Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 20, 2002, Pages 13137-13141

  Hastings, Michele D ^a   Sibley, Carol Hopkins ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; CHLOROQUINE; DIHYDROFOLATE REDUCTASE; ENZYME; ENZYME INHIBITOR; PYRIMETHAMINE;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DHFR GENE; DRUG EFFICACY; DRUG SENSITIVITY; ENZYME ANALYSIS; GENE; GENE MUTATION; MALARIA FALCIPARUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM VIVAX; POINT MUTATION; PRIORITY JOURNAL;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; INHIBITORY CONCENTRATION 50; MALARIA; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; PLASMODIUM VIVAX; POINT MUTATION; PYRIMETHAMINE; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES;

PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PROTOZOA;

EID: 0036791041     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.182295999     Document Type: Article

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