Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue

Molecular and Biochemical Parasitology

Volumn 173, Issue 2, 2010, Pages 158-161

  Pleeter, Perri ^a,b   Lekostaj, Jacqueline K ^a,b   Roepe, Paul D ^a,b  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ABC transporter; Mefloquine; Photolabelling; Quinine; Quinoline

Indexed keywords

CHLOROQUINE; MEFLOQUINE; MULTIDRUG RESISTANCE PROTEIN 1; QUININE; ANTIMALARIAL AGENT; MDR1 PROTEIN, PLASMODIUM FALCIPARUM; MULTIDRUG RESISTANCE PROTEIN; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; BINDING SITE; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; MULTIDRUG RESISTANCE;

ANTIMALARIALS; BINDING SITES; CHLOROQUINE; DRUG RESISTANCE, MULTIPLE; MEFLOQUINE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PLASMODIUM FALCIPARUM; PROTEIN BINDING; QUININE;

PLASMODIUM FALCIPARUM;

EID: 77954761784     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2010.05.012     Document Type: Article

References (22)

1. Cowman A.F., Karcz S., Galatis D., Culvenor J.G. A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole. J Cell Biol 1991, 113(5):1033-1042.
2. Wellems T.E., Panton L.J., Gluzman I.Y., et al. Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross. Nature 1990, 345:253-255.
3. Wilson C.M., Serrano A.E., Wasley A., Bogenschutz M.P., Shankar A.H., Wirth D.F. Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum. Science 1989, 244(4909):1184-1186.
4. Fidock D.A., Nomura T., Talley A.K., et al. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell 2000, 6(4):861-871.
5. Reed M.B., Saliba K.J., Caruana S.R., Kirk K., Cowman A.F. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 2000, 403(6772):906-909.
6. de Dios A.C., Tycko R., Ursos L.M.B., Roepe P.D. NMR studies of chloroquine-ferriprotoporphyrin IX complex. J Phys Chem A 2003, 107:5821-5825.
7. Pisciotta J.M., Sullivan D. Hemozoin: oil versus water. Parasitol Int 2008, 57(2):89-96.
8. Wellems T.E., Plowe C.V. Chloroquine-resistant malaria. J Infect Dis 2001, 184(6):770-776.
9. Sidhu A.B., Valderramos S.G., Fidock D.A. pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Mol Microbiol 2005, 57(4):913-926.
10. Amoah L.E., Lekostaj J.K., Roepe P.D. Heterologous expression and ATPase activity of wildtype vs mutant PfMDR1 protein. Biochemistry 2007, 46(20):6060-6073.
11. Lekostaj J.K., Amoah L.E., Roepe P.D. A single S1034C mutation confers altered drug sensitivity to PfMDR1 ATPase activity that is characteristic of the 7G8 isoform. Mol Biochem Parasitol 2008, 157(1):107-111.
12. Howard E.M., Roepe P.D. Purified human MDR 1 modulates membrane potential in reconstituted proteoliposomes. Biochemistry 2003, 42(12):3544-3555.
13. Lekostaj J., Natarajan J.K., Paguio M., Wolf C., Roepe P.D. Photoaffinity labeling of the Plasmodium falciparum chloroquine resistance transporter (PfCRT) with a novel perfluorophenylazido chloroquine. Biochemistry 2008, 47(39):10394-10406.
14. Paguio M., Cabrera M., Roepe P.D. Chloroquine transport in Plasmodium falciparum II: analysis of PfCRT mediated drug transport using proteoliposomes and a fluorescent chloroquine probe. Biochemistry 2009, 48:9482-9491.
15. Cabrera M., Paguio M.F., Xie C., Roepe P.D. Reduced digestive vacuolar accumulation of chloroquine is not linked to resistance to chloroquine toxicity. Biochemistry 2009, 48:11152-11154.
16. Glikoreijevic B., McAllister R., Urbach J., Roepe P.D. Spinning disk confocal microscopy of intraerythrocytic malarial parasites I: quantification of hemozoin development. Biochemistry 2006, 45:12400-12410.
17. Glikoreijevic B., Purdy K., Elliot D.A., Cooper R.A., Roepe P.D. Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy. Mol Biochem Parasitol 2008, 159:7-23.
18. Patel J, Thacker D, Tan JC, et al. Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross. Mol Microbiol; submitted for publication.
19. Casabianca L.B., An D., Natarajan J., et al. Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium. J Inorg Chem 2008, 47:6077-6081.
20. Bruggemann E.P., Currier S.J., Gottesman M.M., Pastan I. Characterization of the azidopine and vinblastine binding site of P-glycoprotein. J Biol Chem 1992, 267:21020-21026.
21. Greenberger L.M. Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12. J Biol Chem 1993, 268:11417-11425.
22. Aller S.G., Yu J., Ward A., et al. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science 2009, 5922:1718-1722.