Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase-dihydropteroate synthase

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 13, 2006, Pages 4433-4443

  de Beer, Tjaart A P ^a   Louw, Abraham I ^a   Joubert, Fourie ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

DHPS; Dihydropteroate; Falciparum; Homology model; Malaria; PPPK; Sulfadoxine

Indexed keywords

4 AMINOBENZOIC ACID; DIHYDROFOLATE REDUCTASE; DIHYDROPTERIN PYROPHOSPHOKINASE DIHYDROPTEROATE SYNTHASE; DIHYDROPTEROATE SYNTHASE; FOLIC ACID ANTAGONIST; PHOSPHOTRANSFERASE; SULFADOXINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS ANTHRACIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG STRUCTURE; ENZYME STRUCTURE; ESCHERICHIA COLI; MOLECULAR DYNAMICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; POINT MUTATION; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIMALARIALS; BINDING SITES; DRUG RESISTANCE; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SULFADOXINE;

BACILLUS ANTHRACIS; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM; SACCHAROMYCES CEREVISIAE; STAPHYLOCOCCUS AUREUS;

EID: 33646542706     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.02.035     Document Type: Article

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