Insights into antifolate resistance from malarial DHFR-TS structures

Nature Structural Biology

Volumn 10, Issue 5, 2003, Pages 357-365

  Yuvaniyama, Jirundon ^a   Chitnumsub, Penchit ^b   Kamchonwongpaisan, Sumalee ^b   Vanichtanankul, Jarunee ^b   Sirawaraporn, Worachart ^a   Taylor, Paul ^c   Walkinshaw, Malcolm D ^c   Yuthavong, Yongyuth ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; ANTIMALARIAL AGENT; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; PROGUANIL; PYRIMETHAMINE; THYMIDYLATE SYNTHASE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DRUG BINDING; DRUG EFFICACY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE MUTATION; MALARIA; MALARIA FALCIPARUM; MULTIDRUG RESISTANCE; NONHUMAN; PARASITE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PLASMODIUM; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

PLASMODIUM FALCIPARUM;

EID: 0242501573     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb921     Document Type: Article

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