Amodiaquine resistance in Plasmodium falciparum malaria in Afghanistan is associated with the pfcrt SVMNT allele at codons 72 to 76

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 9, 2010, Pages 3714-3716

  Beshir, Khalid ^a   Sutherland, Colin J ^a   Merinopoulos, Ioannis ^a   Durrani, Naeem ^b   Leslie, Toby ^a   Rowland, Mark ^a   Hallett, Rachel L ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b House 3 ^*  (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; DRUG METABOLITE;

AFGHANISTAN; ALLELE; ANTIBIOTIC RESISTANCE; ARTICLE; CODON; DRUG SELECTIVITY; DRUG TREATMENT FAILURE; GENE; GENE MUTATION; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; PLASMODIUM FALCIPARUM; PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER GENE; PLASMODIUM FALCIPARUM MULTIDRUG RESISTANCE GENE 1; PRIORITY JOURNAL; PROTOZOAL GENETICS;

AFGHANISTAN; ALLELES; AMODIAQUINE; ANIMALS; ANTIMALARIALS; CODON; DRUG RESISTANCE; HAPLOTYPES; MALARIA, FALCIPARUM; MEMBRANE TRANSPORT PROTEINS; POLYMORPHISM, GENETIC; PROTOZOAN PROTEINS;

EID: 77956129863     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00358-10     Document Type: Article

References (18)

1. Alifrangis, M., M. B. Dalgaard, J. P. Lusingu, L. S. Vestergaard, T. Staalsoe, A. T. Jensen, A. Enevold, A. M. Rønn, I. F. Khalil, D. C. Warhurst, M. M. Lemnge, T. G. Theander, and I. C. Bygbjerg. 2006. Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania. J. Infect. Dis. 193:1738-1741.
2. Cowman, A. F., D. Galatis, and J. K. Thompson. 1994. Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine. Proc. Natl. Acad. Sci. U. S. A. 91:1143-1147.
3. Dlamini, S. V., K. Beshir, and C. J. Sutherland. 2010. Markers of antimalarial drug resistance in Plasmodium falciparum isolates from Swaziland: identification of pfmdr1-86F in natural parasite isolates. Malar. J. 9:68.
4. Durrani, N., T. Leslie, S. Rahim, K. Graham, F. Ahmad, and M. Rowland. 2005. Efficacy of combination therapy with artesunate plus amodiaquine compared to monotherapy with chloroquine, amodiaquine or sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum in Afghanistan. Trop. Med. Int. Health 10:521-529.
5. Holmgren, G., J. Hamrin, J. Svärd, A. Mårtensson, J. P. Gil, and A. Björkman. 2007. Selection of pfmdr1 mutations after amodiaquine monotherapy and amodiaquine plus artemisinin combination therapy in East Africa. Infect. Genet. Evol. 7:562-569.
6. Humphreys, G. S., I. Merinopoulos, J. Ahmed, C. J. M. Whitty, T. K. Mutabingwa, C. J. Sutherland, and R. L. Hallett. 2007. Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria. Antimicrob. Agents Chemother. 51:991-997.
7. Khaliq, A. A., E. Fox, M. Sarwar, and G. T. Strickland. 1987. Amodiaquine fails to cure chloroquine resistant Plasmodium falciparum in the Punjab. Trans. R. Soc. Trop. Med. Hyg. 81:157-159.
8. Kremsner, P. G., G. M. Zotter, H. Feldmeier, W. Graninger, R. M. Rocha, and G. Wiedermann. 1988. A comparative trial of three regimens for treating uncomplicated falciparum malaria in Acre, Brazil. J. Infect. Dis. 158:1368-1371.
9. Mehlotra, R. K., G. Mattera, M. J. Bockarie, J. D. Maguire, J. K. Baird, Y. D. Sharma, M. Alifrangis, G. Dorsey, P. J. Rosenthal, D. J. Fryauff, J. W. Kazura, M. Stoneking, and P. A. Zimmerman. 2008. Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum. Antimicrob. Agents Chemother. 52:2212-2222.
10. Mutabingwa, T. K., D. Anthony, A. Heller, R. Hallett, J. Ahmed, C. Drakeley, B. M. Greenwood, and C. J. M. Whitty. 2005. Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial. Lancet 365:1474-1480.
11. Nsobya, S. L., C. Dokomajilar, M. Joloba, G. Dorsey, and P. J. Rosenthal. 2007. Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Antimicrob. Agents Chemother. 51:3023-3025.
12. Olliaro, P., and P. Mussano. 2003. Amodiaquine for treating malaria. Cochrane Database Syst. Rev. 2003:CD000016.
13. Picot, S., P. Olliaro, F. de Monbrison, A. L. Bienvenu, R. N. Price, and P. Ringwald. 2009. A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria. Malar. J. 8:89.
14. Sá, J. M., O. Twu, K. Hayton, S. Reyes, M. P. Fay, P. Ringwald, and T. E. Wellems. 2009. Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine. Proc. Natl. Acad. Sci. U. S. A. 106:18883-18889.
15. Sidhu, A. B. S., D. Verdier-Pinard, and D. A. Fidock. 2002. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science 298:210-213.
16. Sutherland, C. J., T. Haustein, N. Gadalla, M. Armstrong, J. F. Doherty, and P. L. Chiodini. 2007. Chloroquine-resistant Plasmodium falciparum infections among UK travellers returning with malaria after chloroquine prophylaxis. J. Antimicrob. Chemother. 59:1197-1199.
17. Warhurst, D. C. 2003. Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine. Malar. J. 2:31.
18. Zakeri, S., M. Afsharpad, T. Kazemzadeh, K. Mehdizadeh, A. Shabani, and N. D. Djadid. 2008. Association of pfcrt but not pfmdr1 alleles with chloroquine resistance in Iranian isolates of Plasmodium falciparum. Am. J. Trop. Med. Hyg. 78:633-640.