Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

Molecular Cell

Volumn 6, Issue 4, 2000, Pages 861-871

  Fidock, David A ^a,b   Nomura, Takashi ^a   Talley, Angela K ^a   Cooper, Roland A ^a   Dzekunov, Sergey M ^c   Ferdig, Michael T ^a   Ursos, Lyann M B ^c   Bir Singh Sidhu, Amar ^b   Naudé, Bronwen ^a   Deitsch, Kirk W ^a   Su, Xin Zhuan ^a   Wootton, John C ^d   Roepe, Paul D ^c   Wellems, Thomas E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; DNA; MEMBRANE PROTEIN; VERAPAMIL;

ACIDIFICATION; ANTIBIOTIC RESISTANCE; ARTICLE; CELL VACUOLE; DIGESTIVE SYSTEM; DNA SEQUENCE; DRUG ANTAGONISM; DRUG BINDING; GENE MAPPING; GENETIC TRANSFECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; POINT MUTATION; PROTEIN LOCALIZATION;

PLASMODIUM FALCIPARUM;

EID: 0033636607     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(05)00077-8     Document Type: Article

References (42)

1. Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine
2. Access to hematin: The basis of chloroquine resistance
3. A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole
4. Stable transgene expression in Plasmodium falciparum
5. Aminoquinolines that circumvent resistance in Plasmodium falciparum in vitro
6. An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials
7. Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine
8. Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil
9. Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase
10. Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum
11. Plasmodium falciparum in owl monkeys: Drug resistance and chloroquine binding capacity
12. Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action
13. Hemoglobin degradation in the malaria parasite Plasmodium falciparum: An ordered process in a unique organelle
14. Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance?
15. Antimalarials increase vesicle pH in Plasmodium falciparum
16. Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria
17. Transfection of mu MDR 1 inhibits Na(+)-independent CI-/-HCO3 exchange in Chinese hamster ovary cells
18. Malaria disaster in Africa
19. Reversal of chloroquine resistance in Plasmodium falciparum by verapamil
20. Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect
21. Chloroquine uptake, altered partitioning and the basis of drug resistance: Evidence for a role of chloride-dependent ionic regulation
22. Spread of chloroquine resistance in Plasmodium falciparum
23. Antihistaminic drugs that reverse chloroquine resistance in Plasmodium falciparum
24. Immunocapture diagnostic assays for malaria using Plasmodium lactate dehydrogenase (pLDH)
25. Pgh1 modulates sensitivity and resistance to multiple anti-malarials in Plasmodium falciparum
26. 4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum
27. Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance
28. Pharmacogenomics of the cystic fibrosis transmembrane conductance regulator (CFTR) and the cystic fibrosis drug CPX using genome microarry analysis
29. Complex polymorphisms in a ~330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa
30. Plasmodium falciparum: Parasite typing by using a multicopy microsatellite marker, PfRRM
31. A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum
32. Mutant dihydrofolate reductase-thymidylate synthase genes in pyrimethamine-resistant Plasmodium falciparum with polymorphic chromosome duplications
33. Pyrimethamine resistant mutations in Plasmodium falciparum
34. Impact of chloroquine resistance on malaria mortality
35. The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive of resistant to chloroquine
36. Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross
37. Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7
38. Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization
39. Transfection of Plasmodium falciparum within human red blood cells
40. Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine
41. + exchanger determines chloroquine uptake in Plasmodium falciparum
42. Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine