Utilization of exogenous folate in the human malaria parasite Plasmodium falciparum and its critical role in antifolate drug synergy

Molecular Microbiology

Volumn 32, Issue 6, 1999, Pages 1254-1262

  Wang, Ping ^a   Brobey, Reynolds K B ^b   Horii, Toshihiro ^b   Sims, Paul F G ^a   Hyde, John E ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; FANSIDAR; FOLIC ACID; FOLIC ACID ANTAGONIST; PYRIMETHAMINE; SULFADOXINE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENTIATION; DRUG RESISTANCE; DRUG TARGETING; FOLATE METABOLISM; NONHUMAN; PLASMODIUM; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

4-AMINOBENZOIC ACID; ANIMALS; ANTIMALARIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG RESISTANCE; DRUG SYNERGISM; FOLIC ACID; HUMANS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; SULFADOXINE; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0033022037     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1999.01437.x     Document Type: Article

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