Chloroquine transport via the malaria parasite's chloroquine resistance transporter

Science

Volumn 325, Issue 5948, 2009, Pages 1680-1682

  Martin, Rowena E ^a   Marchetti, Rosa V ^a   Cowan, Anna I ^b   Howitt, Susan M ^a   Bröer, Stefan ^a   Kirk, Kiaran ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b Australian National University   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; AMODIAQUINE; ARTEMISININ; CHLOROQUINE; PIPERAQUINE; QUININE; VERAPAMIL;

DIGESTIVE SYSTEM DISORDER; DISEASE RESISTANCE; DISEASE TRANSMISSION; GENE EXPRESSION; HEALTH CARE; MALARIA; MEMBRANE; MUTATION; PROTEIN;

ACIDITY; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TRANSPORT; FEMALE; IN VITRO STUDY; MALARIA; NONHUMAN; OOCYTE; PLASMODIUM FALCIPARUM; PREVALENCE; PRIORITY JOURNAL; PROTEIN BINDING; WILD TYPE; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CHLOROQUINE; DRUG RESISTANCE; HYDROGEN-ION CONCENTRATION; MEMBRANE POTENTIALS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; OLIGOPEPTIDES; OOCYTES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; VERAPAMIL; XENOPUS LAEVIS;

PLASMODIUM FALCIPARUM; XENOPUS LAEVIS;

EID: 70349524663     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1175667     Document Type: Article

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24. We thank J. Abbey, R. Summers, E. Baker, and R. Slatyer for technical assistance. This work was supported by the Australian National Health and Medical Research Council (NHMRC) (grant 471472) and the Australian Research Council (grant DP0559433). R.E.M. was supported by an NHMRC Australian Biomedical Fellowship (fellowship 520320).