods and applications
-
Witkowski B, Berry A, Benoit-Vical F: Resistance to antimalarial compounds: methods and applications. Drug Resist. Updates 12(1-2), 42-50 (2009).
-
(2009)
Drug Resist. Updates
, vol.12
, Issue.1-2
, pp. 42-50
-
-
Witkowski, B.1
Berry, A.2
Benoit-Vical, F.3
-
33
-
-
0035945682
-
A molecular marker for chloroquine-resistant falciparum malaria
-
Djimde A, Doumbo OK, Cortese JF et al.: A molecular marker for chloroquine-resistant falciparum malaria. N. Engl. J. Med. 344(4), 257-263 (2001).
-
(2001)
N. Engl. J. Med.
, vol.344
, Issue.4
, pp. 257-263
-
-
Djimde, A.1
Doumbo, O.K.2
Cortese, J.F.3
-
34
-
-
0036806981
-
Genetics of drug-resistant Plasmodium falciparum malaria in the Venezuelan state of Bolivar
-
Contreras CE, Cortese JF, Caraballo A, Plowe CV: Genetics of drug-resistant Plasmodium falciparum malaria in the Venezuelan state of Bolivar. Am. J. Trop. Med. Hyg. 67(4), 400-405 (2002).
-
(2002)
Am. J. Trop. Med. Hyg.
, vol.67
, Issue.4
, pp. 400-405
-
-
Contreras, C.E.1
Cortese, J.F.2
Caraballo, A.3
Plowe, C.V.4
-
35
-
-
2942622405
-
Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro
-
Durrand V, Berry A, Sem R, Glaziou P, Beaudou J, Fandeur T: Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro. Mol. Biochem. Parasitol. 136(2), 273-285 (2004).
-
(2004)
Mol. Biochem. Parasitol.
, vol.136
, Issue.2
, pp. 273-285
-
-
Durrand, V.1
Berry, A.2
Sem, R.3
Glaziou, P.4
Beaudou, J.5
Fandeur, T.6
-
36
-
-
56949096093
-
Association between chloroquine resistance phenotypes and point mutations in pfcrt and pfmdr1 in Plasmodium falciparum isolates from Thailand
-
Rungsihirunrat K, Chaijareonkul W, Seugorn A, Na-Bangchang K, Thaithong S: Association between chloroquine resistance phenotypes and point mutations in pfcrt and pfmdr1 in Plasmodium falciparum isolates from Thailand. Acta Trop. 109(1), 37-40 (2009).
-
(2009)
Acta Trop.
, vol.109
, Issue.1
, pp. 37-40
-
-
Rungsihirunrat, K.1
Chaijareonkul, W.2
Seugorn, A.3
Na-Bangchang, K.4
Thaithong, S.5
-
37
-
-
22744447610
-
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance
-
Lakshmanan V, Bray PG, Verdier-Pinard D et al.: A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance. EMBO J. 24(13), 2294-2305 (2005).
-
(2005)
EMBO J.
, vol.24
, Issue.13
, pp. 2294-2305
-
-
Lakshmanan, V.1
Bray, P.G.2
Verdier-Pinard, D.3
-
39
-
-
33749989605
-
Transporters involved in resistance to antimalarial drugs
-
Valderramos SG, Fidock DA: Transporters involved in resistance to antimalarial drugs. Trends Pharmacol. Sci. 27(11), 594-601 (2006).
-
(2006)
Trends Pharmacol. Sci.
, vol.27
, Issue.11
, pp. 594-601
-
-
Valderramos, S.G.1
Fidock, D.A.2
-
40
-
-
4644251136
-
Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents
-
Johnson DJ, Fidock DA, Mungthin M et al.: Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents. Mol. Cell 15(6), 867-877 (2004).
-
(2004)
Mol. Cell
, vol.15
, Issue.6
, pp. 867-877
-
-
Johnson, D.J.1
Fidock, D.A.2
Mungthin, M.3
-
41
-
-
33748645940
-
PfCRT and the trans-vacuolar proton electrochemical gradient: Regulating the access of chloroquine to ferriprotoporphyrin IX
-
Bray PG, Mungthin M, Hastings IM et al.: PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX. Mol. Microbiol. 62(1), 238-251 (2006).
-
(2006)
Mol. Microbiol.
, vol.62
, Issue.1
, pp. 238-251
-
-
Bray, P.G.1
Mungthin, M.2
Hastings, I.M.3
-
43
-
-
44949197772
-
Inhibition of efflux of quinolines as new therapeutic strategy in malaria
-
Henry M, Alibert S, Rogier C, Barbe J, Pradines B: Inhibition of efflux of quinolines as new therapeutic strategy in malaria. Curr. Top. Med. Chem. 8(7), 563-578 (2008).
-
(2008)
Curr. Top. Med. Chem.
, vol.8
, Issue.7
, pp. 563-578
-
-
Henry, M.1
Alibert, S.2
Rogier, C.3
Barbe, J.4
Pradines, B.5
-
44
-
-
70350067815
-
Chloroquine transport in Plasmodium falciparum. 2. Analysis of pfcrt-mediated drug transport using proteoliposomes and a fluorescent chloroquine probe
-
Paguio MF, Cabrera M, Roepe PD: Chloroquine transport in Plasmodium falciparum. 2. Analysis of pfcrt-mediated drug transport using proteoliposomes and a fluorescent chloroquine probe. Biochemistry 48(40), 9482-9491 (2009).
-
(2009)
Biochemistry
, vol.48
, Issue.40
, pp. 9482-9491
-
-
Paguio, M.F.1
Cabrera, M.2
Roepe, P.D.3
-
45
-
-
70350050569
-
Chloroquine transport in Plasmodium falciparum. 1. Influx and efflux kinetics for live trophozoite parasites using a novel fluorescent chloroquine probe
-
Cabrera M, Natarajan J, Paguio MF, Wolf C, Urbach JS, Roepe PD: Chloroquine transport in Plasmodium falciparum. 1. Influx and efflux kinetics for live trophozoite parasites using a novel fluorescent chloroquine probe. Biochemistry 48(40), 9471-9481 (2009).
-
(2009)
Biochemistry
, vol.48
, Issue.40
, pp. 9471-9481
-
-
Cabrera, M.1
Natarajan, J.2
Paguio, M.F.3
Wolf, C.4
Urbach, J.S.5
Roepe, P.D.6
-
46
-
-
33645751112
-
The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance
-
Hayward R, Saliba KJ, Kirk K: The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance. J. Cell Sci. 119(6), 1016-1025 (2006).
-
(2006)
J. Cell Sci.
, vol.119
, Issue.6
, pp. 1016-1025
-
-
Hayward, R.1
Saliba, K.J.2
Kirk, K.3
-
47
-
-
33750090345
-
Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria
-
DOI 10.1021/bi0610348
-
Gligorijevic B, Bennett T, McAllister R, Urbach JS, Roepe PD: Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria. Biochemistry 45(41), 12411-12423 (2006). (Pubitemid 44583684)
-
(2006)
Biochemistry
, vol.45
, Issue.41
, pp. 12411-12423
-
-
Gligorijevic, B.1
Bennett, T.2
McAllister, R.3
Urbach, J.S.4
Roepe, P.D.5
-
48
-
-
57049091831
-
Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasites digestive vacuole
-
Lehane AM, Kirk K: Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasites digestive vacuole. Antimicrob. Agents Chemoth. 52(12), 4374-4380 (2008).
-
(2008)
Antimicrob. Agents Chemoth.
, vol.52
, Issue.12
, pp. 4374-4380
-
-
Lehane, A.M.1
Kirk, K.2
-
49
-
-
3142618432
-
The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine
-
Zhang HB, Paguio M, Roepe PD: The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine. Biochemistry 43(26), 8290-8296 (2004).
-
(2004)
Biochemistry
, vol.43
, Issue.26
, pp. 8290-8296
-
-
Zhang, H.B.1
Paguio, M.2
Roepe, P.D.3
-
50
-
-
33845711820
-
Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine
-
Cooper RA, Lane KD, Deng BB et al.: Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine. Mol. Microbiol. 63(1), 270-282 (2007).
-
(2007)
Mol. Microbiol.
, vol.63
, Issue.1
, pp. 270-282
-
-
Cooper, R.A.1
Lane, K.D.2
Deng, B.B.3
-
51
-
-
19344377032
-
Contribution of the pfmdr1 gene to antimalarial drug resistance
-
Duraisingh MT, Cowman AF: Contribution of the pfmdr1 gene to antimalarial drug resistance. Acta Trop. 94(3), 181-190 (2005).
-
(2005)
Acta Trop.
, vol.94
, Issue.3
, pp. 181-190
-
-
Duraisingh, M.T.1
Cowman, A.F.2
-
52
-
-
3142772962
-
Dissecting the loci of low-level quinine resistance in malaria parasites
-
Ferdig MT, Cooper RA, Mu JB et al.: Dissecting the loci of low-level quinine resistance in malaria parasites. Mol. Microbiol. 52(4), 985-997 (2004).
-
(2004)
Mol. Microbiol.
, vol.52
, Issue.4
, pp. 985-997
-
-
Ferdig, M.T.1
Cooper, R.A.2
Mu, J.B.3
-
53
-
-
66149137552
-
Plasmodium falciparum Na+/H+ exchanger 1 transporter is involved in reduced susceptibility to quinine
-
Henry M, Briolant S, Zettor A et al.: Plasmodium falciparum Na+/H+ exchanger 1 transporter is involved in reduced susceptibility to quinine. Antimicrob. Agents Chemoth. 53(5), 1926-1930 (2009).
-
(2009)
Antimicrob. Agents Chemoth.
, vol.53
, Issue.5
, pp. 1926-1930
-
-
Henry, M.1
Briolant, S.2
Zettor, A.3
-
54
-
-
62249160684
-
Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE
-
Nkrumah LJ, Riegelhaupt PM, Moura P et al.: Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Mol. Biochem. Parasitol. 165(2), 122-131 (2009).
-
(2009)
Mol. Biochem. Parasitol.
, vol.165
, Issue.2
, pp. 122-131
-
-
Nkrumah, L.J.1
Riegelhaupt, P.M.2
Moura, P.3
-
55
-
-
33746289507
-
Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum
-
Rohrbach P, Sanchez CP, Hayton K et al.: Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum. EMBO J. 25(13), 3000-3011 (2006).
-
(2006)
EMBO J.
, vol.25
, Issue.13
, pp. 3000-3011
-
-
Rohrbach, P.1
Sanchez, C.P.2
Hayton, K.3
-
56
-
-
54249123267
-
Polymorphisms within PfMDR1 alter the substrate specificity for anti-malarial drugs in
-
Sanchez CP, Rotmann A, Stein WD, Lanzer M: Polymorphisms within PfMDR1 alter the substrate specificity for anti-malarial drugs in Plasmodium falciparum. Mol. Microbiol. 70(4), 786-798 (2008).
-
(2008)
Plasmodium Falciparum. Mol. Microbiol.
, vol.70
, Issue.4
, pp. 786-798
-
-
Sanchez, C.P.1
Rotmann, A.2
Stein, W.D.3
Lanzer, M.4
-
57
-
-
77954761784
-
Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue
-
Pleeter P, Lekostaj JK, Roepe PD: Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue. Mol. Biochem. Parasitol. 173(2), 158-161 (2010).
-
(2010)
Mol. Biochem. Parasitol.
, vol.173
, Issue.2
, pp. 158-161
-
-
Pleeter, P.1
Lekostaj, J.K.2
Roepe, P.D.3
-
58
-
-
0034708162
-
Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
-
Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF: Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 403(6772), 906-909 (2000).
-
(2000)
Nature
, vol.403
, Issue.6772
, pp. 906-909
-
-
Reed, M.B.1
Saliba, K.J.2
Caruana, S.R.3
Kirk, K.4
Cowman, A.F.5
-
59
-
-
23744435838
-
Pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in
-
Sidhu ABS, Valderramos SG, Fidock DA: pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Mol. Microbiol. 57(4), 913-926 (2005).
-
(2005)
Plasmodium Falciparum. Mol. Microbiol.
, vol.57
, Issue.4
, pp. 913-926
-
-
Sidhu, A.B.S.1
Valderramos, S.G.2
Fidock, D.A.3
-
60
-
-
44449145387
-
Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite
-
Mehlotra RK, Mattera G, Bockarie MJ et al.: Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum. Antimicrob. Agents Chemoth. 52(6), 2212-2222 (2008).
-
(2008)
Plasmodium Falciparum. Antimicrob. Agents Chemoth.
, vol.52
, Issue.6
, pp. 2212-2222
-
-
Mehlotra, R.K.1
Mattera, G.2
Bockarie, M.J.3
-
61
-
-
73149118025
-
Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine
-
Sa JM, Twu O, Hayton K et al.: Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine. Proc. Natl Acad. Sci. USA 106(45), 18883-18889 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, Issue.45
, pp. 18883-18889
-
-
Sa, J.M.1
Twu, O.2
Hayton, K.3
-
62
-
-
0036467783
-
Levels of chloroquine resistance in Plasmodium falciparum are determined by loci other than pfcrt and pfmdr1
-
Chen NH, Russell B, Fowler E, Peters J, Cheng Q: Levels of chloroquine resistance in Plasmodium falciparum are determined by loci other than pfcrt and pfmdr1. J. Inf. Dis. 185(3), 405-406 (2002).
-
(2002)
J. Inf. Dis.
, vol.185
, Issue.3
, pp. 405-406
-
-
Chen, N.H.1
Russell, B.2
Fowler, E.3
Peters, J.4
Cheng, Q.5
-
63
-
-
49649107709
-
Genome-wide compensatory changes accompany drug-selected mutations in the Plasmodium falciparum crt gene
-
Jiang HY, Patel JJ, Yi M et al.: Genome-wide compensatory changes accompany drug-selected mutations in the Plasmodium falciparum crt gene. PloS One 3(6), E2484 (2008).
-
(2008)
PloS One
, vol.3
, Issue.6
-
-
Jiang, H.Y.1
Patel, J.J.2
Yi, M.3
-
64
-
-
4444359792
-
Redox and antioxidant systems of the malaria parasite Plasmodium falciparum
-
Müller S: Redox and antioxidant systems of the malaria parasite Plasmodium falciparum. Mol. Microbiol. 53(5), 1291-1305 (2004).
-
(2004)
Mol. Microbiol.
, vol.53
, Issue.5
, pp. 1291-1305
-
-
Müller, S.1
-
65
-
-
2142769136
-
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
-
Price RN, Uhlemann AC, Brockman A et al.: Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet 364(9432), 438-447 (2004).
-
(2004)
Lancet
, vol.364
, Issue.9432
, pp. 438-447
-
-
Price, R.N.1
Uhlemann, A.C.2
Brockman, A.3
-
66
-
-
33746302565
-
Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin
-
Sidhu ABS, Uhlemann AC, Valderramos SG, Valderramos JC, Krishna S, Fidock DA: Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. J. Inf. Dis. 194(4), 528-535 (2006).
-
(2006)
J. Inf. Dis.
, vol.194
, Issue.4
, pp. 528-535
-
-
Sidhu, A.B.S.1
Uhlemann, A.C.2
Valderramos, S.G.3
Valderramos, J.C.4
Krishna, S.5
Fidock, D.A.6
-
67
-
-
34249707784
-
PFMDR1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border
-
Alker AP, Lim P, Sem R et al.: PFMDR1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border. Am. J. Trop. Med. Hyg. 76(4), 641-647 (2007).
-
(2007)
Am. J. Trop. Med. Hyg.
, vol.76
, Issue.4
, pp. 641-647
-
-
Alker, A.P.1
Lim, P.2
Sem, R.3
-
68
-
-
33845663264
-
Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand
-
Uhlemann AC, McGready R, Ashley EA et al.: Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand. J. Inf. Dis. 195(1), 134-141 (2007).
-
(2007)
J. Inf. Dis.
, vol.195
, Issue.1
, pp. 134-141
-
-
Uhlemann, A.C.1
McGready, R.2
Ashley, E.A.3
-
69
-
-
0041355267
-
Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter
-
Waller KL, Muhle RA, Ursos LM et al.: Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter. J. Biol. Chem. 278(35), 33593-33601 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.35
, pp. 33593-33601
-
-
Waller, K.L.1
Muhle, R.A.2
Ursos, L.M.3
-
71
-
-
34047118015
-
Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance
-
Bennett TN, Patel J, Ferdig MT, Roepe PD: Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance. Mol. Biochem. Parasitol. 153(1), 48-58 (2007).
-
(2007)
Mol. Biochem. Parasitol.
, vol.153
, Issue.1
, pp. 48-58
-
-
Bennett, T.N.1
Patel, J.2
Ferdig, M.T.3
Roepe, P.D.4
-
72
-
-
77952683865
-
Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (pfnhe-1) gene with reduced in vitro susceptibility to quinine: Lack of confirmation in clinical isolates from Africa
-
Andriantsoanirina V, Menard D, Rabearimanana S et al.: Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from Africa. Am. J. Trop. Med. Hyg. 82(5), 782-787 (2010).
-
(2010)
Am. J. Trop. Med. Hyg.
, vol.82
, Issue.5
, pp. 782-787
-
-
Andriantsoanirina, V.1
Menard, D.2
Rabearimanana, S.3
-
73
-
-
77955392464
-
In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya
-
Okombo J, Kiara SM, Rono J et al.: In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya. Antimicrob. Agents Chemoth. 54(8), 3302-3307 (2010).
-
(2010)
Antimicrob. Agents Chemoth.
, vol.54
, Issue.8
, pp. 3302-3307
-
-
Okombo, J.1
Kiara, S.M.2
Rono, J.3
-
74
-
-
77957331643
-
In vitro Sensitivity of Plasmodium falciparum clinical isolates from the China-Myanmar border area to quinine and association with polymorphism in the Na+/H+ exchanger
-
Meng H, Zhang R, Yang H et al.: In vitro Sensitivity of Plasmodium falciparum clinical isolates from the China-Myanmar border area to quinine and association with polymorphism in the Na+/H+ exchanger. Antimicrob. Agents Chemother. 54(10), 4306-4313 (2010).
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, Issue.10
, pp. 4306-4313
-
-
Meng, H.1
Zhang, R.2
Yang, H.3
-
75
-
-
70349257342
-
Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane
-
Kavishe RA, van den Heuvel JMW, van de Vegte-Bolmer M, Luty AJF, Russel FGM, Koenderink JB: Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane. Malaria J. 8, 205 (2009).
-
(2009)
Malaria J.
, vol.8
, pp. 205
-
-
Kavishe, R.A.1
Van Den Heuvel, J.M.W.2
Van De Vegte-Bolmer, M.3
Luty, A.J.F.4
Russel, F.G.M.5
Koenderink, J.B.6
-
76
-
-
65549119262
-
Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione
-
Raj DK, Mu JB, Jiang HY et al.: Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione. J. Biol. Chem. 284(12), 7687-7696 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.12
, pp. 7687-7696
-
-
Raj, D.K.1
Mu, J.B.2
Jiang, H.Y.3
-
77
-
-
72849131450
-
Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa
-
Dahlstrom S, Ferreira PE, Veiga MI et al.: Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa. J. Inf. Dis. 200(9), 1456-1464 (2009).
-
(2009)
J. Inf. Dis.
, vol.200
, Issue.9
, pp. 1456-1464
-
-
Dahlstrom, S.1
Ferreira, P.E.2
Veiga, M.I.3
-
78
-
-
61849097741
-
In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
-
Sisowath C, Petersen I, Veiga MI et al.: In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa. J. Inf. Dis. 199(5), 750-757 (2009).
-
(2009)
J. Inf. Dis.
, vol.199
, Issue.5
, pp. 750-757
-
-
Sisowath, C.1
Petersen, I.2
Veiga, M.I.3
-
79
-
-
10744231302
-
Multiple transporters associated with malaria parasite responses to chloroquine and quinine
-
Mu JB, Ferdig MT, Feng XR et al.: Multiple transporters associated with malaria parasite responses to chloroquine and quinine. Mol. Microbiol. 49(4), 977-989 (2003).
-
(2003)
Mol. Microbiol.
, vol.49
, Issue.4
, pp. 977-989
-
-
Mu, J.B.1
Ferdig, M.T.2
Feng, X.R.3
-
80
-
-
77955921335
-
The ABCs of multidrug resistance in malaria
-
Koenderink JB, Kavishe RA, Rijpma SR, Russel FGM: The ABCs of multidrug resistance in malaria. Trends Parasitol. 26(9), 440-446 (2010).
-
(2010)
Trends Parasitol.
, vol.26
, Issue.9
, pp. 440-446
-
-
Koenderink, J.B.1
Kavishe, R.A.2
Rijpma, S.R.3
Russel, F.G.M.4
-
81
-
-
34548409606
-
Drug-resistant malaria - An insight
-
Hyde JE: Drug-resistant malaria - an insight. FEBS J. 274(18), 4688-4698 (2007).
-
(2007)
FEBS J.
, vol.274
, Issue.18
, pp. 4688-4698
-
-
Hyde, J.E.1
-
82
-
-
42349104331
-
Qinghaosu (Artemisinin): The price of success
-
White NJ: Qinghaosu (Artemisinin): the price of success. Science 320(5874), 330-334 (2008).
-
(2008)
Science
, vol.320
, Issue.5874
, pp. 330-334
-
-
White, N.J.1
-
83
-
-
76749140836
-
Role of medicines in malaria control and elimination
-
Warsame M, Olumese P, Mendis K: Role of medicines in malaria control and elimination. Drug Deveopl. Res. 71(1), 4-11 (2010).
-
(2010)
Drug Deveopl. Res.
, vol.71
, Issue.1
, pp. 4-11
-
-
Warsame, M.1
Olumese, P.2
Mendis, K.3
-
84
-
-
44849092217
-
Escalating Plasmodium falciparum antifolate drug resistance mutations in Macha, rural Zambia
-
Mkulama MAP, Chishimba S, Sikalima J, Rouse P, Thuma PE, Mharakurwa S: Escalating Plasmodium falciparum antifolate drug resistance mutations in Macha, rural Zambia. Malaria J. 7, 87 (2008).
-
(2008)
Malaria J.
, vol.7
, pp. 87
-
-
Mkulama, M.A.P.1
Chishimba, S.2
Sikalima, J.3
Rouse, P.4
Thuma, P.E.5
Mharakurwa, S.6
-
85
-
-
0036188538
-
Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs
-
Hyde JE: Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs. Microbes Infect. 4(2), 165-174 (2002).
-
(2002)
Microbes Infect.
, vol.4
, Issue.2
, pp. 165-174
-
-
Hyde, J.E.1
-
86
-
-
14144253009
-
Mechanisms of resistance of malaria parasites to antifolates
-
Gregson A, Plowe CV: Mechanisms of resistance of malaria parasites to antifolates. Pharmacol. Rev. 57(1), 117-145 (2005).
-
(2005)
Pharmacol. Rev.
, vol.57
, Issue.1
, pp. 117-145
-
-
Gregson, A.1
Plowe, C.V.2
-
87
-
-
65449188363
-
Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria
-
Pearce RJ, Pota H, Evehe MSB et al.: Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria. PloS Med. 6(4), E1000055 (2009).
-
(2009)
PloS Med.
, vol.6
, Issue.4
-
-
Pearce, R.J.1
Pota, H.2
Evehe, M.S.B.3
-
88
-
-
77955924411
-
Following the path of most resistance: Dhps K540E dispersal in African
-
Naidoo I, Roper C: Following the path of most resistance: dhps K540E dispersal in African Plasmodium falciparum. Trends Parasit. 26(9), 447-456 (2010).
-
(2010)
Plasmodium Falciparum. Trends Parasit.
, vol.26
, Issue.9
, pp. 447-456
-
-
Naidoo, I.1
Roper, C.2
-
89
-
-
0036467612
-
Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria
-
Kublin JG, Dzinjalamala FK, Kamwendo DD et al.: Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. J. Inf. Dis. 185(3), 380-388 (2002).
-
(2002)
J. Inf. Dis.
, vol.185
, Issue.3
, pp. 380-388
-
-
Kublin, J.G.1
Dzinjalamala, F.K.2
Kamwendo, D.D.3
-
90
-
-
77952702389
-
Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase mutations and the use of trimethoprim-sulfamethoxazole prophylaxis among persons infected with human immunodeficiency virus
-
Malamba S, Sandison T, Lule J et al.: Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase mutations and the use of trimethoprim-sulfamethoxazole prophylaxis among persons infected with human immunodeficiency virus. Am. J. Trop. Med. Hyg. 82(5), 766-771 (2010).
-
(2010)
Am. J. Trop. Med. Hyg.
, vol.82
, Issue.5
, pp. 766-771
-
-
Malamba, S.1
Sandison, T.2
Lule, J.3
-
91
-
-
77952728022
-
Five years of large-scale dhfr and dhps mutation surveillance following the phased implementation of artesunate plus sulfadoxine-pyrimethamine in Maputo province, southern Mozambique
-
Raman J, Little F, Roper C et al.: Five years of large-scale dhfr and dhps mutation surveillance following the phased implementation of artesunate plus sulfadoxine-pyrimethamine in Maputo province, southern Mozambique. Am. J. Trop. Med. Hyg. 82(5), 788-794 (2010).
-
(2010)
Am. J. Trop. Med. Hyg.
, vol.82
, Issue.5
, pp. 788-794
-
-
Raman, J.1
Little, F.2
Roper, C.3
-
92
-
-
14944343046
-
Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet?
-
Nzila A, Ochong E, Nduati E et al.: Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet? Trans. Roy. Soc. Trop. Med. Hyg. 99(5), 341-346 (2005).
-
(2005)
Trans. Roy. Soc. Trop. Med. Hyg.
, vol.99
, Issue.5
, pp. 341-346
-
-
Nzila, A.1
Ochong, E.2
Nduati, E.3
-
93
-
-
40249109761
-
Antifolate resistance in Africa and the 164-dollar question
-
Hyde JE: Antifolate resistance in Africa and the 164-dollar question. Trans. Roy. Soc. Trop. Med. Hyg. 102(4), 301-303 (2008).
-
(2008)
Trans. Roy. Soc. Trop. Med. Hyg.
, vol.102
, Issue.4
, pp. 301-303
-
-
Hyde, J.E.1
-
94
-
-
0035702490
-
Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: What next?
-
Sibley CH, Hyde JE, Sims PFG et al.: Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next? Trends Parasitol. 17(12), 582-588 (2001).
-
(2001)
Trends Parasitol.
, vol.17
, Issue.12
, pp. 582-588
-
-
Sibley, C.H.1
Hyde, J.E.2
Sims, P.F.G.3
-
95
-
-
33746125737
-
Antifolate resistance in Plasmodium falciparum: Multiple origins and identification of novel dhfr alleles
-
McCollum AM, Poe AC, Hamel M et al.: Antifolate resistance in Plasmodium falciparum: multiple origins and identification of novel dhfr alleles. J. Inf. Dis. 194(2), 189-197 (2006).
-
(2006)
J. Inf. Dis.
, vol.194
, Issue.2
, pp. 189-197
-
-
McCollum, A.M.1
Poe, A.C.2
Hamel, M.3
-
96
-
-
70349101632
-
In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: Emergence of parasites with Ile-64-Leu mutation
-
Kiara SM, Okombo J, Masseno V et al.: In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-64-Leu mutation. Antimicrob. Agents Chemoth. 53(9), 3793-3798 (2009).
-
(2009)
Antimicrob. Agents Chemoth.
, vol.53
, Issue.9
, pp. 3793-3798
-
-
Kiara, S.M.1
Okombo, J.2
Masseno, V.3
-
97
-
-
73849145317
-
Molecular correlates of high-level antifolate resistance in Rwandan children with Plasmodium falciparum malaria
-
Karema C, Imwong M, Fanello CI et al.: Molecular correlates of high-level antifolate resistance in Rwandan children with Plasmodium falciparum malaria. Antimicrob. Agents Chemoth. 54(1), 477-483 (2010).
-
(2010)
Antimicrob. Agents Chemoth.
, vol.54
, Issue.1
, pp. 477-483
-
-
Karema, C.1
Imwong, M.2
Fanello, C.I.3
-
98
-
-
55849108855
-
Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure
-
Ochong E, Bell DJ, Johnson DJ et al.: Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure. Antimicrob. Agents Chemoth. 52(11), 3883-3888 (2008).
-
(2008)
Antimicrob. Agents Chemoth.
, vol.52
, Issue.11
, pp. 3883-3888
-
-
Ochong, E.1
Bell, D.J.2
Johnson, D.J.3
-
99
-
-
0032145128
-
Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast
-
Cortese JF, Plowe CV: Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast. Mol. Biochem. Parasitol. 94(2), 205-214 (1998).
-
(1998)
Mol. Biochem. Parasitol.
, vol.94
, Issue.2
, pp. 205-214
-
-
Cortese, J.F.1
Plowe, C.V.2
-
100
-
-
67749098058
-
Stepwise acquisition of pyrimethamine resistance in the malaria parasite
-
Lozovsky ER, Chookajorn T, Brown KM et al.: Stepwise acquisition of pyrimethamine resistance in the malaria parasite. Proc. Natl Acad. Sci. USA 106(29), 12025-12030 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, Issue.29
, pp. 12025-12030
-
-
Lozovsky, E.R.1
Chookajorn, T.2
Brown, K.M.3
-
101
-
-
34249933661
-
Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitro
-
Sandefur CI, Wooden JM, Quaye IK, Sirawaraporn W, Sibley CH: Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitro. Mol. Biochem. Parasitol. 154(1), 1-5 (2007).
-
(2007)
Mol. Biochem. Parasitol.
, vol.154
, Issue.1
, pp. 1-5
-
-
Sandefur, C.I.1
Wooden, J.M.2
Quaye, I.K.3
Sirawaraporn, W.4
Sibley, C.H.5
-
102
-
-
33745726540
-
A systematic map of genetic variation in Plasmodium falciparum
-
Kidgell C, Volkman SK, Daily J et al.: A systematic map of genetic variation in Plasmodium falciparum. PloS Pathog. 2(6), 562-577 (2006).
-
(2006)
PloS Pathog.
, vol.2
, Issue.6
, pp. 562-577
-
-
Kidgell, C.1
Volkman, S.K.2
Daily, J.3
-
103
-
-
55449133690
-
Adaptive copy number evolution in malaria parasites
-
Nair S, Miller B, Barends M et al.: Adaptive copy number evolution in malaria parasites. PloS Genet. 4(10), E1000243 (2008).
-
(2008)
PloS Genet.
, vol.4
, Issue.10
-
-
Nair, S.1
Miller, B.2
Barends, M.3
-
104
-
-
0037316796
-
Malaria control and the evolution of drug resistance: An intriguing link
-
Hastings IM: Malaria control and the evolution of drug resistance: an intriguing link. Trends Parasitol. 19(2), 70-73 (2003).
-
(2003)
Trends Parasitol.
, vol.19
, Issue.2
, pp. 70-73
-
-
Hastings, I.M.1
-
105
-
-
0025252334
-
Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria
-
Peterson DS, Milhous WK, Wellems TE: Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proc. Natl Acad. Sci. USA 87(8), 3018-3022 (1990).
-
(1990)
Proc. Natl Acad. Sci. USA
, vol.87
, Issue.8
, pp. 3018-3022
-
-
Peterson, D.S.1
Milhous, W.K.2
Wellems, T.E.3
-
106
-
-
0025263958
-
Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance
-
Foote SJ, Galatis D, Cowman AF: Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance. Proc. Natl Acad. Sci. USA 87(8), 3014-3017 (1990).
-
(1990)
Proc. Natl Acad. Sci. USA
, vol.87
, Issue.8
, pp. 3014-3017
-
-
Foote, S.J.1
Galatis, D.2
Cowman, A.F.3
-
107
-
-
0028021624
-
Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase - Dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine
-
Brooks DR, Wang P, Read M, Watkins WM, Sims PFG, Hyde JE: Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase - dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur. J. Biochem. 224(2), 397-405 (1994).
-
(1994)
Eur. J. Biochem.
, vol.224
, Issue.2
, pp. 397-405
-
-
Brooks, D.R.1
Wang, P.2
Read, M.3
Watkins, W.M.4
Sims, P.F.G.5
Hyde, J.E.6
-
108
-
-
0028291789
-
Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum
-
Triglia T, Cowman AF: Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum. Proc. Natl Acad. Sci. USA 91(15), 7149-7153 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, Issue.15
, pp. 7149-7153
-
-
Triglia, T.1
Cowman, A.F.2
-
109
-
-
0031444278
-
Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in
-
Triglia T, Menting JGT, Wilson C, Cowman AF: Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum. Proc. Natl Acad. Sci. USA 94(25), 13944-13949 (1997).
-
(1997)
Plasmodium Falciparum. Proc. Natl Acad. Sci. USA
, vol.94
, Issue.25
, pp. 13944-13949
-
-
Triglia, T.1
Menting, J.G.T.2
Wilson, C.3
Cowman, A.F.4
-
110
-
-
0030801206
-
Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins
-
Wang P, Lee CS, Bayoumi R et al.: Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. Mol. Biochem. Parasitol. 89(2), 161-177 (1997).
-
(1997)
Mol. Biochem. Parasitol.
, vol.89
, Issue.2
, pp. 161-177
-
-
Wang, P.1
Lee, C.S.2
Bayoumi, R.3
-
111
-
-
67749129402
-
Novel pfdhps haplotypes among imported cases of Plasmodium falciparum malaria in the United Kingdom
-
Sutherland CJ, Fifer H, Pearce RJ et al.: Novel pfdhps haplotypes among imported cases of Plasmodium falciparum malaria in the United Kingdom. Antimicrob. Agents Chemoth. 53(8), 3405-3410 (2009).
-
(2009)
Antimicrob. Agents Chemoth.
, vol.53
, Issue.8
, pp. 3405-3410
-
-
Sutherland, C.J.1
Fifer, H.2
Pearce, R.J.3
-
112
-
-
65549160862
-
Emergence of an unusual sulfadoxine-pyrimethamine resistance pattern and a novel K540N mutation in dihydropteroate synthetase in Plasmodium falciparum isolates obtained from Car Nicobar island, India, after the 2004 tsunami
-
Lumb V, Das MK, Mittra P et al.: Emergence of an unusual sulfadoxine-pyrimethamine resistance pattern and a novel K540N mutation in dihydropteroate synthetase in Plasmodium falciparum isolates obtained from Car Nicobar island, India, after the 2004 tsunami. J. Inf. Dis. 199(7), 1064-1073 (2009).
-
(2009)
J. Inf. Dis.
, vol.199
, Issue.7
, pp. 1064-1073
-
-
Lumb, V.1
Das, M.K.2
Mittra, P.3
-
113
-
-
0242501573
-
Insights into antifolate resistance from malarial DHFR-TS structures
-
Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S et al.: Insights into antifolate resistance from malarial DHFR-TS structures. Nature Struct. Biol. 10(5), 357-365 (2003).
-
(2003)
Nature Struct. Biol.
, vol.10
, Issue.5
, pp. 357-365
-
-
Yuvaniyama, J.1
Chitnumsub, P.2
Kamchonwongpaisan, S.3
-
114
-
-
60749115341
-
Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria
-
Dasgupta T, Chitnumsub P, Kamchonwongpaisan S et al.: Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. ACS Chem. Biol. 4(1), 29-40 (2009).
-
(2009)
ACS Chem. Biol.
, vol.4
, Issue.1
, pp. 29-40
-
-
Dasgupta, T.1
Chitnumsub, P.2
Kamchonwongpaisan, S.3
-
115
-
-
34247489734
-
Folate metabolism as a source of molecular targets for antimalarials
-
Yuthavong Y, Kamchonwongpaisan S, Leartsakulpanich U, Chitnumsub P: Folate metabolism as a source of molecular targets for antimalarials. Future Microbiol. 1(1), 113-125 (2006).
-
(2006)
Future Microbiol.
, vol.1
, Issue.1
, pp. 113-125
-
-
Yuthavong, Y.1
Kamchonwongpaisan, S.2
Leartsakulpanich, U.3
Chitnumsub, P.4
-
116
-
-
44749084648
-
Revising antimalarial drug policy in Central America: Experience in Panama
-
Calzada JE, Samudio F, Bayard V, Obaldia N, de Mosca IB, Pascale JM: Revising antimalarial drug policy in Central America: experience in Panama. Trans. Roy. Soc. Trop. Med. Hyg. 102(7), 694-698 (2008).
-
(2008)
Trans. Roy. Soc. Trop. Med. Hyg.
, vol.102
, Issue.7
, pp. 694-698
-
-
Calzada, J.E.1
Samudio, F.2
Bayard, V.3
Obaldia, N.4
De Mosca, I.B.5
Pascale, J.M.6
-
117
-
-
71449098893
-
Shape- and chemical feature-based 3D-pharmacophore model generation and virtual screening: Identification of potential leads for P. falciparum DHFR enzyme inhibition
-
Adane L, Patel DS, Bharatam PV: Shape- and chemical feature-based 3D-pharmacophore model generation and virtual screening: identification of potential leads for P. falciparum DHFR enzyme inhibition. Chem. Biol. Drug Design 75(1), 115-126 (2010).
-
(2010)
Chem. Biol. Drug Design
, vol.75
, Issue.1
, pp. 115-126
-
-
Adane, L.1
Patel, D.S.2
Bharatam, P.V.3
-
118
-
-
33646542706
-
Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase- dihydropteroate synthase
-
de Beer TAP, Louw AI, Joubert F: Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase-dihydropteroate synthase. Bioorg. Med. Chem. 14(13), 4433-4443 (2006).
-
(2006)
Bioorg. Med. Chem.
, vol.14
, Issue.13
, pp. 4433-4443
-
-
De Beer, T.A.P.1
Louw, A.I.2
Joubert, F.3
-
119
-
-
18244404066
-
Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated Plasmodium falciparum malaria
-
Dzinjalamala FK, Macheso A, Kublin JG et al.: Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated Plasmodium falciparum malaria. Am. J. Trop. Med. Hyg. 72(3), 267-272 (2005).
-
(2005)
Am. J. Trop. Med. Hyg.
, vol.72
, Issue.3
, pp. 267-272
-
-
Dzinjalamala, F.K.1
MacHeso, A.2
Kublin, J.G.3
-
120
-
-
54949121788
-
Plasma folate level and high-dose folate supplementation predict sulfadoxine-pyrimethamine treatment failure in pregnant women in western Kenya who have uncomplicated malaria
-
van Eijk AM, Ouma PO, Williamson J et al.: Plasma folate level and high-dose folate supplementation predict sulfadoxine-pyrimethamine treatment failure in pregnant women in western Kenya who have uncomplicated malaria. J. Inf. Dis. 198(10), 1550-1553 (2008).
-
(2008)
J. Inf. Dis.
, vol.198
, Issue.10
, pp. 1550-1553
-
-
Van Eijk, A.M.1
Ouma, P.O.2
Williamson, J.3
-
121
-
-
0033022037
-
Utilization of exogenous folate in the human malaria parasite Plasmodium falciparum and its critical role in antifolate drug synergy
-
Wang P, Brobey RKB, Horii T, Sims PFG, Hyde JE: Utilization of exogenous folate in the human malaria parasite Plasmodium falciparum and its critical role in antifolate drug synergy. Mol. Microbiol. 32(6), 1254-1262 (1999).
-
(1999)
Mol. Microbiol.
, vol.32
, Issue.6
, pp. 1254-1262
-
-
Wang, P.1
Brobey, R.K.B.2
Horii, T.3
Sims, P.F.G.4
Hyde, J.E.5
-
122
-
-
34249934338
-
Characterisation of exogenous folate transport in Plasmodium falciparum
-
Wang P, Wang Q, Sims PFG, Hyde JE: Characterisation of exogenous folate transport in Plasmodium falciparum. Mol. Biochem. Parasitol. 154(1), 40-51 (2007).
-
(2007)
Mol. Biochem. Parasitol.
, vol.154
, Issue.1
, pp. 40-51
-
-
Wang, P.1
Wang, Q.2
Sims, P.F.G.3
Hyde, J.E.4
-
123
-
-
67049173048
-
Polymorphism in PfMRP1 (Plasmodium falciparum multidrug resistance protein 1) amino acid 1466 associated with resistance to sulfadoxine- pyrimethamine treatment
-
Dahlstrom S, Veiga MI, Martensson A, Bjorkman A, Gil JP: Polymorphism in PfMRP1 (Plasmodium falciparum multidrug resistance protein 1) amino acid 1466 associated with resistance to sulfadoxine-pyrimethamine treatment. Antimicrob. Agents Chemoth. 53(6), 2553-2556 (2009).
-
(2009)
Antimicrob. Agents Chemoth.
, vol.53
, Issue.6
, pp. 2553-2556
-
-
Dahlstrom, S.1
Veiga, M.I.2
Martensson, A.3
Bjorkman, A.4
Gil, J.P.5
-
124
-
-
70350616263
-
Discovery, mechanisms of action and combination therapy of artemisinin
-
Cui LW, Su XZ: Discovery, mechanisms of action and combination therapy of artemisinin. Expert Rev. Anti-Inf. Ther. 7(8), 999-1013 (2009).
-
(2009)
Expert Rev. Anti-Inf. Ther.
, vol.7
, Issue.8
, pp. 999-1013
-
-
Cui, L.W.1
Su, X.Z.2
-
125
-
-
70449732094
-
Artemisinin-based combination therapies: A vital tool in efforts to eliminate malaria
-
Eastman RT, Fidock DA: Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nature Rev. Microbiol. 7(12), 864-874 (2009).
-
(2009)
Nature Rev. Microbiol.
, vol.7
, Issue.12
, pp. 864-874
-
-
Eastman, R.T.1
Fidock, D.A.2
-
126
-
-
77952303346
-
Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: A randomised non-inferiority trial
-
Tshefu AK, Gaye O, Kayentao K et al.: Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether- lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial. Lancet 375(9724), 1457-1467 (2010).
-
(2010)
Lancet
, vol.375
, Issue.9724
, pp. 1457-1467
-
-
Tshefu, A.K.1
Gaye, O.2
Kayentao, K.3
-
127
-
-
77956129863
-
Amodiaquine resistance in Plasmodium falciparum malaria in Afghanistan is associated with the pfcrt SVMNT allele at codons 72 to 76
-
Beshir K, Sutherland CJ, Merinopoulos I et al.: Amodiaquine resistance in Plasmodium falciparum malaria in Afghanistan is associated with the pfcrt SVMNT allele at codons 72 to 76. Antimicrob. Agents Chemoth. 54(9), 3714-3716 (2010).
-
(2010)
Antimicrob. Agents Chemoth.
, vol.54
, Issue.9
, pp. 3714-3716
-
-
Beshir, K.1
Sutherland, C.J.2
Merinopoulos, I.3
-
128
-
-
40049110830
-
Artemisinin-based combination treatment of falciparum malaria
-
Nosten F, White NJ: Artemisinin-based combination treatment of falciparum malaria. Am. J. Trop. Med. Hyg. 77(6), 181-192 (2007).
-
(2007)
Am. J. Trop. Med. Hyg.
, vol.77
, Issue.6
, pp. 181-192
-
-
Nosten, F.1
White, N.J.2
-
129
-
-
77956155765
-
Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum
-
Briolant S, Henry M, Oeuvray C et al.: Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum. Antimicrob. Agents Chemoth. 54(9), 3537-3544 (2010).
-
(2010)
Antimicrob. Agents Chemoth.
, vol.54
, Issue.9
, pp. 3537-3544
-
-
Briolant, S.1
Henry, M.2
Oeuvray, C.3
-
130
-
-
77954781884
-
The pharmaceutical death-ride of dihydroartemisinin
-
Jansen FH: The pharmaceutical death-ride of dihydroartemisinin. Malaria J. 9, 212 (2010).
-
Malaria J.
, vol.9
, Issue.212
, pp. 2010
-
-
Jansen, F.H.1
-
131
-
-
77952696164
-
Drug discovery: Priming the antimalarial pipeline
-
Fidock DA: Drug discovery: priming the antimalarial pipeline. Nature 465(7296), 297-298 (2010).
-
(2010)
Nature
, vol.465
, Issue.7296
, pp. 297-298
-
-
Fidock, D.A.1
-
132
-
-
33751006146
-
Current perspectives on the mechanism of action of artemisinins
-
Golenser J, Waknine JH, Krugliak M, Hunt NH, Grau GE: Current perspectives on the mechanism of action of artemisinins. Int. J. Parasitol. 36(14), 1427-1441 (2006).
-
(2006)
Int. J. Parasitol.
, vol.36
, Issue.14
, pp. 1427-1441
-
-
Golenser, J.1
Waknine, J.H.2
Krugliak, M.3
Hunt, N.H.4
Grau, G.E.5
-
133
-
-
26444465676
-
The antimalarial drug artemisinin alkylates heme in infected mice
-
Robert A, Benoit-Vical F, Claparols C, Meunier B: The antimalarial drug artemisinin alkylates heme in infected mice. Proc. Natl Acad. Sci. USA 102(38), 13676-13680 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, Issue.38
, pp. 13676-13680
-
-
Robert, A.1
Benoit-Vical, F.2
Claparols, C.3
Meunier, B.4
-
134
-
-
0028109346
-
Reaction of antimalarial endoperoxides with specific parasite proteins
-
Asawamahasakda W, Ittarat I, Pu YM, Ziffer H, Meshnick SR: Reaction of antimalarial endoperoxides with specific parasite proteins. Antimicrob. Agents Chemoth. 38(8), 1854-1858 (1994).
-
(1994)
Antimicrob. Agents Chemoth.
, vol.38
, Issue.8
, pp. 1854-1858
-
-
Asawamahasakda, W.1
Ittarat, I.2
Pu, Y.M.3
Ziffer, H.4
Meshnick, S.R.5
-
135
-
-
0032568952
-
The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin
-
Bhisutthibhan J, Pan XQ, Hossler PA et al.: The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin. J. Biol. Chem. 273(26), 16192-16198 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, Issue.26
, pp. 16192-16198
-
-
Bhisutthibhan, J.1
Pan, X.Q.2
Hossler, P.A.3
-
136
-
-
77949661216
-
Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation
-
Wang J, Huang L, Li J et al.: Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. PLoS One 5(3), E9582 (2010).
-
(2010)
PLoS One
, vol.5
, Issue.3
-
-
Wang, J.1
Huang, L.2
Li, J.3
-
137
-
-
77949268296
-
DMSO triggers the generation of ROS leading to an increase in artemisinin and dihydroartemisinic acid in Artemisia annua shoot cultures
-
Mannan A, Liu CZ, Arsenault PR et al.: DMSO triggers the generation of ROS leading to an increase in artemisinin and dihydroartemisinic acid in Artemisia annua shoot cultures. Plant Cell Rep. 29(2), 143-152 (2010).
-
(2010)
Plant Cell Rep.
, vol.29
, Issue.2
, pp. 143-152
-
-
Mannan, A.1
Liu, C.Z.2
Arsenault, P.R.3
-
138
-
-
77950362015
-
The molecular mechanism of action of artemisinin - The debate continues
-
ONeill PM, Barton VE, Ward SA: The molecular mechanism of action of artemisinin - the debate continues. Molecules 15(3), 1705-1721 (2010).
-
(2010)
Molecules
, vol.15
, Issue.3
, pp. 1705-1721
-
-
Oneill, P.M.1
Barton, V.E.2
Ward, S.A.3
-
139
-
-
58249143778
-
Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent
-
Hartwig CL, Rosenthal AS, DAngelo J, Griffin CE, Posner GH, Cooper RA: Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent. Biochem. Pharmacol. 77(3), 322-336 (2009).
-
(2009)
Biochem. Pharmacol.
, vol.77
, Issue.3
, pp. 322-336
-
-
Hartwig, C.L.1
Rosenthal, A.S.2
Dangelo, J.3
Griffin, C.E.4
Posner, G.H.5
Cooper, R.A.6
-
140
-
-
0035955729
-
Cysteine 38 in p65/NF-kB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
-
Garcia-Pineres AJ, Castro V, Mora G et al.: Cysteine 38 in p65/NF-kB plays a crucial role in DNA binding inhibition by sesquiterpene lactones. J. Biol. Chem. 276(43), 39713-39720 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.43
, pp. 39713-39720
-
-
Garcia-Pineres, A.J.1
Castro, V.2
Mora, G.3
-
141
-
-
77955517585
-
What made sesquiterpene lactones reach cancer clinical trials?
-
Ghantous A, Gali-Muhtasib H, Vuorela H, Saliba NA, Darwiche N: What made sesquiterpene lactones reach cancer clinical trials? Drug Discov. Today 15(15-16), 668-678 (2010).
-
(2010)
Drug Discov. Today
, vol.15
, Issue.15-16
, pp. 668-678
-
-
Ghantous, A.1
Gali-Muhtasib, H.2
Vuorela, H.3
Saliba, N.A.4
Darwiche, N.5
-
143
-
-
22144461405
-
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins
-
Uhlemann AC, Cameron A, Eckstein-Ludwig U et al.: A single amino acid residue can determine the sensitivity of SERCAs to artemisinins. Nat. Struct. Mol. Biol. 12(7), 628-629 (2005).
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, Issue.7
, pp. 628-629
-
-
Uhlemann, A.C.1
Cameron, A.2
Eckstein-Ludwig, U.3
-
144
-
-
31944444061
-
Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10
-
Afonso A, Hunt P, Cheesman S et al.: Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10. Antimicrob. Agents Chemother. 50(2), 480-489 (2006).
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, Issue.2
, pp. 480-489
-
-
Afonso, A.1
Hunt, P.2
Cheesman, S.3
-
145
-
-
77956108989
-
Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance
-
Valderramos SG, Scanfeld D, Uhlemann AC, Fidock DA, Krishna S: Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance. Antimicrob. Agents Chemother. 54(9), 3842-3852 (2010).
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, Issue.9
, pp. 3842-3852
-
-
Valderramos, S.G.1
Scanfeld, D.2
Uhlemann, A.C.3
Fidock, D.A.4
Krishna, S.5
-
146
-
-
68049123592
-
Artemisinin resistance in Plasmodium falciparum malaria
-
Dondorp AM, Nosten F, Yi P et al.: Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 361(5), 455-467 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, Issue.5
, pp. 455-467
-
-
Dondorp, A.M.1
Nosten, F.2
Yi, P.3
-
147
-
-
57749099137
-
Evidence of artemisinin-resistant malaria in western Cambodia
-
Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM: Evidence of artemisinin-resistant malaria in western Cambodia. N. Engl. J. Med. 359(24), 2619-2620 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, Issue.24
, pp. 2619-2620
-
-
Noedl, H.1
Se, Y.2
Schaecher, K.3
Smith, B.L.4
Socheat, D.5
Fukuda, M.M.6
-
148
-
-
68149171175
-
Countries race to contain resistance to key antimalarial
-
Samarasekera U: Countries race to contain resistance to key antimalarial. Lancet 374(9686), 277-280 (2009).
-
(2009)
Lancet
, vol.374
, Issue.9686
, pp. 277-280
-
-
Samarasekera, U.1
-
149
-
-
77950943615
-
High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia
-
Anderson TJC, Nair S, Nkhoma S et al.: High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia. J. Inf. Dis. 201(9), 1326-1330 (2010).
-
(2010)
J. Inf. Dis.
, vol.201
, Issue.9
, pp. 1326-1330
-
-
Anderson, T.J.C.1
Nair, S.2
Nkhoma, S.3
-
152
-
-
77954324867
-
Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009
-
Thanh NV, Toan TQ, Cowman AF et al.: Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009. Malaria J. 9, 181 (2010).
-
Malaria J.
, vol.9
, Issue.181
, pp. 2010
-
-
Thanh, N.V.1
Toan, T.Q.2
Cowman, A.F.3
-
153
-
-
70350244603
-
Artemisinin resistance on the Thai-Cambodian border
-
Müller O, Sie A, Meissner P, Schirmer RH, Kouyate B: Artemisinin resistance on the Thai-Cambodian border. Lancet 374(9699), 1419 (2009).
-
(2009)
Lancet
, vol.374
, Issue.9699
, pp. 1419
-
-
Müller, O.1
Sie, A.2
Meissner, P.3
Schirmer, R.H.4
Kouyate, B.5
-
155
-
-
0035845430
-
Immune mimicry in malaria: Plasmodium falciparum secretes a functional histamine-releasing factor homolog in vitro and in vivo
-
MacDonald SM, Bhisutthibhan J, Shapiro TA et al.: Immune mimicry in malaria: Plasmodium falciparum secretes a functional histamine-releasing factor homolog in vitro and in vivo. Proc. Natl Acad. Sci. USA 98(19), 10829-10832 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, Issue.19
, pp. 10829-10832
-
-
MacDonald, S.M.1
Bhisutthibhan, J.2
Shapiro, T.A.3
-
156
-
-
0842341149
-
Plasmodium yoelii: Identification and partial characterization of an MDR1 gene in an artemisinin-resistant line
-
Ferrer-Rodriguez I, Perez-Rosado J, Gervais GW, Peters W, Robinson BL, Serrano AE: Plasmodium yoelii: identification and partial characterization of an MDR1 gene in an artemisinin-resistant line. J. Parasitol. 90(1), 152-160 (2004).
-
(2004)
J. Parasitol.
, vol.90
, Issue.1
, pp. 152-160
-
-
Ferrer-Rodriguez, I.1
Perez-Rosado, J.2
Gervais, G.W.3
Peters, W.4
Robinson, B.L.5
Serrano, A.E.6
-
157
-
-
0024807010
-
Antimalarial drugs currently in development
-
Gutteridge WE: Antimalarial drugs currently in development. J. Roy. Soc. Med. 82(Suppl. 17), 63-66 (1989).
-
(1989)
J. Roy. Soc. Med.
, vol.82
, Issue.SUPPL. 17
, pp. 63-66
-
-
Gutteridge, W.E.1
-
158
-
-
0031052025
-
Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite
-
Srivastava IK, Rottenberg H, Vaidya AB: Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J. Biol. Chem. 272(7), 3961-3966 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, Issue.7
, pp. 3961-3966
-
-
Srivastava, I.K.1
Rottenberg, H.2
Vaidya, A.B.3
-
159
-
-
20444504719
-
Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae
-
Kessl JJ, Ha KH, Merritt AK et al.: Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae. J. Biol. Chem. 280(17), 17142-17148 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.17
, pp. 17142-17148
-
-
Kessl, J.J.1
Ha, K.H.2
Merritt, A.K.3
-
160
-
-
22844435982
-
Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system
-
Mather MW, Darrouzet E, Valkova-Valchanova M et al.: Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system. J. Biol. Chem. 280(29), 27458-27465 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.29
, pp. 27458-27465
-
-
Mather, M.W.1
Darrouzet, E.2
Valkova-Valchanova, M.3
-
161
-
-
0016261205
-
Treatment of drug-resistant malaria in man
-
Clyde DF: Treatment of drug-resistant malaria in man. Bull. World Health Organ. 50(3-4), 243-249 (1974).
-
(1974)
Bull. World Health Organ.
, vol.50
, Issue.3-4
, pp. 243-249
-
-
Clyde, D.F.1
-
162
-
-
0033931237
-
Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site
-
Korsinczky M, Chen NH, Kotecka B, Saul A, Rieckmann K, Cheng Q: Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site. Antimicrob. Agents Chemoth. 44(8), 2100-2108 (2000).
-
(2000)
Antimicrob. Agents Chemoth.
, vol.44
, Issue.8
, pp. 2100-2108
-
-
Korsinczky, M.1
Chen, N.H.2
Kotecka, B.3
Saul, A.4
Rieckmann, K.5
Cheng, Q.6
-
163
-
-
33746742419
-
Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance
-
Berry A, Senescau A, Lelievre J et al.: Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance. Trans. Roy. Soc. Trop. Med. Hyg. 100(10), 986-988 (2006).
-
(2006)
Trans. Roy. Soc. Trop. Med. Hyg.
, vol.100
, Issue.10
, pp. 986-988
-
-
Berry, A.1
Senescau, A.2
Lelievre, J.3
-
164
-
-
0032781364
-
Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites
-
Srivastava IK, Morrisey JM, Darrouzet E, Daldal F, Vaidya AB: Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites. Mol. Microbiol. 33(4), 704-711 (1999).
-
(1999)
Mol. Microbiol.
, vol.33
, Issue.4
, pp. 704-711
-
-
Srivastava, I.K.1
Morrisey, J.M.2
Darrouzet, E.3
Daldal, F.4
Vaidya, A.B.5
-
165
-
-
0033063070
-
A mechanism for the synergistic antimalarial action of atovaquone and proguanil
-
Srivastava IK, Vaidya AB: A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob. Agents Chemoth. 43(6), 1334-1339 (1999).
-
(1999)
Antimicrob. Agents Chemoth.
, vol.43
, Issue.6
, pp. 1334-1339
-
-
Srivastava, I.K.1
Vaidya, A.B.2
-
166
-
-
33847398001
-
Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum
-
Painter HJ, Morrisey JM, Mather MW, Vaidya AB: Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature 446(7131), 88-91 (2007).
-
(2007)
Nature
, vol.446
, Issue.7131
, pp. 88-91
-
-
Painter, H.J.1
Morrisey, J.M.2
Mather, M.W.3
Vaidya, A.B.4
-
167
-
-
6944224039
-
Screening for mutations related to atovaquone/proguanil resistance in treatment failures and other imported isolates of Plasmodium falciparum in Europe
-
Wichmann O, Muehlberger N, Jelinek T et al.: Screening for mutations related to atovaquone/proguanil resistance in treatment failures and other imported isolates of Plasmodium falciparum in Europe. J. Inf. Dis. 190(9), 1541-1546 (2004).
-
(2004)
J. Inf. Dis.
, vol.190
, Issue.9
, pp. 1541-1546
-
-
Wichmann, O.1
Muehlberger, N.2
Jelinek, T.3
-
168
-
-
33750022628
-
Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa
-
Happi CT, Gbotosho GO, Folarin OA et al.: Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa. Malaria J. 5,82 (2006).
-
(2006)
Malaria J.
, vol.5
, pp. 82
-
-
Happi, C.T.1
Gbotosho, G.O.2
Folarin, O.A.3
-
169
-
-
77952450375
-
Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene
-
Afonso A, Neto Z, Castro H et al.: Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene. Malaria J. 9, 135 (2010).
-
Malaria J.
, vol.9
, Issue.135
, pp. 2010
-
-
Afonso, A.1
Neto, Z.2
Castro, H.3
-
170
-
-
60349110965
-
Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil
-
Sutherland CJ, Laundy M, Price N et al.: Mutations in the Plasmodium
-
(2008)
Malaria J.
, vol.7
, pp. 240
-
-
Sutherland, C.J.1
Laundy, M.2
Price, N.3
-
171
-
-
65649126746
-
A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria
-
Picot S, Olliaro P, de Monbrison F, Bienvenu AL, Price RN, Ringwald P: A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria. Malaria J. 8, 89 (2009)
-
(2009)
Malaria J.
, vol.8
, pp. 89
-
-
Picot, S.1
Olliaro, P.2
De Monbrison, F.3
Bienvenu, A.L.4
Price, R.N.5
Ringwald, P.6
-
172
-
-
77956487852
-
Anti-folate drug resistance in Africa: Meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations
-
Sridaran S, McClintock SK, Syphard LM, Herman KM, Barnwell JW, Udhayakumar V: Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations. Malaria J. 9, 247 (2010).
-
Malaria J.
, vol.9
, Issue.247
, pp. 2010
-
-
Sridaran, S.1
McClintock, S.K.2
Syphard, L.M.3
Herman, K.M.4
Barnwell, J.W.5
Udhayakumar, V.6
-
173
-
-
33646925083
-
Resisting resistance: Dealing with the irrepressible problem of malaria
-
Edwards G, Biagini GA: Resisting resistance: dealing with the irrepressible problem of malaria. Brit. J. Clin. Pharmacol. 61(6), 690-693 (2006).
-
(2006)
Brit. J. Clin. Pharmacol.
, vol.61
, Issue.6
, pp. 690-693
-
-
Edwards, G.1
Biagini, G.A.2
-
174
-
-
34250195398
-
A novel artemisinin-quinine hybrid with potent antimalarial activity
-
Walsh JJ, Coughlana D, Heneghan N, Gaynor C, Bell A: A novel artemisinin-quinine hybrid with potent antimalarial activity. Bioorg. Med. Chem. Lett. 17(13), 3599-3602 (2007).
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, Issue.13
, pp. 3599-3602
-
-
Walsh, J.J.1
Coughlana, D.2
Heneghan, N.3
Gaynor, C.4
Bell, A.5
-
176
-
-
0031037364
-
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase
-
Sirawaraporn W, Sathitkul T, Sirawaraporn R, Yuthavong Y, Santi DV: Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase. Proc. Natl Acad. Sci. USA 94(4), 1124-1129 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, Issue.4
, pp. 1124-1129
-
-
Sirawaraporn, W.1
Sathitkul, T.2
Sirawaraporn, R.3
Yuthavong, Y.4
Santi, D.V.5
-
177
-
-
0036791041
-
Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from
-
Hastings MD, Sibley CH: Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax. Proc. Natl Acad. Sci. USA 99(20), 13137-13141 (2002).
-
(2002)
Plasmodium Vivax. Proc. Natl Acad. Sci. USA
, vol.99
, Issue.20
, pp. 13137-13141
-
-
Hastings, M.D.1
Sibley, C.H.2
-
178
-
-
36749009600
-
Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination
-
Japrung D, Leartsakulpanich U, Chusacultanachai S, Yuthavong Y: Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination. Antimicrob. Agents Chemoth. 51(12), 4356-4360 (2007).
-
(2007)
Antimicrob. Agents Chemoth.
, vol.51
, Issue.12
, pp. 4356-4360
-
-
Japrung, D.1
Leartsakulpanich, U.2
Chusacultanachai, S.3
Yuthavong, Y.4
-
179
-
-
33750730913
-
Return of chloroquine antimalarial efficacy in Malawi
-
Laufer MK, Thesing PC, Eddington ND et al.: Return of chloroquine antimalarial efficacy in Malawi. N. Engl. J. Med. 355(19), 1959-1966 (2006).
-
(2006)
N. Engl. J. Med.
, vol.355
, Issue.19
, pp. 1959-1966
-
-
Laufer, M.K.1
Thesing, P.C.2
Eddington, N.D.3
-
180
-
-
67650685545
-
Chloroquine resistance before and after its withdrawal in Kenya
-
Mwai L, Ochong E, Abdirahman A et al.: Chloroquine resistance before and after its withdrawal in Kenya. Malaria J. 8, 106 (2009).
-
(2009)
Malaria J.
, vol.8
, pp. 106
-
-
Mwai, L.1
Ochong, E.2
Abdirahman, A.3
-
181
-
-
0642286204
-
Increasing prevalence of wildtypes in the dihydrofolate reductase gene of Plasmodium falciparum in an area with high levels of sulfadoxine/pyrimethamine resistance after introduction of treated bed nets
-
Alifrangis M, Lemnge MM, Ronn AM et al.: Increasing prevalence of wildtypes in the dihydrofolate reductase gene of Plasmodium falciparum in an area with high levels of sulfadoxine/pyrimethamine resistance after introduction of treated bed nets. Am. J. Trop. Med. Hyg. 69(3), 238-243 (2003).
-
(2003)
Am. J. Trop. Med. Hyg.
, vol.69
, Issue.3
, pp. 238-243
-
-
Alifrangis, M.1
Lemnge, M.M.2
Ronn, A.M.3
-
182
-
-
34250183082
-
Common origin and fixation of Plasmodium falciparum dhfr and dhps mutations associated with sulfadoxine-pyrimethamine resistance in a low-transmission area in South America
-
McCollum AM, Mueller K, Villegas L, Udhayakumar V, Escalante AA: Common origin and fixation of Plasmodium falciparum dhfr and dhps mutations associated with sulfadoxine-pyrimethamine resistance in a low-transmission area in South America. Antimicrob. Agents Chemoth. 51(6), 2085-2091 (2007).
-
(2007)
Antimicrob. Agents Chemoth.
, vol.51
, Issue.6
, pp. 2085-2091
-
-
McCollum, A.M.1
Mueller, K.2
Villegas, L.3
Udhayakumar, V.4
Escalante, A.A.5
-
183
-
-
14744276811
-
High prevalence of markers for sulfadoxine and pyrimethamine resistance in Plasmodium falciparum in the absence of drug pressure in the Ashanti Region of Ghana
-
Marks F, Evans J, Meyer CG et al.: High prevalence of markers for sulfadoxine and pyrimethamine resistance in Plasmodium falciparum in the absence of drug pressure in the Ashanti Region of Ghana. Antimicrob. Agents Chemoth. 49(3), 1101-1105 (2005).
-
(2005)
Antimicrob. Agents Chemoth.
, vol.49
, Issue.3
, pp. 1101-1105
-
-
Marks, F.1
Evans, J.2
Meyer, C.G.3
-
184
-
-
35748953756
-
Selection of antifolate-resistant Plasmodium falciparum by sulfadoxine-pyrimethamine treatment and infectivity to Anopheles mosquitoes
-
Mendez F, Herrera S, Murrain B et al.: Selection of antifolate-resistant Plasmodium falciparum by sulfadoxine-pyrimethamine treatment and infectivity to Anopheles mosquitoes. Am. J. Trop. Med. Hyg. 77(3), 438-443 (2007).
-
(2007)
Am. J. Trop. Med. Hyg.
, vol.77
, Issue.3
, pp. 438-443
-
-
Mendez, F.1
Herrera, S.2
Murrain, B.3
-
185
-
-
77952704258
-
Thousands of chemical starting points for antimalarial lead identification
-
Gamo FJ, Sanz LM, Vidal J et al.: Thousands of chemical starting points for antimalarial lead identification. Nature 465(7296), 305-310 (2010).
-
(2010)
Nature
, vol.465
, Issue.7296
, pp. 305-310
-
-
Gamo, F.J.1
Sanz, L.M.2
Vidal, J.3
-
186
-
-
77952718950
-
Chemical genetics of Plasmodium falciparum
-
Guiguemde WA, Shelat AA, Bouck D et al.: Chemical genetics of Plasmodium falciparum. Nature 465(7296), 311-315 (2010).
-
(2010)
Nature
, vol.465
, Issue.7296
, pp. 311-315
-
-
Guiguemde, W.A.1
Shelat, A.A.2
Bouck, D.3
-
187
-
-
0032815207
-
Apicomplexan plastids as drug targets
-
McFadden GI, Roos DS: Apicomplexan plastids as drug targets. Trends Microbiol. 7(8), 328-333 (1999).
-
(1999)
Trends Microbiol.
, vol.7
, Issue.8
, pp. 328-333
-
-
McFadden, G.I.1
Roos, D.S.2
-
188
-
-
43949134849
-
Apicoplast translation, transcription and genome replication: Targets for antimalarial antibiotics
-
Dahl EL, Rosenthal PJ: Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics. Trends Parasitol. 24(6), 279-284 (2008).
-
(2008)
Trends Parasitol.
, vol.24
, Issue.6
, pp. 279-284
-
-
Dahl, E.L.1
Rosenthal, P.J.2
-
189
-
-
77951957803
-
-
World Health Organization
-
World Health Organization: World Malaria Report (2009) http://whqlibdoc.who.int publications/ 2009/9789241563901-eng.pdf
-
(2009)
World Malaria Report
-
-
|